?O ka ?elemakule kahi hana pa?akikī, multi-stage, ka?ina lohi e hana ?ia i loko o ke ola. Me ka holo ?ana o ka manawa, e lohi mālie ana nā ?i?o a me nā ?i?o o ke kino o ke kanaka, a hiki mai kekahi mau ma?i i ka ulu ?ana o ka makahiki, e like me ka ma?i kanesa, ka ma?i diabetes, nā ma?i cardiovascular a pēlā aku.

Ua hō?ike ?ia nā ha?awina hou a?e e hiki ke ho?olō?ihi i ke ola olakino ma o ka anti-oxidation, ka ho?oulu ?ana o ka mitochondrial autophagy a me nā mea hana ?ē a?e, a loa?a iā lākou nā waiwai anti-aging.

Ma mua, ua?ike nā mea noi?i i ka sage extract hiki ke ho?opane?e i ka?elemakule i loko o nā ho?okolohua vitro, a ma ka?iole a me ke kanaka i loko o nā hi?ohi?ona vitro, ua ho?emi nui ka sage extract i ka helu o nā pūnaewele beta-galactose sidese maika?i, e hō?ike ana i nā waiwai kū'ē.

I kēia mau lā, ua pa?i nā mea noi?i ma ke Kulanui o Padova ma Italia i kahi pepa ma ka puke pai Nature Aging i kapa ?ia "Targeting senescence induced by age or chemotherapy with a polyphenol-rich. natural extract improves longevity and healthspan in mice."

Ua hō?ike ?ia nā ha?awina e hiki ke ho?onui i ke ola o ka ?iole i kēlā me kēia lā i ka ?ai ?ana o ka sage, kaohi ?ana i ka mumū o ka makahiki, ka fibrosis a me nā hō?ailona ?elemakule i nā ?ano kiko?ī, a ho?omaika?i i nā phenotypes kahiko.

I loko o kēia noi?i, ua kālailai nā mea noi?i i ka hiki ke kū?ē i ka wā kahiko o ka sage extract (HK) in vivo ma o nā ki?i ?iole, ma ka ho?ohui ?ana i nā ha?aha?a ha?aha?a o HK i ka wai inu i kēlā me kēia lā, a me ka nānā ?ana i ka hō?ili?ili ?ana o nā cell senescent i nā ?iole, a me nā ?āpana pili makahiki, me ka lō?ihi, ke olakino kino, fibrosis, mineralization iwi, a me ka mumū.

Hā?awi ka po?e noi?i i nā ?iole he 20 mau mahina i ka wai inu i loa?a iā HK a hiki i ko lākou make ?ana.

Ua hō?ike ?ia nā hopena he 32.25 mahina ka awelika o ke ola o nā ?iole ma ka hui mālama HK, ?oiai ?o ka awelika o ke ola o nā ?iole i loko o ka pū?ulu ho?omalu he 28 mahina wale nō. Ua ho?olō?ihi ?ia ka lā?au lapa?au HK i ke ola ma 4.25 mau mahina, a ua ho?onui nui ?ia ke ola o nā ?iole wahine a me nā kāne.

?O ka nānā ?ana i ka histopathological o ka ?ili, ka ate, ka pu?upa?a, a me nā māmā o nā ?iole i ?ike ?ia ?a?ole i ho?ololi ka mālama ?ana iā HK i nā ?āpana hematopoietic a i ?ole nā ????mea ?awa?awa o ke kino, e hō?ike ana he palekana ka mālama ?ana iā HK.

Eia kekahi, ua ho?omaika?i ka mālama ?ana iā HK i nā phenotypes kahiko i nā ?iole i ho?ohālikelike ?ia me nā kaohi, me nā ?ano o ka hunchback, ka ulu ?ana o ka tumora, a me ke kūlana hulu holoholona.

Hō?ike kēia mau hopena e hiki ke ho?olō?ihi i ka mālama ?ana iā HK i ke ola olakino a me ka lō?ihi o ke ola ?ana o nā ?iole, a ?a?ole ?ike ?ia ka ?ona.

Ua ?ike hou ?ia ka nānā ?ana ua ho?omaika?i ka lapa?au ?ana iā HK i nā phenotypes kahiko i loko o nā ?i?o like ?ole, me ka ho?omaika?i ?ana i ka lauoho lauoho, iwi, olakino ?i?o, a me ka hana ?ana.

Ua hō?ike ?ia ka loiloi mīkini i ka ho?oponopono ?ana o HK i ka ho?onohonoho ?ana o ka ?elemakule SAUL_SEN_MAYO, ?oiai ?o ka ho?onohonoho ?ana o ka ?elemakule i ho?oponopono ?ia i pili me ka overexpression o ka mumū, ka ho?ōla ?ana o ka immune, a me nā ala e pili ana i ka makahiki, e hō?ike ana ua ho?ololi ?o HK i nā hi?ohi?ona transcriptome e pili ana i ka mumū a me ka ?elemakule. Eia kekahi, ?ike ?ia ka nānā ?ana o nā ?i?o, ka ?ili, nā pu?upa?a, a me nā māmā ua ho?emi ka mālama ?ana iā HK i nā pae o nā hō?ailona ?elemakule ma nā ?āpana like ?ole o ke kino.

Ma waho a?e o ka ?elemakule kūlohelohe, ?ike pū nā mea noi?i hiki i ka mālama ?ana iā HK ke pale aku i ka ?elemakule a me ka cardiotoxicity i ho?okumu ?ia e ka lā?au lapa?au chemotherapy doxorubicin, ?oiai e mālama ana i kāna hopena therapeutic.

?O ka mea hope loa, no ka mea, ?o ka HK he extract i loa?a i nā ?ano mea kanu like ?ole, ua loiloi nā mea noi?i i nā mea kiko?ī e pā?ani ana i ka hana anti-aging, a ua hō?ike nā hopena i kahi mea flavonoid, luteolin (Lut), ka mea ikaika o HK anti-aging, e ho?omaika?i i ka ?elemakule ma ka ho?ololi ?ana i ka pilina ma waena o p16 a me CDK6.

I ka hui pū ?ana, ?ike ?ia ka ha?awina i kahi extract kūlohelohe me nā hopena anti-aging e ho?omaika?i ai i ka ?elemakule a me ka ?i?o, ho?omaika?i i nā hō?ailona pili makahiki e like me ka hulu, humpback, ka hō?ili?ili ?ana o nā hō?ailona o ka ?elemakule a me ka pō?ino DNA i loko o nā ?i?o, a me ka ho?onui nui ?ana i ke ola holoholona.