1. Nā pōmaika?i o nā hi?ohi?ona metabolic a me ka ho?okele glucose koko

1. ?A?ohe calorie a ?a?ohe koena metabolic
Ma hope o ka ho?ololi ?ia ?ana o ka molecular structure o ka sucralose e ka chlorination, ?a?ole hiki i ka ?ōnaehana ho?ohehe?e kanaka ke ho?ohehe?e iā ia i nā kō. Hō?ike ka ?ikepili ma?i ma kahi o 85% e ho?oku?u pololei ?ia ma o ka ?ōpū ma hope o ka ?ai ?ana, a ?o ke koena 15% e ho?ololi ?ia e ke ake i loko o nā mea ?awa?awa ?ole a ho?oku?u ?ia i loko o ka mimi ?13. Ho?olilo kēia waiwai i mea ?ono "zero calorie" ?oia?i?o, me ke kaumaha ?ole o ka ikehu no ka po?e ma?i ma?i ma?i i kēlā me kēia lā a hiki i 9mg/kg paona kino ?28.

2. ?O ka mīkini pa?a glucose koko
? ?a?ohe ho?oulu ?ana i ka insulin ?: Ua hō?ike ?ia kahi noi?i 2024 e ka International Diabetes Federation (IDF) ?a?ole i ho?āla ?ia ka sucralose i ka mea ?ono momona T1R2/T1R3 i loko o nā cell beta pancreatic a ?a?ole ia i ho?omaka i ka huna ?ana o ka insulin ?57.
??alo i ka lawe ?ana i ka glucose ? : ?A?ole e like me ka sucrose, ?a?ole ke?ake?a ka sucralose i ka hana o ka transporter glucose SGLT1 i loko o ka ?ōpū li?ili?i, a mālama ?ia ka maika?i o ka absorption glucose intestinal ma kahi pae ma?amau ?36. No ka la?ana, he 50 po?e me ka ma?i ma?i type 2 i ?ai i nā mea inu i loko o ka sucralose no 30 mau lā i ka li?ili?i ma mua o 0.3% fluctuation i kā lākou pae o A1c (HbA1c) 5.
?O ka lua, ka waiwai kūpono o ka mālama ?ana i nā mea?ai

1. Hiki ke ho?ololi i nā kō ku?una
?O ka ?ono o ka sucralose he 600 mau manawa ma mua o ka sucrose, a he mea li?ili?i wale nō e hiki ke ho?okō i nā pono ?ono. ?o kahi la?ana:

?O ka ho?ohui ?ana i ka 30mg sucralose i ka 300ml wai inu ?ole hiki ke loa?a ka ?ono e like me 10% sucrose solution ?16;
?O ka ho?ohui ?ana i 15mg no kēlā me kēia 100g o ka palaoa i loko o nā mea?ai i ho?omo?a ?ia e hō?emi i ka ?ai ?ana o ka sucrose ma kahi o 45g ?48.

2. Ka hopena o ka ho?olālā ?ai mea?ai
? E hō?emi i ka hilina?i carbohydrate ? : Ma ka ho?ololi ?ana i nā ha?aha?a ku?una, hiki i ka ma?i ma?i ke ho?emi i ka ?ai ?ana i kēlā me kēia lā o nā carbohydrates e 50-80g, e like me ka ?oki ?ana i 200-320kcal calories ?27;
? Ho?omaika?i i ka ?oko?a mea?ai ? : Ho?onui ?ia ka ?ae ?ia o nā mea?ai diabetes ma mua o 40% ma o ka ?ae ?ana i ka ?ai ?ana i nā mea?ai momona ki?eki?e e like me ka ice cream a me ka keke 38.
?O ke kolu, ?o ka hopena pale ?ana i nā pilikia olakino

1. Kāohi i nā pilikia ma?i diabetes
? Ho?emi i ka pilikia o ka ma?i niho ? : ?A?ole hiki i ka bacteria waha ke wāwahi i ka sucralose, a ?o kāna mau waiwai anti-caries i ho?emi i ka nui o ka ma?i waha e 27% i ka po?e me ka ma?i diabetes ?46;
? Ka pale ?ana i ka ?ōnaehana cardiovascular ? : Ma hope o ka ho?ololi ?ana i ka sucrose, ua ho?emi ?ia nā pae triglyceride o nā mea ma?i ma ka awelika o 0.4mmol/L a ua emi iho ka lipoprotein ha?aha?a ha?aha?a (LDL) e 12%?78.

