Youdaoplaceholder.

Ho?okumu ?ia ka molecular structure o polyglucose me nā koena glucose i ho?opili ?ia ma ke ?ano like ?ole, a ua hā?awi kēia conformation kūikawā iā ia me nā waiwai rheological kū?oko?a. I loko o ka acidic kaiapuni o ka opu (pH 1.5-3.5), kona molekala kaulahao wikiwiki i ka ekolu-dimensional pūnaewele ho?olālā ma o hydrogen pa?a, a me ka viscosity koke pi?i i 1200 mPa · s (ma kahi o ka palua o ka meli), me ka ho?opane?e maika?i ?ana i ka ?ōpū o ka ?ōpū a hiki i ka 40% a ho?olō?ihi i ka mana?o o ka piha. Ma hope o ke komo ?ana i ka ?ōpū li?ili?i, i ka pi?i ?ana o ka pH i ka 6.0-7.5, ua haki kekahi mau hydrogen a hā?ule ka viscosity i 300-500 mPa·s. ?A?ole ia e keakea nui i ka lawe ?ana i nā mea?ai a ?a?ole ho?i e hui pū me nā ?akika bile e hō?emi i ka helu komo ?ana o ka cholesterol. Ke hō?ea i ke kolonā, ma lalo o ka hana o ka microbial fermentation, e emi hou ka viscosity i lalo o 50 mPa·s, e ho?oku?u ana i nā waikawa momona pōkole (SCFAs) e hā?awi i ka ikehu no nā probiotics (Figure 1).

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Youdaoplaceholder0 Kāko?o ?ikepili ? :

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Ka lō?ihi o ka ho?okahe ?ana o ka ?ōpū: 40% (Food Hydrocolloids 2022, n=30)

Ka nui o ka ho?opa?a ?ana i ka cholesterol: 22% (?ike palapala hō?oia GRAS mai ka US FDA)

Ho?onui ?ia ka hana ?ana o nā SCFA: Ua ho?onui ?ia ka nui o ka waikawa acetic acid i 3.8 mau manawa (Gut 2023, Ho?ohālike holoholona)

Youdaoplaceholder0 1.2 Ho?olālā "Precision hānai" no ka microbiome ?

?A?ole pili wale ka ho?oponopono viscosity o polydextrose i ke ka?ina hana ho?ohehe?e kino, akā hana pū kekahi i kahi pilina ikaika me ka flora intestinal. ?O ke kūlana viscosity ki?eki?e e hana i kahi pale kino i loko o ke kolonā proximal, e hō?emi ana i ka pilina ma waena o nā bacteria pathogenic a me ka mucosa intestinal. I ka emi ?ana o ka viscosity, ho?ololi mālie ia i kahi substrate fermentable, e ho?oulu maika?i i ka ho?onui ?ana o Bifidobacteria a me ka bacteria lactic acid. Ua ?ike ?ia kahi hui mai ke Kulanui o Cambridge ma o ka metagenomic sequencing ?o ka ho?ohana mau ?ana i ka 12g/lā o ka polydextrose no nā pule he 8 hiki ke ho?onui i ka ratio F/B o ka Thick-miliae/Bacteroidetes i 1.3 (me ke kumu olakino o 1.5-2.0), a ho?onui i ka nui o ka butyric acid e like me Fae bacteria (e like me Fae 5 bacteria). ?O kēia hopena pālua ?elua o ka "pale mua, a laila hānai" kūpono i nā pono kaiaola o nā ?āpana like ?ole o ka ?ōpū ?ōpū.

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Youdaoplaceholder0 Mokuna 2 Ka Ho?ololi ?ana i ke ?ano o ka ho?ohana ?ana: ?O ke komo ?ana i nā palena palena mai nā mea?ai i ho?opa?a ?ia i ke kō i ka mea?ai ICU ?

Youdaoplaceholder0 2.1 ?Oihana Mea?ai: ?O ka "iwi ?ike ?ole" o nā huahana GI ha?aha?a ?

Ma ke kahua o ka kuke ?ana, ?o ke ki?eki?e o ka hiki ke pa?a i ka wai (> 8g wai / g) a me ke kūpa?a wela (ka ho?omanawanui i 200 ℃) o ka polyglucose e lilo ia i mea kūpono no ka sucrose. Ho?ohana ?ia ka "Zero Sugar Cookies" e ka Hui Meiji o Iapana i ka polyglucose ma ke ?ano he fiber kumu, e loa?a ana he 1.2g wale nō o nā ?akika ?upena no kēlā me kēia kuki, a ?a?ole ?oko?a ke ?ano a me ke ?ano o nā huahana i loa?a i ke kō. ?O ka mea nui a?e, hiki i kāna ho?oponopono viscosity i loko o ka ?ōpū li?ili?i ke ho?opane?e i ka absorption glucose a hō?emi i ke ki?eki?e o ka glucose koko postprandial e 34% (Clinical data from Diabetes Care 2021).

