He loiloi hou kēia, i pa?i ?ia ma ka puke mo?olelo hanohano Nutrients i Pepeluali 2024, na Ligia J. Dominguez a me nā mea ?ē a?e mai ke Kulanui o Palermo a me ke Kulanui o Enna ma Italia. Ua nānā pono lākou i ka pilina ma waena o ka magnesium a me nā hō?ailona o ka ?elemakule i loko o ke kino o ke kanaka, a ?ike ?ia hiki i kēia mineral ma?amau ke ho?olohi i ka helu o ka ?elemakule, he mea kupanaha loa!

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Nā ?ōlelo a?oa?o nui:

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1. ?O Magnesium ka hā o ka nui o ka mineral element i loko o ke kino o ke kanaka a pili pono i ka hana o nā enzymes ?oi aku ma mua o 600, e pili ana i nā ?ano hana physiological.

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2. He mea ma?amau ka hemahema o ka magnesium i ka po?e?elemakule, e pili ana i nā kumu he nui e like me nā genes, ka nohona a me ka nohona. ?A?ole lawa ka magnesium i loko o ke kino hiki ke ho?olalelale i ke ka?ina hana ?elemakule.

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3. Ua ?ike nā ha?awina e hiki i ka magnesium ke ho?opili i nā hi?ohi?ona nui 12 o ka ?elemakule, me ka genomic instability, ka pōkole telomere, a me nā loli epigenetic. Mana?o ?ia ka ho?ohui ?ana o ka Magnesium e lohi i ka ?elemakule a ho?omaika?i i nā mana?olana olakino.

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Eia kahi hō?ulu?ulu kiko?ī o ka ?atikala kumu:

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?O ka nele o ka Magnesium ka wikiwiki o 12 mau hi?ohi?ona kahiko

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Genomic instability: Ho?opa?a ka Magnesium i ka DNA double helix structure a komo i nā ?ano hana ho?oponopono DNA. Hiki i ka hemahema o ka Magnesium ke alaka?i i ka hō?ili?ili ?ana o ka pō?ino DNA, ho?onui i nā ho?ololi genetic, a me ka wikiwiki o ka ?elemakule.

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?O ka pōkole Telomere: ?O nā Telomeres nā ka?ina hana hou ma nā wēlau o nā chromosomes e pale i ka genome mai ka pō?ino. Ho?opa?a ka Magnesium i ka hopena.

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Nā ho?ololi Epigenetic: Ho?ololi ?ia nā ho?ololi epigenetic i ka hō?ike gene me ka ?ole o ka ho?ololi ?ana i ke ka?ina DNA. Ho?oponopono ka Magnesium i nā mīkini epigenetic e like me ka methylation DNA a me ka ho?ololi histone.

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?A?ole imbalance o ka homeostasis protein: ?o ka synthesis protein a me ka ho?oha?aha?a ?ana i loko o ke kelepona hiki i kahi kaulike ikaika, i kapa ?ia ?o homeostasis protein. Ho?opili ?ia ka Magnesium i ka ho?oponopono ?ana i ka hana proteasome a me ka lysosome, a ?o ka hemahema o ka magnesium e alaka?i i ka hō?ili?ili ?ana o nā protein misfolded.

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Ka pilikia o ka ?ike mea?ai: Insulin / IGF-1 a me nā ala hō?ailona ?ē a?e e ?ike i ke kūlana mea?ai cellular a ho?oponopono i ka metabolism. ?O ka Magnesium kahi cofactor o ka insulin receptors a me ka downstream kinases, a ?o ka hemahema o ka magnesium ke kumu o ka pale ?ana i ka insulin.

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Mitochondrial dysfunction: ?O Mitochondria nā hale hana ikehu cellular, a ?o kā lākou DNA a me nā kaulahao hanu hiki ke ho?opō?ino. ?O Magnesium ka lua o ka nui o ka cation i loko o ka mitochondria, kahi i komo i ka ATP synthesis a me ka antioxidant, a ?o ka hemahema o ka magnesium e ho?onui i ka pō?ino mitochondrial.

