?O Sucralose kahi pani kō. He mea ?ono i ho?ohana nui ?ia. Pili pinepine ka po?e i nā pani kōpa?a no ka mea hā?awi lākou i ka ?ono akā ?a?ole i loa?a ka ?ike calorie i loa?a i ke kōpa?a pākaukau. Ho?ohana pinepine ?ia ?o Sucralose ma ke ?ano he mea ho?ohui i nā mea?ai a me nā mea inu, kū?ai pinepine ?ia ma ke ?ano he "sugar-free" a i ?ole "paona kaumaha" e hō?emi i ka lawe ?ana i ka calorie holo?oko?a.

He aha ka sucralose?

?O ka Sucralose kahi mea ho?ohana nui ?ole no ka mea?ai, ?a?ohe calorie. Ho?opili ?ia ?o Sucralose mai ka papa kōpa?a (table sugar) ma o ke ka?ina hana multi-step e koho koho ana i ?ekolu pū?ulu hydroxyl i loko o ka mole kōpa?a me ?ekolu mau chlorine atoms. Ma hope mai, ua ho?oma?ema?e ?ia ma kahi o 98%. ?O kēia mau ho?ololi kemika e hō?oia i ka sucralose ma kahi o 600 mau manawa ?oi aku ka momona ma mua o ke kō. ?O ka huahana hope he ke?oke?o, crystalline, ?oi aku ka maika?i o ka mea ?ono i ho?ohehe?e ?ia i ka wai. ?O ka ho?ohehe?e ki?eki?e o Sucralose i loko o ka wai he mea kūpono ia no ka ho?ohui ?ana i loko o nā ?ano mea?ai i ho?oponopono ?ia: nā mea?ai i kālua ?ia, nā mea inu, nā ?ōpala, gelatin, a me nā mea?ai waiu malo?o. ?Oi aku ka makemake o ka po?e e ?imi ana i nā mea ?ono ?ē a?e i ka sucralose ma mua o nā mea ?ono ?ē a?e e like me ka aspartame a me ka saccharin. Ma ke ?ano he kumu o ke kō papa?aina, mālama ?ia ka sucralose i kona ?ono "like-like" ma?amau, ?oiai ka nele o ka ?ono ?awa?awa ma?amau i nā mea pani kō. ?O ka ?ono ikaika o ka sucralose e hiki ai i kahi mea li?ili?i ke hele i kahi lō?ihi, e lilo ia i koho kaulana no nā mea?ai ha?aha?a-calorie. He mea li?ili?i ka lawe ?ana o ka sucralose i loko o ka ?ōpū o ka ?ōpū, a ?o ke ala nui o ka excretion ?a?ole i ho?ololi ?ia ka sucralose i loko o ka waihona. No laila, ?a?ohe ka?ina catabolic (breakdown), e hō?oia ana ?a?ole ?o sucralose kahi kumu o ka ikehu a / a i ?ole nā ????calorie. Ua ?ae mua ?ia ke kūlana o ka ?ae ?ana a me ka ho?oponopono ?ana i ka sucralose no ka ho?ohana ?ana ma Kanada i ka makahiki 1991, a ukali ?ia e Australia i 1993 a me New Zealand i 1996. I ka makahiki 1998, ua ?ae ka US Food and Drug Administration (FDA) i ka sucralose no ka ho?ohana ?ana i nā ?ano mea?ai a me nā mea inu 15, a ua ho?onui ?ia kona ho?ohana ?ana ma ke ?ano he mea?ai ma?amau 19lose9 i ?ae ?ia no ka ho?ohana ?ana i ka mea?ai i ka Sucralose. Hui ?Eulopa i ka makahiki 2004. Ho?oponopono ka FDA i ka sucralose ma ke ?ano he mea?ai. Ma lalo o ka Federal Food, Drug, and Cosmetic Act, pono e ?ai nā mea ?ono. Ho?okumu ?ia ka ho?oholo palekana a ka FDA ma luna o nā noi?i holoholona nui a me nā ho?okolohua lapa?au e loiloi ana i ka toxicology, teratogenicity (ka hiki ke ho?oulu i ka male ?ana o ka pēpē i ka wā hāpai), a me ka carcinogenicity. Wahi a nā ?ōlelo a?oa?o FDA, ua ho?onohonoho ?ia ke ki?eki?e o ka sucralose i kēlā me kēia lā (ADI) i ?Amelika Hui Pū ?Ia ma 5 mg / kg paona kino i kēlā me kēia lā (mg / kg / lā). Loa?a nā pōmaika?i o ka ho?ohana ?ana i ka sucralose no ka ho?okele paona ?ole o ka calorie

