1.1 Mai ka ho?oponopono ?ana o ka membrane cell i ka ho?oponopono Cerebrovascular

No ka mea i ho?okumu mua ?ia ?o Citicoline e Takeda Pharmaceutical o Iapana i ka makahiki 1956, hiki ke mana?o ?ia kāna mo?olelo noi?i he mo?olelo o ka ho?onui ?ana i ka cognitive:

• 1980s:Ho?ohana wale ?ia ma ke ?ano he mea ho?oponopono cell membrane ma hope o ka hahau ?ana

• 2010s:Ua ?ike ?ia hiki ke ho?onui i ke koko cerebral (hō?ike ?o PET-CT i ka pi?i ?ana o 23% o ke kahe koko lobe temporal)

• I ka makahiki 2024,ka NIH o ?Amelika Hui Pū ?Ia i helu ?ia ma ke ?ano he mea ho?oponopono ko?iko?i no ka "neurovascular coupling"

1.2 Ka ulu ?ana o ka mākeke honua

Wahi a ka ?ikepili o Evaluate Pharma:

Ua hō?ea ke kū?ai aku o ka honua i 4.7 biliona kālā US ma 2024 (CAGR 12.3%)

Ua ho?onui ?ia ka ho?ohana ?ana i ka lā?au lapa?au i nā haukapila ma Kina e 400% i ?ekolu mau makahiki

Ua ho?onui ?ia nā hō?ailona i:

Vascular dementia (MMSE helu i ho?omaika?i ?ia e 2.1 mau helu)

?O ka ?eha lolo ma?i (GOS prognostic scale i ho?onui ?ia e nā māka 1.5)

Mokuna ?Elua: ?O ka Ha?i ?ana o ka pahu ?ele?ele o ka Mechanism of Action

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2.1 Nā ala hana ?ekolu

Ka pae hō?ike hopena hopena: Ho?oponopono ka ho?oponopono ?ana o Phosphatidylcholine i ka pono o ka membrane neuronal Papa I: Ho?onui ka Acetylcholine precursors i ka ho?ouna ?ana o ka neurotransmitter Papa IIA: Ho?omaika?i ka ho?oponopono o ka nitric oxide synthase i ka microvascular dilation (ho?onui ?ia e 18%) Papa IIB

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2.2 Ka manawa puka aniani gula

Ua hō?ike ?ia kahi ha?awina 2024 e ka Hale Hō?ike?ike Hui Pū ?Ia o Sun Yat-sen University:

Hiki ke ho'ōla i ka wahi o ka penumbra ischemic i loko o 6 mau hola ma hope o ka infarction cerebral a hiki i 7.2cm.3

Eia na?e, ?a?ohe ?oko?a ko?iko?i i ka helu ?ana i ka wā i ?oi aku ai ka lawelawe ?ana ma mua o 72 mau hola (p=0.34).

Mokuna ?Ekolu: ?O ka Vortex of Controversy

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3.1 Kālua e pili ana i ka Pono

UK NICE Guidelines: Mana?o ?ia ?a?ole lawa nā hō?ike e kū nei no ke kāko?o ?ana i ka ho?opi?i ?inikua olakino (uku-effectiveness ratio ￡45,000/QALY)

Lancet Neurology **2025 Meta-analysis: ?A?ohe ?oko?a ko?iko?i mai kahi placebo i loko o ka pū?ulu hō?ino na?au ha?aha?a (p=0.21)

3.2 Chaos i ka Ho?olaha Kalepa

?O ka ho?olaha ?ana o ka National Medical Products Administration 2024:

Ua ho?onui nā ?oihana he ?umikūmālua i nā hō?ailona (e ho?olaha ana i ka "adjuvant therapy" ma ke ?ano he "reversing dementia")

Hō?ike nā ho?ā?o ma kahi kahua e-commerce ?o ka ?ike maoli o 32% o ka ho?omākaukau waha ma lalo o 70% o ka nui i hō?ailona ?ia.

Mokuna ?Ehā: Nā Palena o nā Kūlana ?enehana

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4.1 Pūnaehana lawe lā?au hou

?O nā liposomes i ho?ololi ?ia e ka lolo-koko e komo ana i ka peptide (Patent of Peking University Team, CN202410123456.7)

?O nā microneedles i ho?oku?u ?ia i pane ?ia (hō?ike ?ia nā ho?okolohua holoholona ma Seoul National University ma South Korea i ?ekolu pi?i ?ana o ka bioavailability)

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4.2 Ka wana?ao o ka lā?au ho?okahi

Ua ?ike ?ia ka noi?i hui a Bgi:

?O ka hopena o ka lā?au lapa?au o ka CDP-cholinesterase gene polymorphic population (helu kālā no 31% o ka heluna kanaka ?Asia) ua ho?onui ?ia e 47%

Mokuna ?Elima ?Ikepili o ka honua maoli o nā ma?i

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5.1 Nā hihia i loa?a

?O kahi mo?olelo mai kahi haukapila ki?eki?e ma Hangzhou: Ma hope o ka mālama ?ana i ka hui ?ana, ua ho?iho?i ?ia ka hiki ke kahe o ke koko cerebral o kahi mea ma?i 62 makahiki me ka infarction cerebral mai 32% a 89%

5.2 ?ōlelo pono?ī o ka ?ao?ao kūpono ?ole

"?O ka lawe ?ana iā ia no ka hapalua o ka makahiki ho?omau, ?o ka lilo o ka mahina o 300 yuan i lawe mai i ka ?eha o ka ?ōpū" - kahi mo?olelo ninaninau a Ms. Li, he mea ma?i mai Beijing