2. Hiki ke ho?ololi i nā hi?ohi?ona kūikawā
? ?o ke kūpa?a wela ki?eki?e ? : i ka wā e kuke ai ma lalo o 120 ℃, ?a?ole e ho?opuka ka sucralose i nā huahana ?ona e like me ka chloropropanol, i kūpono no ka hana ?ana i nā pāpa?i ha?aha?a ha?aha?a ?38;
? Ka pili o ka lā?au ? : ?a?ohe pilina me nā lā?au hypoglycemic ma?amau e like me ka metformin a me ka insulin, akā pono e lawe pū ?ia me nā lā?au anticoagulant e like me warfarin ?27 i ka manawa 2 hola.
?O ka hā, nā pono no?ono?o a me ka pilikanaka

1. Ho?omaika?i i ka maika?i o ke ola
?O ka po?e ma?i me ka ma?i ma?i ma?i he 62% ka emi ?ana o ke kaumaha no?ono?o ma muli o ka nele o ka momona a me ka awelika he 3.2 helu hō?emi i ka helu Depression Scale (PHQ-9) 68. Ua hō?ike ?ia ka noi?i ?o Consumer 2024 ua ho?onui ?ia ka ?olu?olu o ka mea?ai ma waena o ka po?e ma?i ma?i i ho?ohana i ka sucralose ma ke ?ano he pani kōpa?a mai 43% a i 79%?3.

2. Ho?onui i ke kumukū?ai waiwai
? hō?emi kālā ho?olimalima ? : hiki ke hō?emi i ke kumukū?ai o ka mālama ?ana i ka wāwae ma?i ma?i, retinopathy a me nā pilikia ?ē a?e ma kahi o 3200 yuan/kanaka ?78;
? ?oihana mea?ai mea hou ? : E ho?olaha i ka mākeke mea?ai me ke kō ?ole e ulu e 18% i kēlā me kēia makahiki a ke mana?o ?ia e hiki i 120 biliona yuan ?14 i 2025.

5. Nā kiko?ī noi?i a me nā mea e hiki mai ana

1. Nā loina o ka ho?ohana ?epekema
? Dose control ? : E hahai i ka WHO i ?ōlelo ?ia i ka palena ki?eki?e o 9mg/kg ke kaumaha o ke kino i kēlā me kēia lā (ma kahi o 540mg no 60kg mau mākua) ?28;
? ke koho ka?ina ? : ?oi aku ka maika?i o nā huahana ?enehana microencapsulation e hō?emi i ka hopena i ka flora intestinal (ua ho?emi ?ia ka nui o ka hana bifidobacterium mai 30% a i 8%) ?18.

2. Ke alaka?i ho?omohala ?enehana
? ?enehana ho?oponopono pololei ? : ?O ke ka?ina hana "directed chlorination" i ho?omohala ?ia e Jinhe Industry ma 2025 e hō?emi i ke koena o ka chloropropanol i 0.01ppm?8;
? Noi?i lapa?au e pili ana i nā hō?ike ? : Ho?omaka ka International Diabetes Association i ka noi?i cohort 100,000-kanaka e loiloi i nā hopena lō?ihi o ka sucralose ma ka hana mokupuni ?56.
hopena
Hā?awi ?o Sucralose i nā ma?i ma?i diabetes me kahi hopena e kaulike ai i nā pono ?ono me ka ho?okele olakino. Ho?okomo ?ia kāna mau kumu waiwai i ka metabolic inertia, ka pa?a o ka glucose koko a me ka pale ?ana i ka ho?opi?i. Me nā ka?ina hana i ho?omaika?i ?ia (e like me ka ?enehana microencapsulation) a me nā ?ōnaehana ho?oponopono i ho?omaika?i ?ia (e like me ka ho?oponopono hou ?ana o Kina's Nutrition Labelling Guidelines for Pre-Packaged Foods in 2025), e lilo ka sucralose i mea palekana a ?oi aku ka maika?i no ka mālama ?ana i ka mea?ai diabetes. Eia nō na?e, pono e ho?oikaika ?ia ?a?ole hiki ke ho?ololi i ke kō i ke kūlana ko?iko?i o ka mea?ai kaulike a me ka ho?oma?ama?a ho?oikaika kino, a pono e ho?ohana ?ia ka ho?ohana ?epekema ma luna o ke alaka?i olakino pilikino ?