?A?ole like me ke kōpa?a papa?aina, ?a?ole ?eli ?ia ka sucralose a wāwahi ?ia i loko o ka ?ōpū o ka ?ōpū a ?a?ole hana e like me ka wahie caloric i loko o ko mākou kino. No laila, he koho kaulana ?o Sucralose no ka po?e e ?imi nei e pani i ke kō (1 teaspoon a i ?ole 4.2 grams o ke kō papa?aina he 16 calories) a ho?emi i ka pau ?ana o ka calorie. Ma ka ho?okomo ?ana i ka sucralose i kā lākou mea?ai, hiki i ka po?e ke ho?okō i kā lākou mau mea momona me ka ?ole o ka hopohopo e pili ana i nā calorie ?ē a?e, he mea ko?iko?i ia no ka mālama ?ana i ke kaumaha.

He kūpono no ka mālama ?ana i ka ma?i diabetes

?A?ole ho?ololi ?ia ka sucralose e ko mākou kino no ka ikehu a ?a?ole ia e ho?onui i ke kō koko koko (6). Ma muli o nā noi?i lapa?au o ka sucralose i ka po?e me ka ma?i ma?i, ua ho?oholo ka FDA ?a?ole i ho?opilikia maika?i ?ia ka sucralose i ka mālama koko koko pōkole i ka po?e me ka ma?i diabetes type 2. Eia kekahi, ua hō?ike ?ia kahi ?ano o nā noi?i lapa?au ?a?ole pili ka sucralose i ka homeostasis glucose lō?ihi (e like me ke ana ?ia e ka HbA1c glycosylation) i nā po?e ma?i me ka ma?i diabetes type 2. No laila, ?o ka sucralose kahi koho mea?ono palekana no ka po?e ma?i ma?i e mālama i ka mea?ai ha?aha?a-carb. Eia nō na?e, e like me nā koho mea?ai, pono ka po?e me ka ma?i diabetes e nīnau i kā lākou lā?au lapa?au ho?ohui a hana paha no kahi ho?olālā mea?ai pilikino me ka nānā ?ana i ka pilikia o ka hypoglycemia mai ka ?ai ?ana i ka sucralose. Nā pilikia olakino a me nā hopena ?ao?ao ?Oiai ua loiloi ?ia ka sucralose no ka palekana e nā mea ho?oponopono, ho?opa?apa?a pinepine ?ia ka palekana o ka sucralose a me kāna mau hopena olakino. ?O ka mea nui, nā ha?awina toxicological e loiloi ana i nā hopena o ka ho?oponopono glucose, neurotoxicity, a me ka carcinogenicity i nā holoholona e ho?onāukiuki pinepine i ka mana?o.

