?O Lycopene (LYC), he carotenoid, he pua?a momona momona, ?ike nui ?ia i loko o nā ?ōmato, ?alawai, hua waina a me nā hua?ai ?ē a?e, ?o ia ka pua?a nui i nā tōmato pala. Loa?a i ka Lycopene nā pono olakino like ?ole, e komo pū ana me ka ho?oka?awale ?ana i nā radical manuahi, ho?oma?ama?a i ka mumū, ho?oponopono i ka glucose a me ka lipid metabolism, a me nā hopena neuroprotective.

I kēia mau lā, ua ho?opuka nā mea noi?i mai Shanxi Medical University i kahi pepa i loko o ka puke pai Redox Biology i kapa ?ia "Lycopene alleviates age-related cognitive deficit via activating ate-lolo. Research pepa o ka fibroblast ulu factor-21 hō?ailona ".

Ua hō?ike ?ia nā ha?awina ?o ka ho?ohui ?ana me ka lycopene no nā mahina 3 hiki ke ho?opane?e i ka ?elemakule o ka lolo i nā ?iole a ho?oha?aha?a i ka pō?ino cognitive pili i ka makahiki, a ho?omaika?i ?o lycopene i ka degeneration neuronal, mitochondrial dysfunction, synaptic damage, a paipai i ka synaptic vesicle fusion i nā ?iole kahiko.

Eia kekahi, ua ho'āla ka lycopene i ka axis liver-brain axis FGF21 e hō?ailona ana i nā ?iole kahiko, a laila e ho?oikaika ana i ka ho?oku?u ?ana o nā neurotransmitters ma o ka ho?onui ?ana i nā pae mitochondrial ATP a me ka ho?onui ?ana i ka synaptic vesicular fusion. Hō?ike kēia e hiki i ka FGF21 ke lilo i mea lapa?au i nā ho?olālā ?ai mea?ai e ho?opane?e i ka ?elemakule o ka lolo a ho?omaika?i i ka pilikia cognitive pili i ka makahiki.

I ka ?elemakule, ka lolo o ka lolo, ka mitochondrial dysfunction kekahi o nā mea nui loa, ua ?ike nā mea noi?i e hiki i ka lycopene supplementation ke ho?omaika?i i ka pō?ino morphological mitochondrial, a ho?ohuli i ke ki?eki?e o ke kaulahao transport electron mitochondrial i ho?okumu ?ia e ka ?elemakule, e ho?oikaika i ka hana ?ana o ATP, e hō?ike ana he hopena pale ka lycopene i ka hana mitochondrial.

?O ka mea hope loa, ua hana pū nā mea noi?i i nā ho?okolohua in vitro a ?ike ?ia ua ho?onui ka lycopene i ka hiki o nā pūna?i ate ke kāko?o i nā neurons, me ka ho?omaika?i ?ana i ka ?elemakule cell, ho?onui i ka hana mitochondrial, a me ka ho?onui ?ana i ka lō?ihi o ka neuron axon.

Ho?ohui pū ?ia, hō?ike nā hopena e hiki i ka lycopene supplementation ke ho?opane?e i ka ?elemakule o ka lolo a pale i ka hō?ino ?ana o ka na?au pili i ka makahiki i nā ?iole, ma kahi ?āpana no ka lycopene ho?āla i ka hepato-brain axis FGF21 hō?ailona, ??e hō?ike ana he hiki i ka FGF21 ke kumu therapeutic kūpono i nā mea?ai mea?ai e ho?omaika?i ai i nā ma?i neurodegene e pili ana i ka makahiki.