?Oi aku ma mua o 500 miliona mau kānaka ma ka honua holo?oko?a i loa?a i ka ma?i diabetes, 90% o lākou he ma?i diabetes type 2. Pono ka po?e ma?i e ho?omalu i ka loli ?ana o ke kō koko no ke ola, a ua helu ?ia nā kōpa?a ku?una (e like me ka sucrose a me ka fructose) ma ke ?ano he mea hō?ai?ē i ka mea?ai no ka mea e ho?oulu pololei i ke kō koko. Eia nō na?e, pa?akikī ke ho?opau ?ana i ke koi physiological o ke kanaka no ka ?ono ?ono, a ua puka mai nā huahana pani kō. ?O Sucralose, ma ke ?ano he mea ?ono o ka hanauna ?ehā, ua ho?okipa nui ?ia no kāna mau waiwai "zero calories a me ka momona ki?eki?e" ?13.

2. Nā hi?ohi?ona metabolic a me ka palekana o ka sucralose
1. Pono ka metabolic
Ho?ololi ?ia ka molecular structure o ka sucralose e ka chlorination, ?a?ole ia e decomposed e nā enzyme digestive kanaka. Ma kahi o 85% o ka sucralose e ho?oku?u pololei ?ia ma o ka ?ōpū ma hope o ka ?ai ?ana, a ?o ke koena 15% e ho?ololi ?ia i loko o nā pūhui non-toxic e ke ake a ho?oku?u ?ia i loko o ka mimi. Ua hō?oia ?ia nā ha?awina ho?oma?ama?a he 0 kāna glycemic index, a ?a?ohe pilina pololei me ka huna ?ana o ka insulin ?12. No ka la?ana, ?a?ole i hō?ike ?ia kahi ho?okolohua ho?okele 2024 e ka International Diabetes Federation (IDF) i nā loli ko?iko?i i ka ho?okē ?ai koko glucose a me nā pae A1C i 50 mau mea ma?i me ka ma?i ma?i type 2 i inu i nā mea inu sucralose no 30 mau lā ?5.

2. ?Ikepili dialectical o nā ho?opa?apa?a palekana
?Oiai ke kāko?o nei ka noi?i nui i kona palekana, aia nō nā hopohopo e pili ana i nā pilikia e hiki mai ana:

? gut microbiota impact ? : Ua hō?ike ?ia kahi ha?awina 2024 i pa?i ?ia ma Nature Microbiology i ka ?ai ?ana i kēlā me kēia lā ma mua o 15g o ka sucralose i kāohi i ka hana o nā probiotics e like me ka bifidobacterium, ka hopena i ka emi ?ana o 20%-30% o ka ?oko?a microbiota gut ?37;
Nā pilina lā?au: Ke hui pū ?ia me ka warfarin anticoagulant, hiki i ka sucralose ke hō?emi i ka bioavailability o ka lā?au ma 12%-15%. Pono e lawe ?ia he 27 mau hola ma ke ka?awale;
?
ka hana ?ana i nā pilikia o ka huahana ? : ?o ka kuke ?ana i ka wela ki?eki?e (> 150 ℃) hiki ke ho?ohua i ka nui o ka chloropropanol (?O ke kolu, ?o ka ho?olālā ?epekema o ke pani kō
1. Ho?ololi ?ia ka mana o ka dosage i ke ?ano
Mana?o ka World Health Organization (WHO) i ka po?e me ka ma?i diabetes e ?ai ?ole ma mua o 9mg/kg o ka sucralose i kēlā me kēia lā (e pili ana i 540mg no kahi pākeke 60kg). Pono e ho?oka?awale ?ia nā hi?ohi?ona ma nā noi kūpono:

? inu ?ala ? : 300ml mea?ai mea?ai aia ma kahi o 30mg sucralose, ?o ia wale nō ka 5.5% o ka palena palekana ?16;
? mea kālua ? : E koho i ka pāpa?i i hana ?ia ma ke ka?ina hana ha?aha?a ha?aha?a (2. Ho?oponopono mea?ai ho?ohui
?A?ole nā ??mea pani kō i pani no ka ho?omalu kōpa?a holo?oko?a:

? ka mea?ai kaulike ? : Ho?ohui i nā kī?aha holo?oko?a (GI ma lalo o 55) a me ka fiber mea?ai (25-30g i kēlā me kēia lā) e ho?opane?e i ka komo ?ana o ka glucose ?46;
? ka nānā ?ana i ka glucose koko ? : Ua ?ike ?ia ke koko glucose 2 mau hola ma hope o ka ?ai ?ana i nā mea?ai pani kō, a ua ho?okumu ?ia kahi waihona pane ho?okahi 58.
4. Nā kūlana hana a me ka ho?ona?auao mea kū?ai
1. Ho?ohālikelike o ka hō?ailona mea?ai
?O ka mana hou o ka China's General Rules for Nutrition Labeling of Prepackaged Foods ma 2025, pono e hō?ailona ?ia nā mea?ai i loa?a i ka sucralose me ka ?ōlelo a?o "Pono ka po?e ma?i ma?i ma?i e mālama i ka nui o ka lawe ?ana i ka carbohydrate" a hō?ike i ka mea ho?ohui (mg/100g) 24.

2. Makeke chaos pane
I ka makahiki 2024, ua ?ike ka General Administration of Market Supervision he 18.7% o ka mālama ?ana i ka "sugar-free" i ho?ohui maoli i ka glucose, e like me ka sucralose. Pono nā mea kū?ai aku e koho i nā huahana me ka hō?oia SC a me nā hō?ike ho?ā?o piha ?78.

5. Ke Kuhikuhi Ho?omohala e hiki mai ana
1. ?enehana hou
I ka makahiki 2025, ua ho?okumu ?o Jinhe Industrial i ke ka?ina "directed chlorination" e hō?emi i ke koena o ka sucralose chloropropanol i 0.01ppm, a ho?olō?ihi i ka manawa ho?oku?u o ka ?ōpū ma o ka ?enehana microcapsule e hō?emi i ka haunaele bacteria ?18.

2. Ka noi?i lapa?au e pili ana i nā hō?ike
Ua ho?okumu ka International Diabetes Association i kahi papahana "sugar replacement and metabolic syndrome" no 5 mau makahiki e nānā i ka palekana lō?ihi o ka sucralose i 100,000 po?e me ka ma?i diabetes.