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Youdaoplaceholder0 Ka hihia hou ? :

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Youdaoplaceholder0 Nestle ? : ?O ka "Smart slow-release energy bar" i ho?omohala ?ia e ka hui ?ana i ka polydextrose me ka dextrin kūpa?a e hō?ike ana i kahi ho?olālā gradient viscosity e ho?olō?ihi i ka ho?ohana ?ana i ka carbohydrate i 6 mau hola, e ho?okō ana i nā pono lako ikehu mau o nā mea holo marathon.

Youdaoplaceholder0 Nongfu Spring ? : Ho?oku?u ?ia ?o "Intestinal Vitality Sparkling Water" me ka polyglucose i ho?ohui ?ia, e ho?ohana ana i kāna waiwai fermentation ha?aha?a ha?aha?a e hana i kahi kinoea māmā i loko o ke kolone e ho?oulu ai i ka peristalsis ?ōpū. Ua kū?ai aku ma luna o 100 miliona mau hue i loko o ?ekolu mahina.

Youdaoplaceholder0 2.2 ?O ka mea?ai lā?au lapa?au: ?O ka "intestinal barrier Guard" no nā ma?i ma?i ICU

?O ka hemahema o ka ?ōpū mucosal i nā ma?i ma?i ko?iko?i ke alaka?i pinepine nei i nā ma?i systemic. Ua hō?ike ?ia kahi ho?ā?o ho?okele randomized (n=158) i alaka?i ?ia e ka Halemai Ho?ohui Mua o Zhejiang University i nā po?e ma?i ICU i ho?ohui ?ia me 15g o polyglucose i kēlā me kēia lā he 42% ka emi ?ana o ka endotoxemia a he 29% ka emi ?ana o ka intestinal permeability index (plasma ligonin). Aia ka mīkini i loko o ke kūlana ki?eki?e-viscosity e hana i kahi ki?i?oni?oni pale i loko o ka ?ōpū, e hō?emi ana i ka pilikia o nā ma?i ?eha. ?O ka waikawa butyric i ho?oku?u ?ia e ka ?āpana colonic e paipai pololei i ka mānoanoa o ka papa mucus (e ho?onui ana i ka nui o nā cell goblet e 37%), e ho?okō i ka ho?oikaika ?ana i ke kino a me ke kemika pālua.

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Youdaoplaceholder0 Mokuna 3 ?Ike ?enehana: ?O ka ho?omaika?i ?ana mai ka 'Empirical Formulas' i ka' Computational Nutrition '?

Youdaoplaceholder0 3.1 Ho?oponopono pololei o ka ho?ololi molekala ?

Ua kaupalena ?ia ka laulā pane viscosity o ka polydextrose ku?una, he mea pa?akikī ke ho?ohālikelike pono i nā koi pilikino. I Iune 2023, ua ho?olaha ?o DSM o Netherlands i kāna ?enehana patented "PolySmart?", nāna i ho?omohala i ?ekolu mau ?ano ?ano viscosity curve ma ke kāohi ?ana i ke degere o ka polymerization (waiwai DP) o ka glucose a me ka sorbitol.

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Youdaoplaceholder0 G type ? (ho?onui ?ana i ka ?ōpū): ?O ka viscosity a hiki i 1500 mPa·s ma ka pH

Youdaoplaceholder0 C type ? (colon-targeted): E hā?ule koke ka viscosity i 30 mPa·s ma ka pH > 6.5, makemake ?ia no ka po?e me ka constipation;

Youdaoplaceholder0 Type B ? (ke ?ano kaulike): ?O ka ho?ololi ma?alahi o ka viscosity o ka ?ōpū holo?oko?a, kūpono no ka ho?okele glucose koko i nā ma?i ma?i ma?i.

Youdaoplaceholder0 3.2 Ho?olālā ho?olālā kōkua kōkua AI ?

?O ke kahua "FiberEngine" i ho?omohala ?ia e ka hui ?Isera?ela ?o NutriAI e ho?ohui i ka 2 miliona gut microbiota data a me nā hi?ohi?ona dynamics fluid, hiki ke wānana i ka nui o ka ho?ohui ?ana o ka polydextrose ma lalo o nā makahiki like ?ole a me nā kūlana ma?i. No ka la?ana, no nā po?e ma?i me IBS (Irritable Bowel Syndrome), ?ōlelo ka ?ōnaehana i ka hui ?ana i kēlā me kēia lā o 8-10g o polyglucose a me 2g o fructooligosaccharides, e hō?emi ana i ka ulu ?ana o ka ?ōpū o ka ?ōpū e 65% (2023 user tracking data).

