Nyob rau hauv qhov xwm txheej, mannose muaj nyob hauv lub xeev dawb hauv qee cov txiv hmab txiv ntoo, xws li cranberries, txiv apples, txiv kab ntxwv, thiab lwm yam. Hauv tib neeg lub cev, mannose tau faib rau txhua cov ntaub so ntswg thiab ntshav, suav nrog daim tawv nqaij, kab mob thiab cov hlab ntsha. Hauv cov ntaub so ntswg, mannose koom nrog hauv kev sib txuas ntawm glycoproteins uas tswj kev ua haujlwm ntawm autoimmune system. Cov kev tshawb fawb soj ntsuam yav dhau los tau pom tias mannose tuaj yeem kho thiab tiv thaiv kab mob urinary, yog li qee cov khoom noj qab haus huv txawv teb chaws nrog mannose yog cov khoom tseem ceeb yog siv los tswj cov kab mob urinary.

Nws tau ntev tau paub tias cov qog muaj qhov xav tau ntau dua rau cov piam thaj ntau dua li cov ntaub so ntswg. Cov qog hlwb tuaj yeem noj tau txog li 10 npaug ntawm cov piam thaj ntau npaum li cov hlwb ib txwm muaj thiab vam khom ntau dua ntawm glycolysis rau lub zog los txhawb lawv txoj kev loj hlob sai. Txawm li cas los xij, "qab zib zoo li lub neej" qog, nyob rau hauv lub ntsej muag ntawm mannose, tab sis muaj qhov sib txawv tshwm sim. Nyob rau hauv 2018, phau ntawv journal Nature tau luam tawm kev tshawb fawb blockbuster los ntawm Cancer Research UK tias mannose tuaj yeem cuam tshuam cov qog. Cov kws tshawb fawb pom tias tom qab mannose nkag mus rau hauv cov qog hlwb, nws nkag mus rau hauv cov hlwb hauv daim ntawv ntawm mannose 6-phosphate, thaiv cov qog lub zog los ntawm kev cuam tshuam nrog cov piam thaj metabolism, yog li inhibiting kev loj hlob ntawm cov qog hlwb. Txhawm rau kom paub meej qhov kev txiav txim siab no, cov kws tshawb fawb tau tshawb nrhiav ntxiv hauv tus qauv qog nqaij hlav nas, lawv ntxiv mannose rau cov dej haus ntawm cov nas "mob qog noj ntshav", thiab tshuaj xyuas cov nyhuv ntawm qhov ncauj mannose ntawm kev kho mob ntawm ntau hom mob qog noj ntshav xws li mob qog noj ntshav thiab mob ntsws cancer hauv cov nas. Cov txiaj ntsig tau pom tias kev tswj hwm qhov ncauj ntawm mannose los ntawm kev haus dej zoo ncua kev loj hlob ntawm cov nas. Tom qab lees paub qhov kev kho mob ntawm mannose hauv tus qauv qog nas, cov kws tshawb fawb tau txiav txim siab siv mannose rau cov nas ntxiv rau kev kho mob rau kev kho mob ntxiv, thiab lawv xav tsis thoob thaum pom tias mannose txhim kho cov kev kho mob ntawm cov kws khomob, tsis yog tsuas yog txo cov qog ntim hauv cov nas, tab sis kuj tseem txuas ntxiv lub neej ntev ntawm cov nas. Xyoo no, pab pawg tshawb fawb Fudan University tau pom ib txoj hauv kev tshiab ntawm mannose los tiv thaiv qog noj ntshav - tswj lub cev tiv thaiv kab mob molecule PD-L1. Qhov chaw kuaj mob qog nqaij hlav yog dab tsi? Peb paub tias thaum lub cev txawv teb chaws xws li cov kab mob sab nraud thiab cov kab mob nkag mus lossis cov hlwb hauv lub cev tuag lossis ua mob qog noj ntshav, lub cev tsis muaj zog ntawm tib neeg lub cev yuav raug qhib, thiab lub cev tiv thaiv kab mob yuav ua lub luag haujlwm tom qab tau qhib kom tshem tawm cov "alien molecules". Nyob rau tib lub sijhawm, txhawm rau kom tsis txhob muaj kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab "kev tua neeg tsis raug cai" ntawm cov ntaub so ntswg ib txwm nyob hauv lub cev, muaj cov txheej txheem "kev tiv thaiv kab mob hauv lub cev" hauv peb lub cev. PD-L1 yog ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob molecule hauv peb lub cev, uas tuaj yeem khi rau PD-1 molecule nyob rau saum npoo ntawm lub cev tiv thaiv kab mob thiab xa cov teeb liab "brake" rau lub cev tiv thaiv kab mob kom tsis txhob tua cov kab mob hauv lub cev los ntawm lub cev tiv thaiv kab mob (Daim duab 2). Txawm li cas los xij, lub tshuab nres no hauv peb lub cev yog siv los ntawm cov qog qog hlwb, thiab T hlwb hauv cov qog microenvironment yog lub luag haujlwm tua cov qog, thiab cov qog hlwb yuav tso tawm "brake" cov cim rau T hlwb los ntawm kev qhia siab ntawm PD-L1 molecules, inhibiting cov haujlwm ntawm T hlwb, kom tsis txhob tua cov kab mob hauv lub cev.

