Citicolineua ho?ohana nui ?ia i ka ho?oma?ama?a lapa?au, ka mea nui no ka mālama ?ana i nā sequelae neurological i hana ?ia e ka ?eha craniocerebral a i ?ole ka ulia cerebrovascular, a ua loa?a i nā ho?ohana hou i ka hana lapa?au. ?O kāna mālama ?ana i ka hemorrhage cerebral, ma?i Parkinson, glaucoma, neuropathy peripheral diabetic a me ka tinnitus a me nā ma?i ?ē a?e i ho?onui nui ?ia. No laila he aha ka citicoline, he aha nā hopena pharmacological, kona mau hō?ailona (ka mālama pono ?ana i nā ma?i), ka pono a me ka palekana?

?O Citicoline kahi nucleotide ho?okahi i haku ?ia me ribose, cytosine, pyrophosphate a me choline. He nucleotide endogenous o ke kino kanaka. Ho?opili ia i nā ala metabolic ko?iko?i i loko o ke kino. He mea mua ia o ka phospholipid synthesis o ka neuron cell membrane structure a me kahi precursor o ka biosynthesis o ka neurotransmitter acetylcholine.

?O Citicoline kahi mea neuroprotective hiki ke pale aku i nā neurons nāwaliwali, a laila e hō?emi a pale i ka pi?i ?ana o ka ma?i. I kēia manawa, ?o nā mea neuroprotective ma?amau i ho?ohana ?ia i ka ho?oma?ama?a lapa?au e pili ana i nā blockers channel calcium, glutamate antagonists, free radical scavengers, a me nā cell membrane stabilizers, ma waena o ka citicoline e pili ana i nā stabilizers membrane cell.

CiticolineLoa?a i nā hopena pharmacological multi-target, a ?o kēia mau hana hana e loa?a iā ia ka mana nui i ka neuroprotection a me ka ho?oponopono ?ana i ke a?alolo. Loa?a iā ia ka hopena neuroprotection o ka pale ?ana i ke ?ano o ka hō?eha neuronal a me ka hopena ho?oponopono a?alolo ma hope o ka hiki ?ana o ka hō?eha neuronal, e ho?onui ana i ka puka makani manawa therapeutic o citicoline.

Ma muli o kāna mau waiwai pharmacological, ho?ohana nui ?ia ka citicoline i ka mālama ?ana i ka hahau ?ana, impairment cognitive, traumatic brain injury, Parkinson's disease, glaucoma, diabetic peripheral neuropathy, tinnitus a me nā ma?i ?ē a?e, a ua hō?oia ?ia kona pono a me ka palekana i nā noi?i lapa?au he nui, me nā hō?ike olakino e pili ana i nā hō?ike. ?O ka hahau ?ana: ?o ka hahau ?ana he ?ano o ka cerebral vascular blockage a i ?ole rupture, e hopena i ka pō?ino o ka lolo o kahi papa o nā ma?i, me ka ischemic a me ka hemorrhagic stroke, ?o ia ka ischemic stroke ke ?ano nui o ka hahau ?ana, helu no 75% a 90% o nā hahau āpau. ?O 35%-40.9% ka pilikia o ke ola ?ana o ka hahau ?ana i ko mākou heluna kanaka, ?o ke kūlana mua ma ka honua, ?a?ole ?o ia wale nō, ?o ka hahau ke kumu mua o ka make a me ke kīnā o ko mākou po?e kama?āina.

Nā hō?ike noi?i lā?au lapa?au:

1. I ka makahiki 2002, ua pa?i ka American Journal Stroke i ka meta-analysis o nā ho?okolohua lapa?au i nā ma?i me ka ma?i ischemic stroke, i hō?ike ?ia ua ho?onui ?ia ka citicoline waha i ka hiki ke ho?ōla hou ?ia nā ma?i ma?i ma hope o 3 mau mahina [1].

2. I ka makahiki 2009, ua mālama ?ia kahi ho?okolohua noi?i nānā lā?au lapa?au ma South Korea no 4191 mau ma?i me ka ma?i ischemic acute, a ua hō?ike nā hopena i ka citicoline i ho?omaika?i i ka helu NIHSS a me ka helu BI o nā mea ma?i me nā pōmaika?i i ka wā mua a me ka hopena o ka mālama ?ana, a ?oi aku ka nui o nā pōmaika?i noi lō?ihi, a ua ho?opili maika?i ?ia ka hopena therapeutic me ka dosis. ?Oi aku ka maika?i o ka ho?omaika?i ?ana i ka hui ki?eki?e (≧2000mg / lā), a ua palekana a ?ae ?ia ka noi lō?ihi [2].

3. ?O nā hopena o kahi noi?i pilot multicenter, randomized, double-blind, placebo-controlled pilot study on cerebral hemorrhage e hō?ike ana he lā?au palekana ka citicoline no ka mālama ?ana i ka hemorrhage cerebral me kahi hopena therapeutic maika?i [3].

4. Ua loiloi ?ia kahi ha?awina hāmama, randomized, parallel study i ka hopena o ka citicoline i ka hō?ino ?ana o ka na?au ma hope o ka hahau ?ana, a ua hō?ike nā hopena i ka ho?ohana lō?ihi ?ana i ka citicoline i ho?omaika?i nui ?ia i ka hō?ino cognitive post-stroke [4].