(1) Nā mea ola maoli

Ma ke?ano he monosaccharate maoli, loa?a ka mannose i loko o ka epidermis o nā'ōla?a (0.7-1.2%) a me nā?alani (0.3-0.8%). ?O ? kona ?ano mole. C?H??O? a me ka glucose ?. 8. I ka wā o ka metabolism kanaka, komo ka mannose i nā pūnaewele ma o kahi transporter kiko?ī, GLUT1, akā ?a?ole ia e ho?āla i ka ?ōnaehana huna huna insulin, kahi waiwai e ho?olilo ai i kahi koho momona palekana no ka ma?i ma?i ?78.

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(2) Ke pi?i a?e o nā mea?ai hou

I ka makahiki 2023, ua helu ka National Health Commission i ka konjac mannose oligomeric ma ke ?ano he mea?ai maka hou, e hō?ailona ana i ke komo ?ana o ka mannose i loko o ke kahua noi ?oihana mea?ai ?7. ?O ka degere o ka polymerization o ka mannose oligosaccharide i loa?a e ka enzymatic hydrolysis o konjac glucomannan i ho?omalu ?ia i loko o 2-10 kōpa?a kō, ?a?ole ia e mālama wale i nā waiwai kūlohelohe akā loa?a pū kekahi i ka ho?oponopono ?ana. Ua ho?ohana ?ia ?o 7 ma mua o 20 mau ?ano mea?ai e like me nā mea inu ?ole ke kō a me nā kuki hana.

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?O ka lua, ?o ka hana ho?oikaika olakino o ka mannose

(a) ka pale kūlohelohe o ka ?ōnaehana urinary tract

Hō?ike ka ?ikepili ma?i i ka 2g o ka mannose i kēlā me kēia lā hiki ke hō?emi i ka nui o ka ma?i ?ana o ka ma?i urinary tract i nā wahine ma 38%?8. ?O kāna ?ano hana me:

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? ho?oma?ema?e kino ? : Ho?oku?u ?ia ka 90% o ka ?ai ma o ka urethra i loko o 30-60 mau minuke, a ho?oku?u ?ia nā bacteria pathogenic (e like me E. coli) mai ke kino ?8;

? biofilm cracking ? : ho?opau i ka β-1, 4-glucoside bond o bacterial biofilm, ho?omaika?i i ka pono bactericidal o nā lā?au antibiotic ma 3 manawa ?78;

? ho?oponopono ho?oponopono ? : ho?oikaika i ka huna ?ana o ka defensin e nā pūnaewele epithelial urethral, ??ho?onui i ka palekana kūloko ?8.

(2) ?O ke kahu ?ike ?ole ?ia o ke olakino ?ōpū

Hiki i ka Konjac mannooligosaccharide ke ho?onui i nā probiotics e like me ka bifidobacterium, a ho?onui i ka nui o ka flora intestinal e 25%?7. I loko o kahi ho?okolohua lapa?au ma Wuhan Union Medical College Hospital, ma hope o ka lawe ?ana i ka mannose oligosigro no 4 mau pule, ua ho?onui ?ia ka pinepine o ka ho?ohemo ?ana o ka ?ōpū mai ka 2.3 a i ka 4.1 mau manawa i kēlā me kēia pule, a ua ho?emi ?ia ka ma?i o ka ?ōpū o ka ?ōpū e 62%?7.

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(3) He mea hana no ka pale ?ana a me ka mālama ?ana i nā ma?i metabolic

?A?ole like me nā mea ?ono hana, he glycemic index (GI) ka mannose, a ?o ka ho?ololi ?ana i ka sucrose i loko o nā mea?ai i ho?omo?a ?ia, ua ho?emi ?ia ka nui o ke kō koko postprandial e 2.1mmol/L i nā ma?i ma?i ma?i 78. Ua hō?oia ?ia kahi ha?awina 2024 Journal of Nutrition e ho?omaika?i ka mannose i ka ho?omanawanui glucose impaired i nā ma?i kū i ka insulin ?7 ma ka ho?āla ?ana i ke ala AMPK.

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3. Nā hana hou i ka ?oihana mea?ai

(1) Nā la?ana o ka ho?omohala ?ana i ka mea?ai hana

? nā mea inu ho?omalu mimi ? : 500mg/ ?ōmole o ka mannose oligosaccharide i ho?ohui ?ia i kahi mea inu cranberry pa?akikī o kekahi brand, a ?oi aku ka nui o ke kū?ai aku ma mua o 2 miliona mau hihia i ka hapa mua o ka makahiki ?7;

? ka palaoa ho?opa?a kō ? : ?o ka berena pani pani i hana ?ia me ka konjac a me ka mannose-oligosaccharide he 45% ka li?ili?i o ka carbohydrate a ?ekolu mau manawa o ka fiber ?7;

? Nutrition fortification no nā keiki ? : ?O nā lā?au kī?aha me ka mannose i ho?ohui ?ia e hiki ke ho?oikaika i ka nui o ka absorption calcium e 18%, i ho?okomo ?ia i loko o 30% ?ōnaehana mea?ai kindergarten ?7.