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Youdaoplaceholder0 Mokuna 4 ?Oihana Huhū: ?O ka "Fiber Blue Ocean" a Giants e ho?okūkū nei no ?

Youdaoplaceholder0 4.1 Pumehana ka heihei hiki ?

Kuhi ?ia ka nui o ka mākeke polydextrose honua e ulu mai 870 miliona US kālā ma 2023 a i 2.1 biliona US kālā ma 2030 (CAGR 12.3%). Ua lilo ?o Kina i kahua kaua nui.

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Youdaoplaceholder0 Baolingbao Bio ? : Ho?olilo i 500 miliona yuan e ho?onui i 30,000 tons i kēlā me kēia makahiki hana laina, me ka ho?ohana ?ana i ka hana enzymatic synthesis e ho?okō ai i ka 99.5% ma?ema?e;

Youdaoplaceholder0 Rogate ? : Ho?okumu ?ia nā microcapsules probiotic-polyglucose me ka hui pū ?ana me CHR. Ua ho?onui ?o Hansen i ka nui o ke ola a hiki i ka 90%;

Youdaoplaceholder0 Matsuya Chemie, Iapana ? : Ho?okomo ?ia ?o "nano-fibrotic polyglucose," ?ekolu mau manawa o ka viscosity regulation sensitivity a ua hā?awi ?ia i ka inoa lā?au keiki makua ?ole e ka FDA no ka ma?i pōkole pōkole.

Youdaoplaceholder0 4.2 ?Elua mau pilikia o ka ho?oponopono a me ka ?ike ?

?Oiai ua ?ae ?ia ka polydextrose ma ke ?ano he fiber mea?ai e ka European Union, Kina a me nā ?āina ?ē a?e, aia nō ka po?e kū?ai i nā kuhi hewa. Hō?ike ?ia kahi noi?i a FMCG ma ?Amelika Hui Pū ?Ia he 28% wale nō o nā mea kū?ai aku hiki ke ho?oka?awale pololei i nā ?oko?a hana ma waena o ka polydextrose a me ka starch kūpa?a. ?Oi aku ka ko?iko?i, hiki i ka ?ai nui ?ana (> 50g/lā) ke ho?oulu i ka ?ōpū o ka ?ōpū a i ?ole ke ke?ake?a i ka absorption mineral. Pono koke ka ?oihana e ho?okumu i nā alaka?i ho?ohālikelike.

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Youdaoplaceholder0 Mokuna 5 Ke nānā nei i mua: ?O ka "Fiber Network" mai GUT a i ke Ola kino ?

Youdaoplaceholder0 5.1 Hō?ike hou no ka ho?oponopono ?ana i ka axis lolo-gut ?

I ka ho?omaka ?ana o 2024, ua ?ike ka California Institute of Technology i nā ho?okolohua ?iole e hiki i ka butyric acid i hana ?ia e ka fermentation o polydextrose ke ho?oulu i nā neurons hypothalamic ma o ke a?alolo vagus, e hō?emi ana i nā ?ano hopohopo e 43%. Hā?awi kēia i ka wehewehe molecular-level no ka ?ōlelo ?ana "?o ka mea?ai ki?eki?e-fiber e ho?omaika?i i ke olakino no?ono?o".

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Youdaoplaceholder0 5.2 Nā mea hou e ho?opilikia i ka biology Synthetic ?

Ua ho?ohana ka US ho?omaka Zymergen i ka ?enehana CRISPR e ho?ololi iā Trichia pastoris, hiki iā ia ke hūnā pololei i ka "gene-edited polyglucose" me kahi curve viscosity ma?amau. Ua hō?ike kēia huahana i ka ho?omaika?i ?ana o 80% i ka pololei o ka pane ?ana o ka pH i nā ho?okolohua simulated digestion a mana?o ?ia e komo i ke kahua ho?okolohua lapa?au ma 2025.

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Youdaoplaceholder0 Mana?o: Ho?ololi hou i nā "palena na?auao" o Fiber ?

?O ka hopena gradient viscosity o ka polydextrose e hō?ailona ai i kahi au hou no ka fiber dietary, e ne?e ana mai ka "passive supplementation" i ka "active regulation". Inā hiki i kahi mea fiber ke ho?oponopono kū?oko?a i kāna hana ma ka pane ?ana i ke kaiapuni digestive, ke ?ike nei paha mākou i ka ne?e ?ana o ka paradigm i ka ?epekema mea?ai - ?a?ole ?o nā hana olakino e hiki mai ana ka hana ho?okahi o ka mole ho?okahi, akā he hulahula hui o nā mea akamai, ka microbiome, a me ka na?auao. E like me ka Nobel Prize winner in Chemistry, Frances Arnold, i kekahi manawa i ?ōlelo ai, "Ua pa?a nā molekala i loko o ke ?ano i nā mea hiki ?ole ke hana.