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?O ke ?ano o ke kelepona: ho?opau nā cell senescent i ka māhele ?ana, hūnā i nā mea ?eha, a luku i ka microenvironment. Hiki i ka Magnesium ke pale aku i ka pō?aiapuni o ke kelepona i nā protein p53 a me ka p21 a ho?opane?e i ka senescence cell.

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?O ka pau ?ana o nā pūna?i kumu: ?O nā pūnaewele kumu ke kuleana no ka ho?oponopono hou ?ana a me ka ho?oponopono ?ana, a ke emi nei kā lākou helu a me kā lākou hana me ka makahiki. Ho?opilikia ka Magnesium i ka ho?oka?awale ?ana o nā cell stem hematopoietic, a ?o ka hemahema o ka magnesium hiki ke ho?olalelale i ka pau ?ana o nā cell stem.

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?O nā ho?ololi i ke kama?ilio intercellular: nā cytokines, hormones, etc. e ho?opili i ka ho?ololi hō?ailona intercellular. Ho?onui ka ?elemakule i ka huna ?ana o nā mea inflammatory. Kāohi ka Magnesium i ka mumū a ho?omaika?i i ke kama?ilio kelepona.

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?O Autophagy pilikia: He ala ko?iko?i ?o Autophagy no nā cell e ho?oha?aha?a i nā protein a me nā organelles. Mālama ka Magnesium i ka hana autophagy ma o ka ho?oponopono ?ana i ka hana o nā genes pili autophagy a me nā kinases.

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?O ka ma?i o ka ?ōpū: pili ka flora intestinal i ka metabolism nutrient a me ka ho?oponopono immune, a pili ka microbial imbalance i ka ?elemakule. Ho?oponopono ka Magnesium i ka flora gut a ho?omaika?i i ke olakino host.

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?O ka ma?i ma?amau: Ho?opili ?ia ka ?elemakule me ka ma?i ha?aha?a ha?aha?a ha?aha?a i loko o ke kino, ?o ia ho?i, "?elemakule inflammatory". ?O ka hemahema o ka Magnesium ke kumu o ka ho?oulu nui ?ana o nā ala hō?ailona inflammatory e like me NF-κB a ho?onāukiuki i ka pane inflammatory.

Wahi a ka nui o nā noi?i epidemiological a me nā ho?okolohua i ho?opa?a ?ia, ?o ka ho?onui ?ana i ka ?ai magnesium i ka mea?ai a me ka ho?omākaukau ?ana i ka magnesium hiki ke hō?emi i ka ?eha mau makahiki e pili ana i ka makahiki, ke kū ?ana o ka insulin, ka ma?i cardiovascular, a me nā mea ?ē a?e.

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?Oiai he palekana ka magnesium, pono e maka?ala ka po?e me ka lawa ?ole o ka renal, a hiki i ka nui o ka lā?au lapa?au ke ho?oulu i ka ma?i ma?i. Pono ka po?e ?elemakule e ho?omaka i ka loa?a ?ana o ka magnesium mai kā lākou mea?ai, e like me nā lau ?ōma?oma?o, nā kī?aha piha, nā nati, a me nā mea ?ē a?e.

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Nā hō?ike ho?okolohua kiko?ī a me ka ?ikepili lapa?au:

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?O nā hō?ike ho?okolohua o ka magnesium a me ka genomic stability DNA ka mea genetic o ke ola, a ?o kona kūpa?a ke kumu no ka hana ma?amau o nā cell. Ua ?ike ?ia ka noi?i ?ana aia nā ion magnesium ma waena o 50% o nā pae kumu i loko o ka DNA double helix structure, kahi mea e ho?okō ai i ka ho?opa?a ?ana i ka hale. I loko o nā mea ola ho?ohālike e like me Escherichia coli a me ka hū, ?o kahi kaiapuni magnesium ha?aha?a e ho?onui nui i nā helu kuhi hewa DNA. Ua hō?oia pū ?ia nā ho?okolohua mo?omeheu kanaka fibroblast hiki i ka magnesium ha?aha?a ke ho?opōkole i ka telomere a me ka ho?oponopono ?ana i ka hō?ike ?ana o ka DNA hō?ino pane. Ua hō?ike ?ia nā ho?okolohua holoholona ua pō?ino ka ?ōnaehana pale antioxidant i loko o ke akepa?a o nā ?iole hemahema magnesium, a ua ho?onui ?ia ke ki?eki?e o 8-hydroxy-deoxyguanosine, kahi hō?ailona o ka pō?ino oxidative DNA. Ua ?ike ?ia kahi ha?awina i nā ?iole ?o ka inu ?ana i ka wai momona magnesium i ho?olō?ihi i ka lō?ihi telomere a ho?emi i ka pō?ino DNA. Hō?ike kēia mau hopena he mea nui ka magnesium no ka mālama ?ana i ke kūpa?a genomic.