(2) Nā holomua i ka hana ?enehana ?enehana

?O ka ?enehana hydrolysis enzymatic kuhikuhi i ho?omohala ?ia e nā ?oihana Hubei ua ho?onui i ka helu ho?ololi o konjac glucomannan mai 58% a i 92%, a ho?emi i ke kumukū?ai hana e 40%?7. ?O ka ho?ohana ?ana i ke ka?ina hana microencapsulation ua ho?onui i ka pa?a o ka mannose i 60 mau minuke ma 120 ℃, a ho?onui i kāna noi ma ke kahua o ka bakena ?78.

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4.Scientific cognition a me ka ho?ohana pono

(1) ?O ke Kumukānāwai gula o ka mālama ?ana

? Paepae palekana ? : ?A?ole ?oi aku ka nui o ka ?ai ho?okahi ma mua o 3g, mālama ?ia ka ?ai ?ana i kēlā me kēia lā i loko o 5g, ?oi aku ka nui o ka ho?oulu ?ana o ka ?ōpū, ka ma?i ma?i (ma kahi o 7%) ?8;

? special population warning ? : renal insufficiency, excretion rate emi i ka 50%, pono e hoohana ?8 ma lalo o ke alakai a ke kauka;

? Synergistic scheme ? : I hui pū me ka cranberry extract, ho?onui ka hopena antibacterial e 2.3 manawa ?8.

(2) ?O ka ulu ?ana o ka ?oihana o ka hō?ailona ma?amau

Pono nā Rula Nui no ka Lepili Nutrition o nā mea?ai i ho?opa?a ?ia i ho?ololi ?ia i ka makahiki 2024:

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E kaha ?oko?a ?ia ka mannose ma ka papa inoa mea?ai a ?a?ole e hui pū ?ia me ka hua?ōlelo nui "sweetner" 7;

Pono e hō?ailona ?ia nā koi hana "?a?ole no ka lā?au lapa?au ?ē a?e" 8;

Pono e hō?ailona ?ia ka nui ≥1g/100g "hiki ke hō?eha i ka ?ōpū li?ili?i "7.

1. Nā ho?opa?apa?a a me nā mea e hiki mai ana

(1) Ke nānā aku nei i ka ho?opa?apa?a

? Nā hopena lō?ihi e nānā ?ia ? : ?a?ole maopopo nā hopena lō?ihi o ka ho?ohana mau ?ana no nā makahiki ?oi aku ma mua o 5 ma luna o nā pua ?ōpū ?7;

? Naturalness ? : Inā ho?ololi ke ka?ina hana hydrolysis enzymatic i nā waiwai ko?iko?i o nā mea mea e kumu ai ke kūkākūkā ha?awina ?7;

? Ka hopena o ke kaulahao kaiaola ? : ?O ka ho?onui ?ana i ka mahi?ai ?o Konjac ua alaka?i i ka ho?ololi ?ana o 30% o ka ?āina kanu ku?una, hiki ke ho?opilikia i ka biodiversity ?7.

(2) Ke kuhikuhi o ka ho?omohala ?enehana

? ka ho?ohana pono ? : Ho?omohala ?ana i nā mea ho?ohehe?e mannose i kiko?ī i nā ?ano ?oko?a ?8;

? hana ?ōma?oma?o ? : ?O nā ?ano Konjac i ho?omaika?i ?ia e ka ?enehana CRISPR, pi?i ka ?ike o ka glucomannan mai 60% a i 85%?7;

? Māka?ika?i na?auao ? : ?O nā mea hiki ke ho?ohana ?ia e nānā i ka ?ike ?ana i ka urinary mannose i ka manawa maoli no ka ho?ohui pilikino ?8.

Ka hopena

Ma ke?ano he kumu ho?ohālike o ka ho?ohui?ana o ke?ano a me ka?enehana,?a?ole wale ka mannose e ho?omau i ka na?auao kahiko ma lalo o ka lā?au apple, akā, e ho?omālamalama i ka mālamalama o ka?enehana mea?ai hou. Ma lalo o ke alaka?i ?ana o ka ho?olālā Healthy China 2030, ke ho?ololi hou nei kēia mea hana a palekana i nā palena o ka ?ike o ka po?e i nā mea ho?ohui mea?ai. Eia nō na?e, pono e ho?omaopopo i ka ho?ohana pono ?ana o kekahi mea ho?ohui e pono e ho?okumu ?ia ma ka ?ai kaulike, e like me ka "Unavoidable Food Additives" i ?ōlelo ai: "Ua ho?onui ka ?epekema a me ka ?enehana i ka mea?ai, akā ?o ka mahalo i ke ?ano ke kumu o ka ?oihana mea?ai.