PD-L1 molecule yog cov protein ntau hauv kev hloov kho glycosylation. Pab pawg tshawb fawb ntawm Fudan University pom tias mannose tuaj yeem rhuav tshem qhov ruaj khov ntawm PD-L1 protein los ntawm kev tswj cov glycosylation ntawm PD-L1 molecules, yog li txhawb kev degradation ntawm PD-L1 molecules. Yog li, thaum lub PD-L1 molecule uas tau hais tawm hauv cov qog hlwb raug degraded los ntawm mannose, cov qog hlwb puas tuaj yeem tsis yuam T hlwb kom "tshem"? Cov kws tshawb fawb tau lees paub qhov kev xav: cov qog hlwb kho nrog mannose feem ntau yuav raug tua los ntawm T hlwb; Hauv cov qauv nas qog, qhov ncauj mannose tuaj yeem txhawb nqa kev ntxeem tau thiab tua T cell mus rau cov qog thiab inhibit qhov kev loj hlob ntawm cov qog, thiab kev sib xyaw ntawm mannose thiab lub cev tiv thaiv kab mob tshuaj tiv thaiv kab mob ntxiv txhawb kev cuam tshuam thiab tua cov T hlwb rau cov qog, thiab txuas ntxiv lub neej ntev ntawm "mob cancer" nas.

Raws li peb tau hais ua ntej, mannose pom muaj nyob hauv qee cov txiv hmab txiv ntoo, tshwj xeeb tshaj yog cranberries nrog cov ntsiab lus mannose siab tshaj plaws (Daim duab 3). Ntau tus neeg yuav xav tsis thoob, tuaj yeem noj cranberries tiv thaiv lossis kho mob qog noj ntshav? Qhov tseeb, qhov concentration ntawm mannose muab rau cov nas "mob qog noj ntshav" hauv ob qhov kev tshawb fawb saum toj no yog siab li 20%, uas txhais tau hais tias txhua txhua 100ml ntawm cov dej haus muaj 20g ntawm mannose, uas yog qhov muaj zog thiab ntau npaum li cas. Yog li ntawd, peb noj cranberries thiab lwm yam txiv hmab txiv ntoo kom ntau npaum li cas mannose, muaj peev xwm txhawb kev tiv thaiv kab mob, pab rau kev noj qab haus huv, tab sis xav kom ua tiav cov nyhuv ntawm anti-cancer cranberries ib leeg yog deb ntawm txaus.