?A?ole komo ?o Sucralose i ka metabolism i loko o ke kino o ke kanaka a ?a?ole i komo ?ia e ke kino kanaka. Me ka waiwai calorific ?ole, ?o ka sucralose kahi mea momona maika?i loa no ka ma?i ma?i. Ua ho?opa?a ?ia a hō?oia ?ia e FDA i ka makahiki 1998. Hiki ke ho?ohana ?ia ma ke ?ano he mea ?ono honua no nā mea?ai a pau, a ?a?ole pili i ka ne?e ?ana o ka glucose i ke koko. Hiki ke ?ae ?ia e nā po?e ma?i me ka ma?i diabetes. Eia kekahi, ?a?ole ho?ohana ?ia ka sucralose e nā bacteria caries niho a hiki ke hō?emi i ka nui o ka waikawa i hana ?ia e ka bacteria waha a me ka ho?opili ?ana o nā cell streptococcal i ka ?ili o nā niho, e pā?ani pono ana i kahi hana anti caries. Ua hō?ike ?ia nā ha?awina holoholona he palekana ka sucralose no ka ho?ohana lō?ihi ?ana i nā koina he mau haneli mau manawa ki?eki?e ma mua o nā pae ho?ohana kanaka. ?O nā ho?okolohua lō?ihi i hana ?ia ma luna o nā mea manawale?a kanaka ma?amau ua hō?ike ?ia ?a?ole loa?a ka sucralose i nā hopena hiki ?ole i ke olakino kanaka. Ma hope o ka ho'ā?o hō?oia palekana no ka wā lō?ihi, ua hō?oia ka US FDA he mea ho?ohui GRAS (palekana).

Ua ho?ohana nui ?ia ?o Sucralose ma luna o 400 mau ?ano mea?ai, e komo pū me nā mea inu kalapona, nā mea inu kalapona, nā mea inu ?awa?awa, nā hua?ai a me nā mea kanu, nā mea?ai a me nā mea?ai, nā jams, nā mea?ai bakena, ice cream, nā huahana dairy, cereals ?aina kakahiaka, a me nā mea ?ono i kēlā me kēia lā. ?O nā mea inu calorie ha?aha?a ka mākeke nui loa no nā mea ?ono kūlohelohe, me 87 miliona mau mea kū?ai aku ma United States wale nō. Ua ho?olauna ?o Coca Cola a me PepsiCo i nā mea inu ha?aha?a ha?aha?a me ka ho?ohana ?ana i ka sucralose ma ke ?ano he mea ?ono, ?o ia ke kumu o ka ho?olaha mākeke e hiki mai ana. E ho?onui nui kēia i ka noi no ka sucralose ma ka mākeke.