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Ma nā noi?i heluna kanaka, ua ho?opili maika?i ?ia nā pae serum a i ?ole erythrocyte magnesium me nā hō?ailona like ?ole o ka genomic instability, e like me ka micronucleus frequency, nā pae o nā huahana pō?ino DNA 8-hydroxy-deoxyguanosine, a me ka lō?ihi telomere. A cross-sectional study of almost 200 health adults found that those with the red blood cell magnesium levels had peripheral blood lymphocyte telomere longs that were, on average, 11.5% short than those with the highest magnesium pae. ?O kekahi noi?i cohort o 1800 mau makahiki waena a me nā ?elemakule ma 45-74 mau makahiki i ukali ?ia no 5 mau makahiki i ?ike ?ia ua pili maika?i ?ia ka ?ai ?ana o ka magnesium me ka degere o ka pō?ino DNA i nā lymphocytes koko peripheral ma ka papa kuhikuhi, a ?o kēlā me kēia pi?i ?ana o ka magnesium intake o 100mg / lā i ho?emi ?ia ke degere o ka pō?ino DNA ma 5.5% ma hope o 5.5% ma hope o ka 5. Hō?ike kēia i ka ho?ohui ?ana o ka magnesium i nā kānaka ke kōkua pū i ka mālama ?ana i ka genomic stability.

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?O ka lua, ?o ka pilina ma waena o ka hana o ka magnesium a me ka telomerase a me ka ?elemakule ?o Telomeres he mau hale kūikawā ma ka hopena o nā chromosomes, i haku ?ia me ka TTAGGG repeats a me nā telomere-binding proteins, ka mea e pale ai i nā chromosomes mai ka ho?oha?aha?a ?ana i ka wā o ka māhele cell. Akā i loko o nā pūnaewele kanaka, pōkole ka lō?ihi o ka telomere e 50 a 100 mau papa kumu no kēlā me kēia mahele, a i ka wā e hiki ai ka pōkole i kahi waiwai ko?iko?i, komo ke kelepona i kahi kūlana o ka ?elemakule. ?O Telomerase kahi ribonucleoprotease e ho?olō?ihi i ke ka?ina telomere, akā ?a?ole i hō?ike maika?i ?ia a ?a?ole i hō?ike ?ia i loko o nā pūnaewele makua.

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I loko o ka ?iole embryonic fibroblasts (MEF), ha?aha?a magnesium ha?aha?a emi telomerase hana ma mua o 50% a hō?ike cellular senescence hi?ona, e like me ka ho?onui β-galactosidase hana a me ka up-regulated hō?ike o cell pō?aiapuni inhibitors p16 a me p21. Hiki ke ho?ohuli ?ia kēia mau phenotypes kahiko ma hope o ka mālama ?ana me ka magnesium a i ?ole telomerase activators. Ua ?ike ?ia nā hopena like i nā cell endothelial kanaka a me nā fibroblasts. Ua ?ike ?ia nā ha?awina molecular mechanical e hiki i ka magnesium ke ho?oponopono i ka lō?ihi o ka telomere ma o ka ho?opili ?ana i ka ?ōlelo a me ka localization o kekahi mau protein kī i loko o ka telomere complex, e like me TRF1 a me TRF2. Eia hou, hiki i ka magnesium ke ho'āla i nā ala hō?ailona e like me AKT a me ERK, a ke?ake?a i nā mea ho?opane?e pō?ai cell e like me p53 a me Rb, a laila e ho?opane?e i ka ?elemakule.

