?O ka Vitamin B3, ka mea i kapa ?ia ?o niacin, he huaola hiki ke ho?ohehe?e ?ia i ka wai e hana i nā ?ano hana physiological ko?iko?i i loko o ke kino. Ua hō?ike ?ia nā ha?awina mua e komo ana ka huaora B3 i ke ka?ina hana o ka ikehu o ke kino, ho?oikaika i ka metabolism o nā ?ili ?ili, a loa?a pū kekahi hopena antioxidant.

Non-alcoholic fatty ate ma?i (NAFLD), ?o ia ka mea ki?eki?e loa o ka ma?i ate ma?i ma?i ma Kina, aia ma mua o 150 miliona mau ma?i ma Kina, a ?o 10-20% e ulu hou i loko o ka steatohepatitis non-alcoholic (NASH), i hō?ike nui ?ia e ka mumū a me ka pō?ino o ke akepa?a, pinepine pū ?ia me ka fibrosis. Holo wikiwiki ?o NASH a ?oi aku ka nui o ka loa?a ?ana o nā ma?i ate ko?iko?i e like me ka cirrhosis a me ka ma?i ma?i ate.

I kēia mau lā, ua ho?opuka nā mea noi?i mai ke kula o ke ola olakino ma ke Kulanui o Sun Yat-sen i kahi pepa ma ka puke pai JAMA Network Open i kapa ?ia ?o "Dietary Niacin Intake and Mortality Among Individuals With Nonalcoholic. Fatty Liver Disease "pepa noi?i.

Ua hō?ike ?ia ka ha?awina ?o ka ho?ohui ?ana me ka huaora B3, a i ?ole ka hō?emi ?ana i ka hopena o ka make i nā mea ma?i me ka ma?i ?a?ai momona ?ole, ua pili pū me ka ho?emi ?ana o 30% i ka make o nā kumu āpau i nā po?e komo me ka ?ai ki?eki?e loa (≥26.7mg / lā) i ho?ohālikelike ?ia me nā po?e me ka ha?aha?a ha?aha?a (≤18.4mg / lā).

Ma kēia noi?i, ua kālailai nā mea noi?i i ka pilina ma waena o ka lawe ?ana i ka huaora B3 mea?ai a me ka hopena o ka make ?ana o nā kumu āpau i nā ma?i me ka ma?i awelika momona ?ole ma o ka hō?ili?ili ?ana i ka mea?ai huaora B3 mai ka National Health and Nutrition Examination Survey (NHANES) database o 4,315 NAFLD ma?i me ka awelika makahiki o 53 makahiki.

Ua māhele ?ia nā mea komo i ?ekolu mau pū?ulu e pili ana i ka lawe ?ana i ka vitamina B3: pū?ulu ha?aha?a ha?aha?a (≤18.4mg / lā), pū?ulu ?ai waena (18.5-26.6mg / lā) a me ka hui lawe ki?eki?e (≥26.7mg / lā).
I loko o kahi manawa hahai o 8.8 mau makahiki, he 566 ka nui o nā make i ho?opa?a ?ia, 197 o ia mau mea i pili i ka ma?i cardiovascular.

Ua ?ike ?ia ka hō?ike ?ana ua loa?a i nā po?e komo me ka ?ai ki?eki?e loa he 30 pakeneka ha?aha?a ha?aha?a o ka make a pau i ho?ohālikelike ?ia i nā po?e me ka ha?aha?a ha?aha?a.

Eia kekahi, ?o ka po?e i komo me ka ?ai ki?eki?e loa he 35 ka nui o ka emi ?ana o ka make ?ana o ka ma?i cardiovascular, akā ?a?ole ia he mea nui.

Ua ?ike hou ?ia ka ?ike ?ana i kahi pilina ko?iko?i ma waena o ka lawe ?ana i ka huaora B3 a me ka pilikia o ka ma?i ma?i a me nā kumu āpau, me ka emi ?ana o ka make i nā ma?i ma?i ma?i ?ole i ho?ohālikelike ?ia me ka po?e me ka ma?i diabetes.

Wahi a ka po?e noi?i, ?o niacin kekahi o nā precursors o NAD synthesis a ua lilo i mea ko?iko?i no ka pale ?ana a me ka mālama ?ana i ka ma?i ate. Ua hō?ike pū ?ia nā ha?awina ho?opili kanaka e hiki i ka niacin ke ho?omaika?i i ka momona momona a ho?emi i ka momona o ka ate. Ma nā ha?awina preclinical, ua ?ike ?ia ka niacin e kāohi a ho?ohuli i ka steatosis a me ka mumū, a pale i ka fibrosis. Loa?a kēia mau hopena ma ka hō?emi ?ana i ke ko?iko?i oxidative, kaohi ?ana i ka diacylglyceryl acyltransferase 2 a me ka hana NADPH oxidase, a me nā hana ?ē a?e.

He mea pono e ha?i ?ia ma Kepakemapa 2023, ua pa?i nā mea noi?i mai ke Kula o ka Public Health ma Sun Yat-sen University i kahi pepa i loko o ka puke pai Nutrients i kapa ?ia "Association between Dietary Niacin Intake and Nonalcoholic Fatty Liver Disease: NHANES 2003-2018 "pepa noi?i.

Ua hō?ike ?ia ka ha?awina e pili ana ka ho?ohui ?ana i ka vitamina B3 me ka ha?aha?a ha?aha?a o ka ma?i momona momona ?ole, me ka po?e me ka nui o ka niacin intake (≥29.2mg / lā) he 31% ha?aha?a ha?aha?a o ka ma?i ?a?ai momona ?ole i ho?ohālikelike ?ia me ka po?e me ka ha?aha?a ha?aha?a niacin intake (≤16.3mg / lā).

Ho?ohui pū ?ia, hō?ike ?ia nā hopena e pili ana ka ho?ohui ?ana i ka vitamina B3 me ka ha?aha?a ha?aha?a o ka ma?i momona momona ?ole a me ka hō?emi ?ia o ka make ?ana o nā kumu āpau i nā ma?i me ka ma?i ?a?ai momona ?ole. Pono nā noi?i hou a?e e hō?oia i ka hopena maika?i loa o ka hua?a B3 e hō?emi i ka hopena o ka make āpau i nā ma?i me NAFLD.