I kēia manawa, ?ehā mau ?ano o ka huaora B12 i ka mākeke API honua. He hydroxycobalamin, Mecobalamin, cyanobalamin a me cobalamin adenosine. ?O kēia ke kumu no ka loa?a ?ana o nā pū?ulu hana like ?ole o ka ion kikowaena i loko o ka mole B12, no laila ua kapa ?ia nā inoa ?oko?a. Kapa ?ia ?o Hydroxycobalamin hydroxycobalamin no ka mea pili ka ion waena o B12 me ka hui hydroxyl. Ma waena o nā molekala B12 ?ehā, ?o ka hydroxycobalamin ka mea ho?ohehe?e wai maika?i loa a me ka metabolism lohi i ka mimi, ?o ia ho?i i ?ike ?ia ?o cobalamin lō?ihi. ?Oiai ?a?ole ho?ohālikelike ka helu absorption me ka cyanocobalan a me Mecobalamin, ?oi aku ka ki?eki?e o kona ?ike i ka maka, hiki ke ho?omaha nui i ka luhi ?ike a hānai i ke a?alolo optic. No laila, loa?a iā ia kekahi hopena curative i ka amblyopia ma muli o ka make ?ana. Eia kekahi, hiki i ka hydroxycobalamin ke hui koke me ka cyanide manuahi e hana i ka cyanobalamine nontoxic i loko o ka wai wai, no laila ?o kāna hopena therapeutic ?ē a?e ka antidote o ka make cyanide.