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Kāko?o pū nā ha?awina lā?au lapa?au i kahi loulou ma waena o ka magnesium a me ka senescence cellular. Ma mua o 100 mau po?e ?elemakule olakino, ua ho?opili maika?i ?ia nā pae magnesium serum me ka ho?onui ?ana o T lymphocyte a ho?opili maika?i ?ia me nā pae plasma p16. ?O kekahi noi?i ?ē a?e he 250 po?e ?elemakule ma ke kaiāulu, a ?ike ?ia ua pili pili nā pae o ka magnesium serum baseline i nā loli i nā hō?ailona o ka ?elemakule e like me ka paepae lohe, ka ikaika pa?a, a me ka wikiwiki o ka hele ?ana, e hō?ike ana e pili ana ke kūlana magnesium i ke ka?ina hana ?elemakule holo?oko?a i ke kino. Ua ho?ohālikelike kahi ha?awina o ka po?e ma mua o 2,000 ma luna o ka makahiki 70 i nā pae serum magnesium like ?ole me ka 10-makahiki pilikia o ka make a ?ike ?ia ?o ka hui me nā ha?aha?a magnesium ha?aha?a he 2.2 mau manawa ?oi aku ka nui o ka make ma mua o ka hui me nā pae ki?eki?e. ?Oiai ?a?ole hiki i kēia mau ha?awina nānā ke hō?oia pololei i ke kumu a me ka hopena, kāko?o lākou i kahi hui ikaika ma waena o ka magnesium a me ka ?elemakule mai kahi hi?ohi?ona heluna kanaka.

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?O ke kuleana o ka magnesium i ke ala hō?ailona insulin ?o Insulin ka hormone ho?oponopono kumu o ka homeostasis glucose koko kanaka. Ma hope o ka ho?opa?a ?ana o ka insulin i kāna mea ho?okipa, hana ia i ka phosphorylation pono?ī o ka mea loa?a, a ho?āla i kahi ?ano o nā kinases protein downstream e like me PI3K a me AKT, a ho?oponopono hope i ka ?ōlelo o nā genes e pili ana i ka metabolism glucose. Ua hō?ike ?ia nā ho?okolohua he nui i ka hana ko?iko?i o ka magnesium i nā ?anu?u a pau o ka hō?ailona insulin. 1. I loko o nā pūnaewele beta islet, ho?okumu ka magnesium i ka MgATP complex me ATP e komo i ke ka?ina holo?oko?a o ka synthesis insulin, ka hana a me ka huna. I ka ?iole a me ka ?iole beta cell line, ha?aha?a-magnesium medium i ho?emi i ka glucose-ho?oulu ?ia o ka insulin huna ma mua o 70%. 2. I loko o ka insulin target cell, tyrosine kinase hana o ka insulin receptors pili i ka magnesium ions, a me ka magnesium deficiency alakai i ka insulin receptor phosphorylation a downstream signal transduction obstruction, ka hopena i ka insulin resistance. I loko o 3T3-L1 adipocytes a me L6 skeletal muscle cell, ha?aha?a-magnesium medium hoemi i ka insulin-ho?oulu glucose uptake e 40% a 60%. 3. Ho?okomo pū ka Magnesium i ka ho?oponopono ?ana i ka na?au o ka insulin ma ke kāohi ?ana i ka protein phosphatase, ka ho?oponopono ?ana i ka hō?ike integrins, e pili ana i ka hana transporter GLUT4 a me nā hana ?ē a?e. Ua hō?ike kekahi mau ho?okolohua holoholona i ka ho?onui ?ana i ka mea?ai ma?alahi o ka magnesium e ho?omaika?i i ka pale ?ana o ka insulin i nā ?iole ma?i ma?i momona a me ke ?ano 2.

