Citicolinetau dav siv nyob rau hauv kev kho mob, feem ntau yog rau kev kho mob ntawm neurological sequelae los ntawm craniocerebral raug mob los yog cerebrovascular kev huam yuaj, thiab tau pom tshiab siv nyob rau hauv kev kho mob xyaum. Nws txoj kev kho mob hauv cerebral hemorrhage, Parkinson's disease, glaucoma, ntshav qab zib peripheral neuropathy thiab tinnitus thiab lwm yam kab mob kuj tau txais kev saib xyuas ntxiv. Yog li ntawd, citicoline yog dab tsi, cov tshuaj pharmacological dab tsi, nws cov lus qhia (kev kho tshwj xeeb ntawm cov kab mob), kev ua tau zoo thiab kev nyab xeeb?

Citicoline yog ib qho nucleotide uas muaj ribose, cytosine, pyrophosphate thiab choline. Nws yog endogenous nucleotide ntawm tib neeg lub cev. Nws koom nrog ntau txoj hauv kev tseem ceeb hauv metabolic hauv lub cev. Nws yog ib tug natural precursor ntawm phospholipid synthesis ntawm neuron cell membrane qauv thiab ib tug precursor ntawm biosynthesis ntawm neurotransmitter acetylcholine.

Citicoline yog ib qho tshuaj tiv thaiv kab mob neuroprotective uas tuaj yeem tiv thaiv cov neurons tsis zoo, yog li txo lossis tiv thaiv kev kis kab mob. Tam sim no, cov tshuaj tiv thaiv neuroprotective feem ntau siv hauv kev kho mob suav nrog calcium channel blockers, glutamate antagonists, dawb radical scavengers, thiab cell membrane stabilizers, ntawm cov citicoline belongs rau cell membrane stabilizers.

Citicolinemuaj ntau lub hom phiaj pharmacological, thiab cov txheej txheem ua haujlwm no ua rau nws muaj peev xwm tseem ceeb hauv kev tiv thaiv kab mob thiab kho paj hlwb. Nws muaj cov nyhuv neuroprotection ntawm thaiv qhov tshwm sim ntawm neuronal raug mob thiab kho paj hlwb tom qab qhov tshwm sim ntawm kev raug mob neuronal, uas nthuav dav lub sijhawm kho lub qhov rais ntawm citicoline.

Raws li nws cov khoom siv tshuaj, citicoline tau siv dav hauv kev kho mob stroke, kev paub tsis meej, kev raug mob lub hlwb, Parkinson's disease, glaucoma, ntshav qab zib peripheral neuropathy, tinnitus thiab lwm yam kab mob, thiab nws cov txiaj ntsig thiab kev nyab xeeb tau raug txheeb xyuas hauv ntau qhov kev tshawb fawb, nrog cov ntaub ntawv pov thawj txaus-raws li kev kho mob. Stroke: mob stroke yog ib hom mob hlab ntsha tawg lossis tawg, ua rau lub hlwb puas ntawm cov kab mob, suav nrog ischemic thiab hemorrhagic stroke, ntawm cov ischemic stroke yog hom mob stroke, suav txog 75% txog 90% ntawm tag nrho cov mob stroke. Lub neej txoj kev pheej hmoo ntawm mob stroke hauv peb cov pej xeem yog 35% -40.9%, qeb thib ib hauv ntiaj teb, tsis tas li ntawd, mob stroke kuj yog thawj qhov ua rau tuag thiab kev tsis taus ntawm peb cov neeg nyob.

Cov ntaub ntawv tshawb fawb soj ntsuam:

1. Nyob rau xyoo 2002, American Journal Stroke tau luam tawm ib qho kev soj ntsuam ntawm kev soj ntsuam ntawm cov neeg mob uas mob ischemic stroke, uas qhia tau hais tias qhov ncauj citicoline ua rau cov neeg mob stroke rov zoo tom qab 3 lub hlis [1].

2. Nyob rau hauv 2009, kev soj ntsuam tshuaj soj ntsuam kev tshawb fawb tau ua nyob rau hauv Kaus Lim Qab Teb rau 4191 cov neeg mob uas mob stroke ischemic, thiab cov txiaj ntsig tau pom tias citicoline txhim kho NIHSS tus qhab nia thiab BI qhab nia ntawm cov neeg mob nrog cov txiaj ntsig ntawm kev kho mob ntxov thiab lig, thiab cov txiaj ntsig ntawm kev siv mus sij hawm ntev tau ntau dua, thiab cov txiaj ntsig kho tau zoo cuam tshuam nrog kev noj tshuaj. Qhov kev txhim kho yog qhov tseem ceeb nyob rau hauv pab pawg neeg siab (≧2000mg / hnub), thiab daim ntawv thov mus sij hawm ntev muaj kev nyab xeeb thiab zam tau [2].

3. Cov txiaj ntsig ntawm ntau qhov chaw, randomized, ob qhov muag tsis pom kev, cov tshuaj placebo-tswj txoj kev tshawb fawb ntawm cerebral hemorrhage qhia tias citicoline yog cov tshuaj muaj kev nyab xeeb rau kev kho mob cerebral hemorrhage nrog cov txiaj ntsig zoo [3].

4. Ib qho qhib-label, randomized, parallel txoj kev tshawb fawb tau soj ntsuam cov txiaj ntsig ntawm citicoline ntawm kev puas siab puas ntsws post-stroke, thiab cov txiaj ntsig tau pom tias kev siv citicoline mus sij hawm ntev tau txhim kho kev puas siab puas ntsws post-stroke [4].