Ua hō?ike ?ia nā ha?awina ?o nā mea ?ono artificial, me ka sucralose, e ho?oulu i ka huna ?ana o ka insulin e nā mea ?ono ?ono i hō?ike ?ia ma nā cell beta i ka pancreas, ?oi aku ka nui o ka nele o ka glucose. Ua hō?ike ?ia ?o Sucralose e ho?oulu i ka huna GLP-1. Pono ka GLP-1 no ka homeostasis glucose a ho?onui ma?amau i ka huna ?ana o ka insulin-mediated glucose. I ka wā lō?ihi, hiki i ka ho?onui ?ana i ka nui o ka insulin i loko o ke koko ma hope o ka ?ike ?ana i ka sucralose hiki ke alaka?i i ka pale ?ana o ka insulin ma muli o ka ho?emi ?ana i ka hana receptor. ?O ka homeostasis glucose impaired (ka ho?oponopono ?ana i ke ki?eki?e o ke kō koko) a me ka ho?oha?aha?a ?ana i ka insulin he mau hi?ohi?ona nui e pili ana i nā ma?i metabolic. ?O ka hiki ?ole ke ho?omau hou i ka glucose e ho?opau i ka ho?oponopono kōpa?a koko a alaka?i i ka ho?omohala ?ana o nā ma?i metabolic e like me ka ma?i diabetes type 2, ka momona, a me ka dyslipidemia. Eia kekahi, ua ho?onui nui ?ia ka pilikia o ka ho?omohala ?ana i ka ma?i cardiovascular. Mana?o ?ia nā hopena i ke olakino o ka ?ōpū a me ka microbiome Sucralose "metabolically inert" no ka mea ?a?ole i komo ?ia akā ho?oku?u ?ia i loko o ka waihona. ?O kēia ka mea li?ili?i e lilo i substrate no ka microbiome gut. Eia nō na?e, aia nā hō?ike e hiki ke ho?ololi pololei i ka ?ike sucralose i kā mākou ?ōpū microbiota ma o ka ho?opa?a ?ana i ke kō koko koko a i ?ole ka pane ?ana i ka immune-mediated. Ua hō?ike ?ia nā ha?awina holoholona he nui i ka ?ai ?ana i nā mea momona ?ole (NNS) hiki ke ho?oulu i nā ma?i microbiome intestinal; Ua hō?ike ?ia ka nui o nā bacteria pathogenic a me ka emi ?ana o ka nui o nā hua bacteria maika?i. Eia nō na?e, pono e mālama pono ?ia ka ho?onui ?ana i ka ?ikepili holoholona i ke kanaka, no ka mea hiki ke kaupalena ?ia ko lākou pili i ke olakino kanaka a me nā ma?i. ?O kahi ho?okolohua lapa?au i ho?olālā ?ia e noi?i i nā hopena o ka ?ai ?ana o ka sucralose no ka manawa pōkole (14-lā malo?o malo?o) i ka metabolism glucose i nā hopena o ka lawe pinepine ?ana i kēlā me kēia lā o NNS ma ka ?ōpū microbiota. Ua ho?oholo ka ha?awina ?a?ole i ho?ololi nui ka sucralose i ka waiwai o ka microbiota gut a i ?ole ka like. ?O ka mea like ?ole, ua hō?ike ?ia kahi ho?okolohua ho?okolohua pōkole pōkole e hiki ke ho?opili i ka mea?ai me ka NNS i ka hiki ke hana o ka microbiome kanaka, me ka sucralose ka hopena nui loa. Eia nō na?e, he mea nui e ho?omaopopo i ka nānā ?ana o nā ho?okolohua lapa?au ?elua i nā hopena o ka ho?ohui ?ana o ka NNS pōkole (me ka sucralose), a pono nā manawa lō?ihi e ho?omaopopo pono i nā hopena olakino o ka supplementation NNS ma ka microbiome gut kanaka. ?O nā hopena lō?ihi o ka sucralose a me nā NNS ?ē a?e i ka microbiome ?ōpū kanaka kahi wahi o ka noi?i mau.

?O nā hi?ohi?ona neurological a me ka ho?oponopono ?ana i ka makemake ?Oiai ?o ka sucralose i mana?o ?ia ?a?ole calorie, ho?oulu ia i nā mea ?ono ?ono, ho?oulu i ka huna ?ana o ka insulin i loko o ka pancreas, a ho?omaka i kahi cascade metabolic e like me ke kūlana ?ai. I ka loa?a ?ole o ka glucose, ?o ka huna mau ?ana o ka insulin e ho?iho?i hou i kā mākou metabolic balance a me ka kemika lolo. Ho?opunipuni ?ia ko mākou ?ono i ka mana?o e ?ai ana mākou i ke kō maoli. Ma kahi ho?ā?o crossover randomized, ua hō?ike ka po?e wahine momona i ka ho?onui ?ana i ka hana ma nā wahi o ka lolo e pili ana i ka pane cue mea?ai a me ka ho?oili ?ana i ka uku, e alaka?i ana i ka ho?onui ?ana i ka caloric ma hope o ka ?ai ?ana i ka sucralose. Hā?awi kēia ha?awina i nā hō?ike ko?iko?i e pili ana ka ?ai ?ana i ka sucralose a me nā mea ?ono ?ē a?e me ka ho?onui ?ana i ka ?ai a me ka makemake, ka ?ai nui ?ana, a me ka loa?a ?ana o ke kaumaha a me ka momona.