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Kāko?o nā ha?awina epidemiological i ka pilina pili ma waena o ka magnesium a me ka metabolism glucose. ?O ka US Nurses' Health Study, kahi kokoke i 70,000 mau wahine ma luna o ka makahiki 45 i ukali ?ia ma mua o 20 mau makahiki, ?ike ?ia ?o ka po?e i ka quintile ki?eki?e o ka ?ai magnesium mea?ai he 27% ha?aha?a ha?aha?a o ka ho?omohala ?ana i ka ma?i diabetes type 2 ma mua o ka po?e i ka quintile ha?aha?a. Ua hō?ike ?ia kahi meta-analysis o nā ha?awina cohort 25 e pili ana ma kahi o 1 miliona mau mea komo i kēlā me kēia 100mg / lā ho?onui i ka lawe ?ana i ka magnesium mea?ai e pili ana me ka 8% a 13% ka emi ?ana o ka ma?i diabetes type 2. I loko o ka po?e me ka ma?i ma?i ma?i i kēia manawa, pili pū ka ho?emi ?ana o ka pae magnesium serum i ka pi?i ?ana o ka ma?i a me nā pilikia. Ua ?ike ?ia kahi noi?i o nā mea ma?i ma mua o 300 me ka ma?i diabetes type 2 he ha?aha?a ha?aha?a ka pae o ka magnesium serum i ka po?e me ka ma?i na?au coronary ma mua o ka po?e me ka ma?i diabetes wale nō. I ka hopena, ua hō?ike ka nui o nā ha?awina e hiki ke ho?opane?e ka ho?onui ?ana o ka magnesium i ka ?elemakule ma o ka ho?omaika?i ?ana i ka insulin resistance.

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4. ?O ka hemahema o ka Magnesium a me ka mitochondrial dysfunction ?O Mitochondria nā wahi nui o ka hana ?ana o ka ikehu cellular a me ka hana ?ana o nā ?ano oxygen reactive (ROS). I ka wā o ka wā kahiko, emi iho ka maika?i o ke kaulahao transport electron mitochondrial a ho?onui ka ROS production, e ho?one?e ai i ka mutation mtDNA, membrane lipid peroxidation a me nā mea pō?ino ?ē a?e, e hana ana i kahi pō?ai?ino a me ka wikiwiki o ka ?elemakule. Ua ?ike nā ha?awina ?o ka hapakolu o ka magnesium i loko o ke kino e mālama ?ia i ka mitochondria, he mea nui ia no ka mālama ?ana i ke ?ano mitochondrial a me ka hana. I loko o ka ?iole ate mitochondria, ?eiwa o nā subunits 13 o adenosine triphosphatase e koi i ka magnesium ma ke ?ano he cofactor. I loko o ka myocardial mitochondria, hiki i ka magnesium ha?aha?a ke ho?emi nui i nā hana o nā enzymes nui i loko o ka pō?ai tricarboxylic acid, e like me isocitrate dehydrogenase a me α-ketoglutarate dehydrogenase. I ka ?iole ate mitochondria, hiki i ka magnesium deficiency ke ho?emi i ka helu ATP synthesis ma mua o 60%, ho?emi i ka nui o ka mana hanu, a ho?onui i ka hana ROS, ka hopena i ka nui o ka pō?ino mtDNA a me ka helu mutation. Hiki i ka ho?onui ?ana i ka magnesium ke ho?ohuli i kēia mau hana mitochondrial. I loko o nā ?i?o ?i?o iwi iwi a me nā cardiomyocytes, hiki i ka magnesium ha?aha?a ke depolarize i ka hiki o ka membrane mitochondrial, ho?oulu i ka wehe ?ana o ka mitochondrial permeability transition pore (mPTP), ho?oulu i ka ho?oku?u ?ana o ka cytochrome C, a hiki i ka apoptosis. I loko o nā pūnaewele endothelial vein umbilical, ho?oulu ka magnesium ha?aha?a i ka nui o ka mitochondrial ROS ma o ka ho?oulu ?ana i ka protein kinase C, e alaka?i ana i ka endothelial dysfunction. Ua ?ike ?ia kahi noi?i o nā mea ma?i ?oi aku ma mua o 100 me ka metabolic syndrome i ho?opili maika?i ?ia nā pae serum magnesium me ka hana hanu mitochondrial a pili maika?i ?ole me nā pae mitochondrial ROS. I ka hō?ulu?ulu?ana, hō?ike nā hō?ike i luna nei he mea nui ka magnesium i ka mālama?ana i ka homeostasis mitochondrial, a?o ka dysfunction mitochondrial kekahi o nā mea nui o ka?elemakule.

