?O ka SAIB (sucrose isobutyrate acetate) kahi mea ho?ohana multifunctional grade pharmaceutical.
?O SAIB (sucrose isobutyrate acetate) kahi mea ho?ohana multifunctional papa lā?au lapa?au. He wai viscous i ho?omākaukau ?ia e ka esterification ho?omalu o ke kō maoli (sucrose) me ka acetic acid a me ka isobutyric anhydride. He hui ia i hana ?ia e ka distillation a me ka hana ho?oma?ema?e loa. Hiki ke ho?ohana ?ia ma ke ?ano he mea ho?oku?u ho?oku?u pa?a, solvent/carrier a me ka ho?ohana ?ana i ka lā?au lapa?au.
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Nā hi?ohi?ona huahana SAIB
He mea ho?ohehe?e maika?i ?o SAIB no ka API hydrophobic a he hana ho?oku?u lohi.
?A?ole ?o SAIB i crystallize a noho mau i ka amorphous i ka lumi wela, kahi e ho?oikaika nui ai i ka nui o ka lawe ?ana i ka lā?au;
?A?ole polymeric ?o SAIB a ?a?ole ho?ohui a ho?ohehe?e ?ia ke ho?opili ?ia me nā wai kino wai. Hiki ke ho?ohehe?e ?ia ka SAIB i loko o nā mea ho?ohehe?e kūlohelohe a kūpono me nā mea he nui; Hiki ke ho?opuehu ?ia ?o SAIB i ka wai me ke kōkua o nā mea ho?ohehe?e organik.
Loa?a i ka SAIB nā waiwai bioadhesive a hiki ke ho?ohana ?ia no nā noi transdermal, sublingual a me buccal patch.
noi huahana
- Ho?opane?e ka ho?oku?u
Ma ke ki?i ma luna, hiki ke ?ike ?ia he waiwai HLB ko SAIB ma kahi o 5, e hō?ike ana he hydrophobic ia.
- ?A?ole hiki ke ho?ohehe?e ?ia ka wai ho?onā API
?O ka Hydrophobic SAIB he mea ho?ohehe?e / lawe maika?i no ka API me ka ho?ohehe?e wai maika?i ?ole, a ?o ka ho?ohana ?ana iā SAIB e ho?omaika?i i ka solubility o nā lā?au lapa?au ?ole.
- Kāohi i ka ho?ohana lā?au
Ho?onui ka ho?ohana ?ana i ka SAIB i ka nui o nā opioids i ka wā e wili ai a ho?opilikia i ka lawe ?ana i ka lā?au.
(1) ?O nā polymers (polyoxyethylene a / a i ?ole hydroxypropyl methylcellulose) a me ka tocopherol acetate he mau granules i hana ?ia mai kahi wai wai?ona o SAIB. Ho?oka?awale ?ia nā mea ho?omākaukau ma ke ?ano he Uncured / Uncured a i ?ole wela-cured / Cured (ho?ōla ?ia 90oC no 30 mau minuke).
(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene a / a hydroxypropyl methylcellulose) a me ka tocopherol acetate he mau granule i hana ?ia mai kahi wai wai?ona o SAIB. Ho?oka?awale ?ia nā mea ho?omākaukau ma ke ?ano he Uncured / Uncured a i ?ole wela-cured / Cured (ho?ōla ?ia 90oC no 30 mau minuke).
Ua hō?ike ka loiloi ho?omāinoino ihu i ka ho?ohana ?ana o SAIB i ka nui o ka pauka i ka manawa o ka wili ?ana, me ka 47% o ka nui o ka pauda wili ma mua o 1mm.
Ho?ohālikelike ?ia me ka pū?ulu ho?omalu, ua emi ka nui o ka unuhi ?ana o SAIB i ka wai, 0,1% N HCl a me 0,1% N NaOH solvents e 41,3% -42,5%, 24,8% -26,1% a me 37,4% -50,6%. ?O ka ho?ohana ?ana i nā mea ho?ohehe?e organik no ka ?ohi ?ana e ho?opuka i nā koena pa?a i pa?akikī ke hele ma nā ala like ?ole o ka lawelawe ?ana (e la?a, injection, ingestion, snorting, etc.), pale ?ana i ka lā?au lapa?au.
hopena
?O ka ho?ohana ?ana i ka SAIB, me ka ?ole o ka uhi ?ana, hiki ke hui pū ?ia me ka API e ho?olō?ihi i ka ho?oku?u ?ana i ka lā?au a ho?okō i ka ho?oku?u mau.
?O ka SAIB Hydrophobic, hiki ke ho?opuehu ?ia i ka wai me ke kōkua o nā mea ho?ohehe?e organik, hiki ke ho?ohana ?ia me ka hydrophobic a i ?ole hydrophilic apis; Hiki i ka SAIB ke ho?omaika?i i ka ho?ohehe?e ?ia o ka API me ka ho?ohehe?e wai maika?i ?ole a he mea ho?ohehe?e maika?i loa a me ka mea lawe no API me ka ho?ohehe?e wai maika?i ?ole.
?O ka ho?ohana ?ana i ka SAIB e pale i ka ho?ohana ?ana i ka lā?au lapa?au ma o ka ho?onui ?ana i ka nui o ka lā?au i ka wā i lepo ai, ke ke?ake?a ?ana i ka lawe ?ana i ka lā?au, a me ka pa?akikī o ka lawe ?ana i ka lā?au ma nā ala like ?ole o ka ho?okele.
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http://86671.cn/factory-price-saib-sucrose-acetate-isobutyrate-product/