0102030405
No ke aha e hana ai ka mannitol no nā ma?i ma?i urinary
2025-03-13
- ?O Mannose (a i ?ole D-Mannose) he kō ma?alahi, akā ?a?ole like me ka glucose, ?a?ole ma?alahi ka mannose e ke kino ma hope o ka ?ai ?ana, a ?o 90% o ka mannose e ho?oku?u pololei ?ia ma o ka mimi ma hope o 30 a 60 mau minuke ma hope o ka lawe ?ana, no laila ?a?ole e like me ka glucose, ?a?ole pili ka mannose i ke kō koko, akā pa?a loa i ka mimi. Hiki i ka Mannose ke ho?opilikia i ka metabolism glucose, ke?ake?a i ka waiho ?ana o ka momona, ho?oponopono i ka flora intestinal a komo i ka ho?oponopono immune. ?O ka ho?omaopopo piha ?ana i ke ?ano o ka hana o ka mannose i ka mālama ?ana i nā ma?i pili ke kī e ho?onui ai i kāna noi lapa?au.I nā makahiki i hala iho nei, ua nui nā ha?awina e pili ana i ka mannose. I kēia lā, e kūkākūkā mākou inā he hopena ko ka mannose i ka mālama ?ana i ka ma?i ma?i urinary. ?O ka ma?i urinary tract he ma?i ia i ho?okumu ?ia e ka ma?i bacteria i loko o kekahi ?i?o o ke ala mimi, e like me ka pu?upa?a, ka ?ā?ī, ka ?ōpū, ka urethra, a me nā mea ?ē a?e. Ma muli o nā ?oko?a kino ma waena o nā kāne a me nā wahine, ?oi aku ka nui o ka manawa o ka wahine i ka ma?i ma?i urinary ma mua o nā kāne. Hō?ike nā ha?awina he 50 pākēneka ka loa?a ?ana o ka wahine i ka ma?i ma?i urinary i ko lākou ola ?ana, a ma waena o ka hapakolu a me ka hapa o ka po?e i loa?a i ka ma?i i loko o ho?okahi makahiki.Mai ka makahiki 1980, ua ho?ohana ?ia ka mannose e nā kauka lapa?au hana e mālama ai i nā ma?i ma?i urinary. I nā makahiki i hala iho nei, me ka nui o nā hō?ike noi?i e hō?ike ana i ka hopena therapeutic a me ka pale ?ana o ka mannose, ?o ke kuleana o ka mannose i ka mālama ?ana i ka ma?i urinary tract ua ho?ohuli mālie i ka mana?o o ka lā?au lapa?au.
Pehea e hana ai ka mannose?Ke ho?oku?u ?ia ma o nā pu?upa?a, ?ōpū, a me ka urethra, e ho?opa?a ka mannose i nā ?i?o a me nā hua bacteria e ho?ā?o e pili i nā cell, e hiki ?ole ai i ka bacteria ke ho?opili i ka ?ōpū a me nā pūpū urinary duct, e ālai ana i ke ala o ka ma?i bacteria, a me ka bacteria hiki ?ole ke pili i nā ?i?o urinary tract e hahai i ka mimi i waho o ke kino. ?O ka hapa nui o nā ma?i ma?i urinary tract ke kumu e uropathogenic Escherichia coli (UPEC). Ho?opili ?o UPEC i ka mannose ma ka ?ili o nā pūnaewele epithelial bladder ma o ka protein FimH a ?a?ole hiki ke holoi ?ia e ka mimi. Ua ho?ololi lākou i ka mannose no ka loa?a ?ana o ka mannoside (M4284). ?O kona pilina me ka protein FimH he 100,000 manawa ki?eki?e ma mua o ka mannose, akā ?a?ole ia e pili i ka ?ili o ka ?ōpū a hiki ke ho?oku?u ?ia me E. coli i loko o ka mimi.Ma kahi noi?i honua 2016, ?ike nā mea ma?i i lawe i ka mannose no 13 mau lā i kahi hō?emi nui o nā hō?ailona a me ka ho?omaika?i nui ?ana i ko lākou ola e like me ka loiloi ?ia e nā nīnau nīnau. No ka pale?ana i nā ma?i ma?i urinary tract, ua ho?oka?awale nā ??mea noi?i i nā ma?i i?elua mau pū?ulu, ua ho?omau ka hui hana i ka mannose,?a?ole i loa?a i ka pū?ulu mana. ?O ka hopena o ka hui mannose, he 4.5 pakeneka wale nō o ka ho?i hou ?ana i loko o ?eono mahina, i ho?ohālikelike ?ia me 33.3 pakeneka o ka hui ho?omalu. Ua ho?oholo ka po?e noi?i hiki i ka mannose ke kōkua i ka mālama ?ana i nā ma?i ma?i urinary tract a hiki ke pale maika?i i ka ho?i hou ?ana o nā ma?i urinary tract.