Ma ke ?ano maoli, aia ka mannose ma ke ?ano manuahi i kekahi mau hua?ai, e like me ka cranberries, nā ?āpala, nā ?alani, a me nā mea ?ē a?e. I loko o kēia mau kiko, pili ka mannose i ka synthesis o glycoproteins e ho?oponopono i ka hana o ka ?ōnaehana autoimmune. Ua hō?ike ?ia nā ha?awina ho?oma?ama?a mua e hiki i ka mannose ke mālama a pale i nā ma?i ma?i urinary tract, no laila ua ho?ohana ?ia kekahi mau huahana olakino ?ē a?e me ka mannose ka mea nui e mālama i ke olakino ?ōnaehana urinary.

Ua ?ike lō?ihi ?ia he koi ki?eki?e a?e o nā ma?i koko no ka glucose ma mua o nā kiko ma?amau. Hiki ke lawe ?ia ka nui o ka glucose a hiki i ka 10 manawa e like me nā cell ma?amau a hilina?i hou i ka glycolysis no ka ikehu e ho?omau i ko lākou ulu wikiwiki. Eia na?e, ?o ka "sugar like life" tumor, ma ke alo o ka mannose, akā he ?ano kūlana ?ē a?e. I ka makahiki 2018, ua pa?i ka puke mo?olelo Nature i kahi noi?i blockbuster mai Cancer Research UK e hiki i ka mannose ke pale i nā ?ōpū. Ua ?ike ka po?e noi?i ma hope o ke komo ?ana o ka mannose i loko o nā pūnaewele ma ke ?ano o ka mannose 6-phosphate, e ālai ana i ke kumu ikehu o ke koko ma o ka ho?opili ?ana i ka metabolism glucose, no laila ke kāohi nei i ka ulu ?ana o nā cell tumor. I mea e hō?oia?i?o ai i kēia hopena, ua ho?okō ka po?e noi?i i ka ?imi hou a?e i ke kumu ho?ohālike o ka ?iole, ua ho?ohui lākou i ka mannose i ka wai inu o kēia mau ?iole "cancer", a loiloi i ka hopena o ka mannose waha i ka mālama ?ana i nā ?ano ma?i ma?i like ?ole e like me ka ma?i ma?i pancreatic a me ka ma?i kanesa o ka ?iole. Ua hō?ike ?ia nā hopena ?o ka ho?ohana waha ?ana i ka mannose ma ka inu ?ana i ka wai i ho?opane?e maika?i i ka ulu ?ana o ka ?iole. Ma hope o ka hō?oia ?ana i ka hopena therapeutic o ka mannose i loko o kahi kumu ho?ohālike ?iole, ua no?ono?o ka po?e noi?i i ka lawelawe ?ana i ka mannose i nā ?iole ma kahi o ka chemotherapy no ka mālama adjuvant, a kāhāhā lākou i ka ?ike ?ana ua ho?onui ka mannose i ka hopena therapeutic o ka chemotherapy, ?a?ole wale i ka emi ?ana o ka nui o ka tumora i nā ?iole, akā e ho?olō?ihi i ke ola o nā ?iole "cancerous". I kēia makahiki, ua ?ike ka hui noi?i ?o Fudan University i kahi ala hou o ka mannose anti-cancer - e ho?oponopono ana i ka molekele PD-L1. He aha ke ?ano hō?oia ?ana o ka ma?i tumor? Ua ?ike mākou i ka wā e komo ai nā kino ?ē e like me nā bacteria waho a me nā ma?i virus a i ?ole nā ????selula i loko o ke kino e make a lilo i ka ma?i kanesa, e ho?āla ?ia ka hana immune o ke kino kanaka, a e pā?ani ka ?ōnaehana pale ma hope o ka ho?āla ?ia ?ana e wehe i kēia mau "molekele malihini". I ka manawa like, i mea e pale aku ai i ka ho?oulu ?ana o ka ?ōnaehana pale a me ka "pepehi ?ole ?ole" o nā ?i?o ma?amau ma?amau i loko o ke kino, aia kahi pū?ulu o nā "mole mole kino" i loko o ko mākou kino. ?O ka PD-L1 kahi mole ko?iko?i i loko o ko mākou kino, hiki iā ia ke ho?opa?a i ka mole PD-1 ma ka ?ili o nā cell immune a ho?ouna i kahi hō?ailona "brake" i nā cell immune e pale i ka pepehi ?ana o nā cell ma?amau e nā cell immune (Figure 2). Eia nō na?e, ho?ohana ?ia kēia ?ōnaehana pale i loko o ko mākou kino e nā pūnaewele ma?alea ma?alahi, a ?o nā pūnaewele T i ka microenvironment tumor ke kuleana no ka pepehi ?ana i nā ?ōpū, a e ho?oku?u nā pūnaewele "brake" i nā pūnae T ma o ka hō?ike ki?eki?e o nā molela PD-L1, e kāohi ana i ka hana o nā pūnaewele T, i mea e pale ai i ka pepehi ?ana i ka ?ōnaehana pale.

?O ka mole PD-L1 he pūmua waiwai i ka ho?ololi glycosylation. Ua ?ike ka hui noi?i o ke Kulanui ?o Fudan e hiki i ka mannose ke ho?opau i ke kūpa?a o ka protein PD-L1 ma o ka ho?oponopono ?ana i ka glycosylation o nā molekala PD-L1, no laila e ho?olaha ana i ka ho?oha?aha?a ?ana o nā molekala PD-L1. No laila, i ka wā i ho?oha?aha?a ?ia ai ka molekala PD-L1 i hō?ike ?ia i loko o nā pūnaewele tumo e ka mannose, ?a?ole hiki i nā pūnaewele tumo ke ho?oikaika i nā cell T e "brake"? Ua hō?oia ka po?e noi?i i ke kuhiakau: ?oi aku ka nui o ka pepehi ?ia ?ana o nā cell tumor i mālama ?ia me ka mannose e nā cell T; I ke kumu ho?ohālike o ka ?iole, hiki i ka mannose waha ke ho?oikaika i ka ho?ouka ?ana a me ka pepehi ?ana i nā pūnae T i ka ?ōpū a ke?ake?a i ka ulu ?ana o ka ?ōpū, a ?o ka hui pū ?ana o ka mannose a me ka immune checkpoint antibody lā?au e ho?oikaika hou i ka ho?ouka ?ana a me ka pepehi ?ana i nā pūnae T i ka ?ōpū, a ho?onui loa i ke ola o nā ?iole "cancer".

E like me kā mākou i ?ōlelo ai ma mua, loa?a maoli ka mannose i kekahi mau hua?ai, ?oi aku ka nui o nā cranberries me ka manose ki?eki?e loa (Figure 3). Nui paha ka po?e e no?ono?o nei, hiki anei i ka ?ai ?ana i nā cranberry ke pale a mālama paha i ka ma?i kanesa? ?O ka?oia?i?o,?o ka nui o ka mannose i hā?awi?ia i nā?iole "cancer" i loko o nā ha?awina?elua i luna nei he ki?eki?e e like me 20%,?o ia ho?i,?o kēlā me kēia 100ml o ka wai inu he 20g o ka mannose, he ki?eki?e loa a me ka nui. No laila, ?ai mākou i nā cranberries a me nā hua?ai ?ē a?e e ho?onui i ka ?ai ?ana o ka mannose, i kekahi ?ano, hiki ke ho?oikaika i ka pale ?ana, kūpono i ke olakino, akā makemake e ho?okō i ka hopena o nā cranberries anti-cancer wale nō ?a?ole lawa.