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?O ka lima, ?o ka hana ho?oponopono o ka magnesium ma ka ?ā?ī ?ana a me ka ?elemakule pale ?O ka ma?i ha?aha?a ha?aha?a ha?aha?a kekahi mea nui o ka ?elemakule. Ua ?ike nā ha?awina e ho?onui nui ?ia nā pae o nā mea inflammatory e like me IL-6 a me TNF-α i ka po?e ?elemakule, ?oiai ke emi nei nā pae o nā cytokine anti-inflammatory e like me IL-10, a ua ?ike ?ia kēia mau ma?i inflammatory ma?i ma muli o ka ?elemakule. Hiki i ka ?elemakule inflammatory ke ho?opō?ino i ka ?i?o a me ke kaulike ?ole, ?o ia ke kumu pathological o nā ma?i ma?i he nui. Ua hō?ike ?ia nā ha?awina ho?okolohua e hiki i ka hemahema o ka magnesium ke ho?oulu i ka pane inflammatory a me ka pale ?ole. Ma ka mo?omeheu macrophage ?iole, hiki i ka magnesium ha?aha?a ke ho?oponopono i ka hana NF-κB a ho?oikaika i ka ho?oku?u ?ana i nā mea ?eha. I loko o nā pūnaewele epithelial bronchial o nā?iole, hiki ke ho?onui ?ia ka huna ?ana o IL-6 a me IL-8 e 2 a 3 mau manawa ma o ka ho?oulu ?ana o LPS ma lalo o ke kaiapuni magnesium ha?aha?a. I loko o nā pūnaewele endothelial kanaka, hiki i ka magnesium ha?aha?a ke ho?oikaika i ke ala hō?ailona p38 MAPK, e ho?oulu i ka hō?ike o nā molekele adhesion intercellular, a ho?onui i ka pane inflammatory. I nā?iole nele i ka magnesium, ua ho?onui nui?ia nā ki?eki?e o TNF-α, CRP a me interleukin i ke ka?a a me nā?i?o, ua atrophy nā kino kino, ua emi ka helu a me ka hana o nā lymphocytes T a me B, a ua ho?onui?ia ka immunosuppression. Hiki i ka ho?ohui ?ana o Magnesium ke hō?olu?olu maika?i i kēia mau ma?i ?eha a me ka pale. Ua ?ike pū ?ia nā ha?awina lā?au lapa?au e pili pono ana ka magnesium ha?aha?a i ka mumū mau. A cross-sectional study of more than 5,000 adults in the United States found that serum magnesium concentration was significantly negatively correlated with CRP and white blood cell counts, and CRP and IL-6 pae ma ka ha?aha?a quartile o ka magnesium pae he 60% a me 40% ki?eki?e ma mua o ka poe ma ka quartile ki?eki?e. Ua ?oi aku ka ikaika o ka pilina i ka po?e pa?a. ?O kekahi noi?i ?ana o 3,200 po?e ma luna o ka makahiki 65 ua ?ike ?ia ua pili maika?i nā pae serum magnesium me ka lō?ihi telomere koko ke?oke?o a pili ?ole i nā pae CRP a me D-dimer. A meta-analysis o 25 randomized controlled trials with a total sample size of more than 2,000 people show that oral magnesium supplementation hoemi serum CRP pae ma ka awelika o 22%, TNF-α e 15%, a me IL-6 e 18%. No laila, hiki i ka magnesium supplementation ke ho?opane?e i ka ?elemakule kino ma o nā hopena anti-inflammatory.

