?O ka HMB kahi metabolite waena o ka leucine amino acid pono kanaka, a hiki i ke kino o ke kanaka ke hana i kahi li?ili?i o ka HMB pono?ī. Ma kahi mea?ai ma?amau, ho?opuka ke kino o ke kanaka ma kahi o 300 a 400 mg i kēlā me kēia lā, kahi o 90% e hele mai mai ka catabolism o leucine. Hiki ke ho?ohana ?ia ka HMB no ka ho?oikaika ?ana i ka ulu ?ana o ka ?i?o, ho?omaika?i i ka pale ?ana, ho?emi i ka cholesterol a me ka lipoprotein ha?aha?a ha?aha?a i ke kino e hō?emi ai i ka hiki ?ana o ka ma?i coronary heart a me ka ma?i cardiovascular, akā e ho?oikaika pū i ke kino o ka nitrogen fixation hiki, mālama i nā pae protein i loko o ke kino, a pale i ka pala o ka ?i?o i nā mea ma?i moe a ma?i ma?i. I nā makahiki i hala iho nei, no ka mea hiki iā ia ke hō?emi i ka pō?ino o ka ?i?o ?i?o ma hope o ka ho?oma?ama?a ?ana, ho?oponopono i nā ?i?o ?i?o, ho?onui i ka ikaika o ka ?i?o a puhi i ka momona o ke kino, ua lilo ia i mea ho?ohui i nā huahana mea?ai ha?uki. Eia kekahi, ua hō?oia ?ia ?o HMB e ho?olalelale i ka hō?eha ?ana a me ka pale ?ana i ka mumū. Ua hō?ike nā ha?awina e hiki iā Ca HMB ke ho?olalelale i ka synthesis protein a ho?olohi i ka ho?ohana ?ana i ka protein. ?O Ca HMB i hui pū ?ia me ka glutamine a me ka arginine hiki ke ho?omaika?i i ke koena nitrogen maika?i ?ole o nā mea ma?i a pā?ani i kahi hana maika?i i ka ho?iho?i ?ana mai ka trauma a me ke ?oki.

I ka makahiki 2011, ua ho?olaha mua ke Kuhina Ola o Kina i ka ?ae ?ana o ka calcium β-hydroxy-β-methylbutyrate (Ca HMB) i mea?ai waiwai hou, ka ho?ohana ?ana i nā mea?ai mea?ai ha?uki, nā mea?ai lā?au lapa?au kūikawā, ?o ka nui i ?ōlelo ?ia he ≤3 grams / lā. I ka makahiki 2017, ua ho?olaha ka National Health and Family Planning Commission i ka ho?onui ?ana i ka laulā noi o Ca HMB mai nā noi ?elua i ?eiwa, a ua kauoha ?ia nā ?enehana loiloi loiloi e hana i nā loiloi palekana. Ua ho?onui ?ia ka ho?ohana ?ana o Ca HMB e komo i nā mea inu, ka waiū a me nā huahana waiu, nā huahana koko, nā kokoleka a me nā huahana kokoleka, nā candy, nā mea i ho?omo?a ?ia, a me nā mea?ai mea?ai kūikawā, a ?o ka nui i ?ōlelo ?ia ?o ≤3 g / lā, ?a?ole i ?oi aku ma mua o ke ?ano o nā mea manawale?a ho?okolokolo kanaka. Ua ?ike ?ia ?o Ca HMB ?o GRAS e ka US Food and Drug Administration ma 1995 a ho?ohana ?ia i nā mea?ai olakino olakino a me nā mea?ai kūikawā. I nā makahiki he 20 i hala iho nei, ua ho?ohana nui ?ia ?o Ca HMB i nā huahana waiu, nā huahana kokoleka, nā mea inu, nā pahu ikehu a me nā mea?ai ?ē a?e ma ka mākeke US. ?O Ca HMB kahi mea?ai maka i ?ae ?ia e nā lula Iapana, hiki ke ho?ohui ?ia i nā ?ano he nui e like me ka mea?ai ma?amau, nā mea?ai mea?ai ha?uki, nā mea?ai pohō kaumaha, nā mea?ai nani, a me nā mea ?ē a?e. No nā mea hana a me nā lā?au lapa?au, ?o Ca HMB kekahi o nā mea olakino kaulana loa ma ka mākeke Iapana.