Lycopene (LYC), carotenoid, yog cov xim muaj roj-soluble, feem ntau pom muaj nyob rau hauv txiv lws suav, txiv lws suav, txiv kab ntxwv thiab lwm yam txiv hmab txiv ntoo, yog cov xim tseem ceeb hauv txiv lws suav. Lycopene muaj ntau yam txiaj ntsig kev noj qab haus huv, suav nrog kev tshem tawm cov dawb radicals, txo qhov mob, tswj cov piam thaj thiab lipid metabolism, thiab cov teebmeem neuroprotective.

Tsis ntev los no, Cov kws tshawb fawb los ntawm Shanxi Medical University tau luam tawm ib daim ntawv nyob rau hauv phau ntawv journal Redox Biology hu ua "Lycopene alleviates hnub nyoog txog kev txawj ntse tsis txaus los ntawm kev ua kom lub siab-hlwb hlwb. Kev tshawb fawb daim ntawv ntawm fibroblast kev loj hlob factor-21 signaling".

Cov kev tshawb fawb tau pom tias ntxiv nrog lycopene rau 3 lub hlis tuaj yeem ncua lub hlwb laus hauv cov nas thiab txo cov hnub nyoog ntsig txog kev puas hlwb, thiab lycopene txhim kho neuronal degeneration, mitochondrial dysfunction, synaptic puas, thiab txhawb synaptic vesicle fusion hauv cov nas laus.

Tsis tas li ntawd, lycopene activated lub siab-hlwb axis FGF21 signaling nyob rau hauv cov laus nas, yog li txhawb kev tso tawm ntawm neurotransmitters los ntawm nce mitochondrial ATP qib thiab txhim kho synaptic vesicular fusion. Qhov no qhia tias FGF21 tuaj yeem yog lub hom phiaj kho mob hauv cov tswv yim kev noj zaub mov kom ncua lub hlwb laus thiab txhim kho lub hnub nyoog ntsig txog kev paub tsis meej.

Hauv kev laus, lub hlwb laus, mitochondrial dysfunction yog ib qho tseem ceeb tshaj plaws, cov kws tshawb fawb pom tias lycopene supplementation tuaj yeem txhim kho mitochondrial morphological puas, thiab thim rov qab qib ntawm mitochondrial electron thauj saw complex tshwm sim los ntawm kev laus, txhawb kev tsim cov ATP, qhia tias lycopene muaj kev tiv thaiv kev ua haujlwm ntawm mitochondrial.

Thaum kawg, cov kws tshawb fawb kuj tau ua hauv vitro thwmsim thiab pom tias lycopene txhim kho lub peev xwm ntawm daim siab hlwb los txhawb cov neurons, nrog rau kev txhim kho cell aging, txhim kho mitochondrial muaj nuj nqi, thiab nce neuron axon ntev.

Noj ua ke, cov txiaj ntsig tau qhia tias kev ntxiv lycopene tuaj yeem ncua lub hlwb kev laus thiab tiv thaiv lub hnub nyoog ntsig txog kev paub tsis meej hauv nas, ib feem vim tias lycopene activates hepato-brain axis FGF21 signaling, tawm tswv yim tias FGF21 tej zaum yuav yog lub hom phiaj kho mob hauv kev noj zaub mov kom zoo rau lub hnub nyoog kev txawj ntse thiab kev puas tsuaj los ntawm cov kab mob neurogenic.