1, Core mechanism

Targeted kab mob metabolite glyoxylate

Cov kab mob tshuaj tiv thaiv kab mob txhim kho qhov kev qhia ntawm glyoxylate nyob rau hauv qhov chaw tsis muaj zaub mov, uas hloov kho cov yam ntxwv ntawm epigenetic, ua rau lub cev tsis muaj zog, thiab pab cov kab mob muaj sia nyob hauv cov tshuaj tua kab mob los ntawm inhibiting cov haujlwm ntawm DNA demethylase (TET2) hauv cov tswv tsev.

Vitamin C activates TET2 enzyme kev ua haujlwm

Vitamin C, raws li lub ntuj activator ntawm TET2, tuaj yeem tiv thaiv cov nyhuv inhibitory ntawm glyoxylate ntawm tus tswv tsev tiv thaiv, rov ua kom DNA demethylation muaj nuj nqi, thiab rov pib lub cev tiv thaiv kab mob.

Kev cuam tshuam lub tswv yim ntawm "kev tuag cuav" ntawm cov kab mob

Acetaldehyde ib txhij activates tus kheej-tiv thaiv mechanism ntawm cov kab mob, tsim persisters mus evade tshuaj tua kab mob. Vitamin C ua ke nrog cov tshuaj tua kab mob tuaj yeem rhuav tshem cov kab mob metabolic no thiab txo cov kab mob hnyav.

2 、 Kev sim ua pov thawj

Tsiaj qauv validation: Hauv tus qauv nas kab mob, kev sib xyaw ntawm cov vitamin C thiab tshuaj tua kab mob ua kom muaj sia nyob tau 60%, txo cov kab mob hauv cov ntaub so ntswg los ntawm 80%, thiab txo qis ntawm cov kab mob inflammatory los ntawm 50%.

Synergistic nyhuv: Vitamin C txhim khu lub interferon (IFN) taw qhia txoj hauv kev, ntxiv dag zog rau lub cev tiv thaiv kab mob lub peev xwm los tshem tawm cov tshuaj tiv thaiv kab mob, thiab inhibits STAT1 dephosphorylation, prolonging cov tshuaj tiv thaiv qog.

3 、 Clinical daim ntawv thov muaj peev xwm

Kev kov yeej qhov teeb meem ntawm kev siv tshuaj tiv thaiv: Lub tswv yim no muab cov kev kho tshiab uas tsis yog tshuaj tua kab mob rau cov kab mob tiv thaiv kab mob xws li Salmonella thiab Mycobacterium tuberculosis, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob rov qab los yog cov tshuaj tua kab mob tsis zoo.

Kev npaj kho mob yooj yim: Vitamin C, raws li cov khoom noj muaj txiaj ntsig zoo thiab tus nqi qis, tuaj yeem siv ua ke nrog cov tshuaj tua kab mob uas twb muaj lawm los txo cov tshuaj noj thiab txo cov kev mob tshwm sim.

Kev tiv thaiv tus nqi ntxiv: Kev noj kom txaus ntawm cov micronutrients (xws li vitamin C) tuaj yeem txo qis kev pheej hmoo ntawm cov tshuaj tiv thaiv kab mob los ntawm kev tswj cov plab hnyuv microbiota.

4 、 Cov lus qhia kev tshawb fawb yav tom ntej

Tshawb nrhiav cov teebmeem kev sib koom ua ke thiab kev pom zoo ntawm cov tshuaj vitamin C nrog rau lwm cov tshuaj tua kab mob xws li beta lactams thiab quinolones.

Ntsuam xyuas qhov cuam tshuam ntawm kev siv cov vitamin C mus sij hawm ntev ntawm cov evolution ntawm cov tshuaj tiv thaiv kab mob.

Tsim cov tshuaj tua kab mob tshiab uas tsom mus rau glyoxylic acid-TET2 axis