(1) Tej yam tshwm sim ntawm lub neej

Raws li ib tug natural monosaccharate, mannose tau pom nyob rau hauv lub epidermis ntawm txiv apples (0.7-1.2%) thiab txiv kab ntxwv (0.3-0.8%). Nws cov qauv molecular yog ?. C?H??O? thiab qabzib ?. 8. Thaum tib neeg cov metabolism, mannose nkag mus rau hauv cov hlwb los ntawm ib qho kev thauj mus los, GLUT1, tab sis tsis ua kom cov tshuaj insulin-secreting system, uas ua rau nws muaj kev nyab xeeb rau cov neeg mob ntshav qab zib 78.

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(2) Qhov nce ntawm cov khoom noj khoom haus tshiab

Xyoo 2023, National Health Commission tau teev npe konjac mannose oligomeric raws li cov khoom noj tshiab, kos npe rau kev nkag ntawm mannose rau hauv daim ntawv thov kev lag luam zaub mov 7. Lub degree ntawm polymerization ntawm mannose oligosaccharide tau los ntawm enzymatic hydrolysis ntawm konjac glucomannan yog tswj nyob rau hauv 2-10 qab zib units, uas tsis tsuas yog khaws cia tej yam ntuj tso khoom, tab sis kuj muaj kev adaptability. 7 tau siv ntau tshaj 20 yam khoom noj xws li dej qab zib tsis muaj qab zib thiab ua haujlwm biscuits.

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Qhov thib ob, kev noj qab haus huv empowering mechanism ntawm mannose

(a) natural barrier ntawm lub urinary ib ntsuj av

Cov ntaub ntawv kho mob qhia tau tias 2g ntawm mannose ib hnub twg tuaj yeem txo qhov tshwm sim ntawm cov kab mob urinary nyob rau hauv cov poj niam los ntawm 38% 8. Nws mechanism ntawm kev txiav txim muaj xws li:

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Kev tshem tawm lub cev: 90% ntawm kev noj haus tau tawm los ntawm cov zis hauv 30-60 feeb, thiab cov kab mob pathogenic (xws li E. coli) raug tawm ntawm lub cev 8;

biofilm cracking : rhuav tshem β-1, 4-glucoside daim ntawv cog lus ntawm cov kab mob biofilm, txhim kho cov kab mob bactericidal ntawm cov tshuaj tua kab mob los ntawm 3 zaug 78;

Kev tiv thaiv kab mob: txhawb kev zais ntawm defensin los ntawm urethral epithelial hlwb, txhim khu kev tiv thaiv hauv zos 8.

(2) Tus neeg saib xyuas tsis pom ntawm txoj hnyuv

Konjac mannooligosaccharide tuaj yeem nthuav tawm cov kab mob probiotics xws li bifidobacterium, thiab ua kom cov plab hnyuv ntau ntxiv los ntawm 25% 7. Hauv kev sim tshuaj ntawm Wuhan Union Medical College Tsev Kho Mob, tom qab noj mannose oligosigro rau 4 lub lis piam, qhov ntau zaus ntawm kev tso quav tso zis tau nce los ntawm 2.3 mus rau 4.1 zaug hauv ib lub lis piam, thiab qhov tshwm sim ntawm plab hnyuv tau txo los ntawm 62% 7.

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(3) Ib qho cuab yeej rau kev tiv thaiv thiab tswj cov kab mob metabolic

Tsis zoo li cov khoom qab zib, mannose muaj glycemic Performance index (GI) ntawm 0, thiab hloov sucrose hauv cov khoom ci txo cov ntshav qab zib tom qab los ntawm 2.1 mmol / L hauv cov neeg mob ntshav qab zib 78. Kev tshawb fawb 2024 Journal of Nutrition tau lees paub tias mannose txhim kho cov piam thaj tsis haum rau cov neeg mob insulin 7 los ntawm kev ua kom AMPK txoj hauv kev.

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3.Innovative kev coj ua hauv kev lag luam zaub mov

(1) Piv txwv ntawm kev txhim kho khoom noj khoom haus

Cov dej haus tiv thaiv zis: 500mg / lub raj mis ntawm mannose oligosaccharide tau ntxiv rau cov dej haus cranberry complex ntawm ib hom tshuaj, thiab qhov muag ntim tau tshaj 2 lab tus neeg nyob rau hauv thawj ib nrab xyoo 7;

Kev tswj cov piam thaj hauv cov khoom qab zib : noj mov hloov mov ci ua nrog konjac thiab mannose-oligosaccharide muaj 45% tsawg carbohydrate thiab peb zaug fiber ntau 7;

Kev tiv thaiv kev noj qab haus huv rau cov menyuam yaus : Cheese sticks nrog mannose ntxiv tuaj yeem txhawb nqa calcium nqus ntawm 18%, uas tau suav nrog 30% qib kindergarten zaub mov system 7.

