?O ka ma?i ma?i prostate (PC), kekahi o nā ma?i ma?i ma?amau i nā kāne, ua like ia me ka mea pepehi ha?aha?a, me ka hapa nui o nā ma?i e ?ike ana i nā hō?ailona lohi o ka ma?i e hiki ai ke lilo i ka ma?i ma?i weliweli. I kēlā manawa, hiki i ka ma?i prostate ke lilo i mea pa?akikī a ?a?ole i pane mai nā koho lapa?au āpau.

E like me ka ?ōlelo ?ana, pili ka mālama ?ana i "?ekolu wahi o ka lā?au lapa?au, ?ehiku mau wahi mālama", ?o kēia "mālama" i ka hapa nui o ka manawa e pili ana i ka tonic mea?ai. ?O ka ma?i prostate he ma?i holomua lō?ihi. Inā hiki ke ho?ohana ?ia nā ?ano hana kūpono, e like me ka nohona kūpono a me ka ?ai, i ka wā mua o ka ma?i, hiki ke ho?opane?e maika?i i ka pi?i ?ana o ka ma?i prostate a ho?omaika?i i ka wānana o nā ma?i.

Ma ?Okakopa 25, 2024, ua pa?i ?ia ka hui o Polofesa Lloyd Trotman o Cold Spring Harbour Laboratory i loko o ka puke mo?olelo ho?ona?auao honua ki?eki?e ?o Science i kapa ?ia: Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function Research pepa.

Ua ?ike nā ha?awina e hiki ke ho?olō?ihi i ka holomua o ka ma?i ma?i prostate i kahi ho?ohui pro-oxidant, menadione (vitamin K3). ?O ka Menadione kahi wai-soluble precursor o ka huaora K, ka mea ma?amau i loa?a i nā lau lau ?ōma?oma?o, a ?o kāna hana physiological ka mea nui e hāpai i ke koko koko a komo i ka metabolism iwi.

Ua hō?ike ?ia nā ha?awina ?enehana ?o VPS34 kahi pahuhopu nui o ka phosphatidylinositol 3-kinase (PI3K), hiki i ka menadione ke kāohi i ka hana o VPS34, ho?emi i ka hana ?ana o PI3P, a ho?onui i ke ko?iko?i oxidative e alaka?i ana i ka make o nā ma?i ma?i prostate. ?O ka ho?ohālikelike ?ana, ulu mālie nā cell ma?amau a no laila ua lawa ka mālama ?ana i ka ikehu e kū i kēia pō?ino. Eia hou, ua hō?ike ka hui noi?i he hopena lapa?au ka menadione i kahi ma?i ma?i make i kapa ?ia ?o X-linked myotubulin myopathy (XLMTM).

Hō?ike kēia mau ?ike i kahi ala ma?alahi akā maika?i e komo ai i ka ma?i kanesa a loa?a nā hopena hou no ka mālama ?ana i nā ma?i genetic ?ē a?e i ho?okumu ?ia e ka dysregulation o ka hana kinase.

Ua mālama ka hui i nā hi?ohi?ona ?iole RapidCaP me kahi mea ho?ohui pro-oxidant, menadione sodium sulfite (MSB), he mea ho?ohui i mea mua o ka mammalian i ka vitamina K. Ua ?ike lākou he mea hiki ke ho?onui i ka MSB i kēlā me kēia lā i ka wai inu ke kāohi i ka pi?i ?ana o ka ma?i prostate a ho?opuka i kahi hopena pa?a mau.

?O ka holo?oko?a, ?o ke a?o ?ana, i pa?i ?ia ma Science, hō?ike i ka ho?ohui ?ana i nā mea ho?ohui pro-oxidant i ka mea?ai e ho?ohui i ka MSB hiki ke ho?opane?e maika?i i ka pi?i ?ana o ka ma?i o ka ma?i prostate. ?O kēia no ka mea hiki i ka MSB ke kāohi i ka hana o PI3K kinase VPS34, ho?emi i ka hana ?ana o PI3P, a ho?onui i ke ko?iko?i oxidative, e alaka?i ana i ka make o nā ma?i ma?i prostate. Eia kekahi, i ka X-linked myotubular myopathy (XLMTM), hiki i ka MSB ke kāohi i ka hana kinase o VPS34, e ho?iho?i i ka PI3P i nā pae e hiki ke ho?omaika?i i ka ho?omohala ?ana i ka ?i?o.