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?O ka pilina ho?oponopono ma waena o ka magnesium a me autophagy ?O Autophagy kahi hana ko?iko?i no ka ho?oha?aha?a cell a me ka wehe ?ana i nā protein a me nā organelles i hō?ino ?ia, a he mea ko?iko?i ia no ka mālama ?ana i ka homeostasis o ke kaiapuni cellular. Ua hō?ike ?ia nā ha?awina e ho?onāwaliwali mālie ?ia ka hana autophagy i ka wā ?elemakule, a hiki i nā hemahema i ka autophagy ke ho?oulu i ka protein aggregation, mitochondrial dysfunction, etc. ?O Magnesium, ma ke ?ano he ?elele ?elua, pili i ka ho?oponopono ?ana i ka ho?omaka a me ke ka?ina o ka autophagy. I ka hū, ho?opau ka magnesium deficiency i ka hō?ike ?ana o nā genes pili autophagy Atg1 a me Atg13 ma ka ho?oulu ?ana i ke ala hō?ailona TORC1. I loko o nā pūnaewele mammalian, hiki i ka ha?aha?a magnesium ha?aha?a ke kāohi i ka hana o ULK1, Beclin1 a me nā mea ?ē a?e autophagy ho?omaka i nā protein, a pale i ke kūkulu ?ana i nā autophagosomes. I loko o ke kanaka embryonic kidney cell, magnesium ion chelating agent EDTA hiki ke kāohi i ke kahe autophagy. Ua hō?ike ?ia nā ho?okolohua in vitro e hiki ke ho?opa?a a ho?ōla i ka Atg4, kahi enzyme proteolytic e pono ai no ka maturation autophagosome. Ua ?ike pū ?ia nā ha?awina holoholona e hiki ke ho?emi i nā ma?i autophagy ma nā neurons a me cardiomyocytes, ho?omaika?i i ka hana cognitive a me ka hana systolic cardiac. ?Oiai ?a?ohe hemahema o nā hō?ike lapa?au pololei, hō?ike kekahi mau ha?awina nānā i ka pilina ma waena o ka magnesium a me ka autophagy. Ho?opili maika?i ?ia nā pae Magnesium me ka hō?ike ?ana o nā māka autophagy Atg5 a me Beclin1 i loko o ka lolo a me ke koko peripheral mononuclear cell o nā mea ma?i me ka ma?i o Alzheimer. I nā po?e ma?i me ka ma?i ma?i type 2, pili loa ka ho?onui ?ana o ka magnesium serum i nā pae hō?ike o nā genes pili autophagy LC3 a me p62. I ka hopena, hiki i ka magnesium ke pā?ani i kahi hana ko?iko?i i ka pale ?ana i ka ?elemakule ma ka ho?oponopono ?ana i ka autophagy. Akā, pono e a?o hou ?ia kāna mīkini kiko?ī.

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7. Interaction ma waena o Magnesium a me ka intestinal flora Intestinal flora he "organ" ko?iko?i i loko o ke kino o ke kanaka, e pā?ani ana i kahi mea hiki ?ole ke ho?ololi i ka metabolism nutritional, ka ho?oponopono immune, neuroendocrine a me nā mea ?ē a?e. Ua ?ike ?ia nā noi?i hou e pili pono ana nā loli i ka haku mele ?ana a me ka hana o ka gut microbiota i ka ?elemakule. No ka la?ana, ua emi nui ka hapa o nā firmicutes a me nā Bacteroides i loko o ka ?ōpū o ka po?e kahiko, a?o ka nui o nā pathogens opportunistic e like me enterococcus a me Staphylococcus i ho?onui ?ia. Hiki i kēia ?ano like ?ole o ka pua ke hō?ino i ka pā o ka ?ōpū, ho?oikaika i ka ho?oku?u ?ana o nā mea ?eha, a ho?onui i ka ?eha mau i ke kino holo?oko?a.