(2) Txhim kho hauv kev ua cov thev naus laus zis tshiab

Txoj kev qhia enzymatic hydrolysis thev naus laus zis tsim los ntawm Hubei cov tuam txhab tau nce kev hloov pauv ntawm konjac glucomannan los ntawm 58% mus rau 92%, thiab txo cov nqi tsim khoom los ntawm 40% 7. Daim ntawv thov ntawm microencapsulation txheej txheem tau txuas ntxiv kev ruaj ntseg ntawm mannose mus rau 60 feeb ntawm 120 ℃, thiab nthuav nws daim ntawv thov nyob rau hauv lub tshav pob ntawm ci 78.

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4.Scientific cognition thiab rational thov

(1) Txoj Cai Golden ntawm kev tswj tshuaj

Kev nyab xeeb pib: ib qho kev noj haus tsis pub tshaj 3g, kev noj txhua hnub yog tswj tsis pub dhau 5g, ntau dhau yuav ua rau mob plab, raws plab (xws li 7%) 8;

Kev ceeb toom tshwj xeeb rau pej xeem: cov neeg mob lub raum tsis txaus tso tawm tus nqi qis dua 50%, yuav tsum siv 8 raws li kev qhia ntawm tus kws kho mob;

Synergistic scheme : Ua ke nrog cranberry extract, antibacterial nyhuv nce 2.3 npaug 8.

(2) Kev lag luam evolution ntawm cov qauv cim

Txoj Cai Kev Noj Qab Haus Huv Tag Nrho Cov Khoom Noj Prepackaged raws li tau hloov kho hauv 2024 xav tau:

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Mannose yuav tsum tau muab cim cais nyob rau hauv cov khoom xyaw thiab yuav tsum tsis txhob muab tov nrog lub ntsiab lus "sweetener" 7;

Cov ntawv thov kev ua haujlwm yuav tsum raug cim "tsis yog rau lwm txoj kev kho tshuaj" 8;

Cov koob tshuaj ≥1g / 100g yuav tsum raug cim "yuav ua rau mob plab hnyuv me" 7.

1.Kev tsis sib haum xeeb thiab kev cia siab rau yav tom ntej

(1) Qhov tseem ceeb ntawm kev tsis sib haum xeeb

Cov teebmeem mus sij hawm ntev yuav tsum tau soj ntsuam : cov txiaj ntsig ntev ntawm kev noj cov khoom noj tsis tu ncua rau ntau tshaj 5 xyoo ntawm cov hnyuv tsis meej 7;

Naturalness : Seb cov txheej txheem enzymatic hydrolysis hloov cov khoom tseem ceeb ntawm cov khoom ua rau kev kawm sib tham 7;

Ecological chain impacts : Konjac cultivation expansion tau ua rau kev hloov pauv ntawm 30% ntawm cov qoob loo ib txwm muaj, uas yuav cuam tshuam rau biodiversity 7.

(2) Kev taw qhia txog kev tsim kho tshuab

Daim ntawv thov precision : Kev loj hlob ntawm mannose derivatives tshwj xeeb rau ntau hom 8;

ntsuab ntau lawm : Konjac ntau yam txhim kho los ntawm CRISPR thev naus laus zis, cov ntsiab lus glucomannan nce ntawm 60% mus rau 85% 7;

Kev soj ntsuam ntse : Wearable device saib xyuas cov zis mannose concentration hauv lub sijhawm tiag tiag rau tus kheej ntxiv 8.

Xaus

Raws li tus qauv ntawm kev sib koom ua ke ntawm xwm thiab thev naus laus zis, mannose tsis tsuas yog txuas ntxiv cov kev txawj ntse thaum ub nyob rau hauv cov txiv apples, tab sis kuj tseem ci ntsa iab ntawm cov khoom noj niaj hnub engineering. Raws li kev taw qhia ntawm Healthy China 2030 lub tswv yim, qhov kev ua haujlwm zoo thiab muaj kev nyab xeeb yog hloov kho thaj tsam ntawm tib neeg txoj kev nkag siab ntawm cov khoom noj ntxiv. Txawm li cas los xij, nws yog ib qho tsim nyog yuav tsum paub tias kev siv cov khoom siv ntxiv yuav tsum yog raws li kev noj zaub mov kom zoo, raws li "Unavoidable Food Additives" hais tias: "Kev tshawb fawb thiab thev naus laus zis tau ua zaub mov ntau dua, tab sis kev hwm rau xwm ib txwm yog lub hauv paus ntawm kev lag luam zaub mov.