?O ka ma?i ?āpa?a wai?ona (ALD), ?o ia ka ma?i ate i ho?okumu ?ia e ka inu nui ?ana i ka wā lō?ihi, ?o ia kekahi o nā ma?i ate ma?amau ma Kina, ?o ia ho?i ka ma?i ?awa?awa momona, ka ma?i hepatitis alcoholic, fibrosis ate alcoholic a me ka cirrhosis alcoholic. I nā makahiki i hala iho nei, ua hō?ike ?ia ka ma?i ma?i o ka ma?i ?awa?awa i ka ulu ?ana ma Kina.

Ma Iulai 2, 2024, Liu Zhihua o Tsinghua University, Wang Hua o Anhui Medical University, Yin Shi o ke Kulanui o Science a me Technology o Kina a me nā mea noi?i ?ē a?e i ho?opuka i kahi ?atikala i kapa ?ia ?o "Dietary fiber alleviates alcoholic liver injury via" ma ka puke pai Cell Host & Microbe "Bacteroides acidifaciens and subsequent ammonia de".

Ua ?ike ?ia kahi mea?ai momona i ka fiber mea?ai hiki ke ho?onui i ka nui o ka B. accidifaciens a ho?emi i ka hō?eha ?ana o ka ?iole i ka ?iole.

Ma ka mīkini, ho?oponopono ?o B.accifaciens i ka metabolism bile acid ma o ka bile saline hydrolysis enzyme (BSH). ?O ka ho?onui ?ana o ka waika bile unbinding e ho?āla i ke ala FXR-FGF15 i loko o ka ?ōpū, pale i ka hana o ka ?ōpū, ho?oikaika i ka hō?ike o ornithine aminotransferase (OAT) i nā hepatocytes, a pēlā e ho?oikaika ai i ka metabolism o ka ornithine i hō?ili?ili ?ia i loko o ke ake i ka glutamate. Hā?awi i nā mea maka no ka ho?oma?ema?e ?ana i ke akepa?a a ho?emi i ka pō?ino o ke akepa?a.

Ma kēia noi?i ?ana, ua ho?okomo mua nā mea noi?i i ka ma?i ate ?ona i loko o ke ?ano ?iole a nānā i nā hopena o ka fiber dietary i ka ma?i ate ?ona i nā ?iole ma o ka ho?ohui ?ana i ka fiber soluble a me ka hiki ?ole.

Ua ?ike ?ia nā hopena i ho?omaika?i maika?i ?ia ka ho?ohui ?ana i ka mea?ai mea?ai i ka ma?i ?a?a i ka ?iole, me ka ho?oha?aha?a ?ana i ka steatosis ate a me ka hō?emi ?ana i ka pākēneka a me ka nui o nā neutrophils ate, ?oiai ?a?ole i loa?a kahi hopena ko?iko?i ka fiber dietary insoluble.

No ka mea hiki i ka fiber mea?ai ke ho?opilikia nui i ka microbiota gut, ua loiloi hou nā mea noi?i inā pili ka ho?omaika?i ?ana i ka ma?i ate ?ona i ka microbiota gut ma o nā ?enehana transplantation microbiota.

Ma hope o ka ho?ololi ?ana, ua ?ike ?ia ?o ka ho?ololi ?ana i ka microflora o nā ?iole i hānai ?ia i ka fiber dietary soluble i ho?emi i ka pae serum alanine aminotransferase (ALT) a me aspartate aminotransferase (AST), ?oiai e hō?emi ana i ka steatosis ate a me nā pae ?ona, e hō?ike ana e hiki ke ho?ololi i ka ho?omohala ?ana o ka ALD ma o ka ho?ololi ?ana i ke ?ano o ka microflora intestinal.

Ua hō?ike ?ia ka ha?awina i ho?omaika?i ?ia ka fiber dietary soluble ate necrosis, ate steatosis a me ka mumū i ke ?ano o ka ?iole o ka ma?i ?awa?awa ?awa?awa, a ua ho?emi ?ia ho?i ke ki?eki?e o ka amonia koko a me ke ko?iko?i oxidative, e hō?ike ana i ka hana ko?iko?i o ka soluble dietary fiber i ka pale ?ana a me ka mālama ?ana i ka ma?i ate ?ona.

He mea nui e ho?omaopopo i ka ?ōlelo ?ia ?ana o nā pākeke e ?ai i ka 25-30 grams a ?oi a?e paha o ka fiber mea?ai i kēlā me kēia lā, akā ?a?ole ho?okō ka hapa nui o nā kānaka i nā ?ōlelo a?oa?o mea?ai. ?O nā kī?aha holo?oko?a, nā hua?ai a me nā mea kanu nā kumu waiwai o ka fiber mea?ai a hiki ke hā?awi i nā micronutrients pono.

I ka hō?ulu?ulu mana?o, hō?ike nā hualoa?a e hiki i ka mea?ai waiwai i ka soluble dietary fiber ke ho?omaika?i i ka hō?eha ?ana i ka ate i ho?okomo ?ia i ka wai?ona i nā ?ano ?iole ?oiai e pale ana i ka pono o ka pale ?ōpū. Loa?a i kēia ha?awina kekahi waiwai lapa?au a me ke ko?iko?i pilikanaka.

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