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Ma ke ?ano he substrate mea?ai ko?iko?i i ka ?ōpū, hiki i ka magnesium ke ho?opili i ka ho?ohui ?ana o ka flora ma o nā ?ano hana like ?ole. I nā ?iole germ-free, hiki i ka inu wai momona i ka magnesium ke ho?onui nui i ka helu o nā hua bacteria maika?i e like me ka bifidobacterium a me Bacteroides, a ho?emi i ka waiwai pH o ka ?ōpū. I loko o kahi ki?i ?iole o ka colitis, ua ho?emi ?ia ka ho?ohui ?ana o ka magnesium i nā mea ulu lā?au ?ōpū a ke?ake?a i ka hana NF-κB i ke ala hō?ailona inflammatory. I nā ho?okolohua kanaka olakino, ua ho?onui ?ia ka hapa o ka bifidobacteria i loko o nā feces ma hope o 8 mau pule o ka ho?ohui ?ana o ka magnesium, a ua emi nā pae o ka lipopolysaccharide, D-lactic acid a me nā metabolites bacterial ?ē a?e. Ua ?ike pū kekahi mau noi?i preclinical hiki i ka hemahema o ka magnesium ke ho?opau i nā hui pa?a o ka ?ōpū, ho?onui i ka permeability, a hana i nā kūlana no ka unuhi ?ana o nā endotoxins enterogenic.

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Hiki i ka Magnesium ke ho?opili i ke ka?ina hana kahiko o ka mea ho?okipa ma o ka ho?oponopono ?ana i ka metabolism bacteria. No ka la?ana, ho?oulu ka magnesium i ka hana ?ana i nā ?akika momona pōkole e like me Bifidobacterium, ka mea e ho?āla ai i ka G-protein-coupled receptor GPR43, ka mea e pale ai i ka ?eha pili i ka momona a me ka ho?oikaika insulin. Eia kekahi, hiki i ka magnesium ke ho?opili i ka waikawa bile a me ka metabolism tryptophan, a ?o nā ma?i o kēia mau ala ?elua e pili kokoke ana i ka ?elemakule a me nā ma?i neurodegenerative. I ka hopena, mana?o ?ia ka magnesium he ho?olālā hou no ka ho?opane?e ?ana i ka ?elemakule ma ka ho?oponopono hou ?ana i ka flora intestinal a me ka ho?oponopono ?ana i ka axis bacteria-gut-brain, akā pono e hō?oia ?ia kona hopena lō?ihi e nā ha?awina cohort prospective.

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I ka hō?ulu?ulu mana?o, hō?ike ka nui o nā hō?ike ho?okolohua a me nā ma?i epidemiological he mea ko?iko?i ka magnesium e pale aku i ka ?elemakule a hāpai i ke olakino a me ka lō?ihi. Ho?opili ia i ka ho?oponopono ?ana i ka ?elemakule ma o nā ?ano hana penei:

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?Oiai ?a?ole maopopo ka hopena o ka ho?ohui ?ana o ka magnesium i ke ola o ke kanaka, hō?ike ?ia nā hō?ike ?ike ?ole e hiki i ka magnesium ke kōkua i ka ho?opane?e ?ana i nā phenotypes kahiko a ho?omaika?i i nā mana?olana olakino. I ka wā e hiki mai ana, pono nā noi?i cohort prospective a me nā ho?okolohua ho?okele randomized no ka ho?oma?ama?a hou ?ana i nā hopena anti-aging o ka magnesium a me kāna pilina hopena-hopena, i mea e hā?awi ai i nā hō?ike hō?ike no ka ho?okumu ?ana i nā ho?olālā ho?ohui magnesium. Eia kekahi, ?a?ole like ke kūlana mea?ai magnesium a me ke koi ?ana o nā lāhui like ?ole, no laila, ?o ka ho?okumu ?ana i ka papahana ho?ohui magnesium ho?okahi he pilikia ko?iko?i e ho?oponopono ?ia. Mana?o ?ia me ka ho?omohala ?ana i ka lā?au lapa?au a me ka mea?ai, e wehe mākou i nā mea huna a pau o kēia mea ho?okalakupua magnesium, a ho?ohana iā ia e hakakā i ka ?elemakule a ?ike i ka moe?uhane o ke ola lō?ihi.

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