SAIB (sucrose isobutyrate acetate) yog cov tshuaj qib tshuaj ntau yam khoom siv. Nws yog cov kua nplaum uas npaj los ntawm kev tswj hwm esterification ntawm ntuj qab zib (sucrose) nrog acetic acid thiab isobutyric anhydride. Nws yog ib tug sib tov uas tsim los ntawm distillation thiab purified ntau lawm. Nws tuaj yeem siv los ua cov khoom siv tso tawm kom ruaj khov, hnyav / cov cab kuj thiab tshuaj tua kab mob inhibitor.

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SAIB Product features

SAIB yog cov kuab tshuaj zoo tshaj plaws / cov cab kuj rau hydrophobic API thiab muaj kev tso tawm qeeb.

SAIB tsis crystallize thiab tseem amorphous nyob rau hauv chav tsev kub, uas zoo heev txhawb ib tug tas li tus nqi ntawm cov tshuaj xa tuaj;

SAIB tsis yog-polymeric thiab tsis coagulate los yog precipitate thaum nyob rau hauv kev sib cuag nrog aqueous lub cev kua. SAIB yog soluble hauv ntau cov kuab tshuaj organic thiab sib xws nrog ntau cov ntaub ntawv; SAIB tuaj yeem tawg hauv dej nrog kev pab ntawm cov kuab tshuaj organic.

SAIB muaj cov khoom siv bioadhesive thiab tuaj yeem siv rau kev siv transdermal, sublingual thiab buccal thaj daim ntaub ntawv.

Daim ntawv thov khoom

1. ncua kev tso tawm

Hauv daim duab saum toj no, nws tuaj yeem pom tias SAIB muaj tus nqi HLB kwv yees li 5, qhia tias nws yog hydrophobic.

2. Tsis zoo dej solubility API kua

Hydrophobic SAIB yog cov kuab tshuaj zoo / cov cab kuj rau API nrog cov dej tsis zoo solubility, thiab kev siv SAIB txhim kho cov kua dej ntawm cov khoom lag luam insoluble.

3. Tiv thaiv kev siv yeeb tshuaj

Kev siv SAIB nce qhov loj me ntawm cov tshuaj opioids thaum sib tsoo thiab cuam tshuam nrog cov tshuaj rho tawm.

(1) Polymers (polyoxyethylene thiab / los yog hydroxypropyl methylcellulose) thiab tocopherol acetate yog granules ua los ntawm cov kua dej cawv ntawm SAIB. Cov kev npaj tau muab faib ua Uncured / Uncured los yog kub-kho / Kho (kho 90oC rau 30 feeb).

(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene thiab / los yog hydroxypropyl methylcellulose) thiab tocopherol acetate yog granules ua los ntawm cov kua dej cawv ntawm SAIB. Cov kev npaj tau muab faib ua Uncured / Uncured los yog kub-kho / Kho (kho 90oC rau 30 feeb).

Kev soj ntsuam kev tsim txom ntawm qhov ntswg pom tau tias SAIB siv cov hmoov loj ntxiv thaum lub sij hawm sib tsoo, nrog rau 47% ntawm cov hmoov sib tsoo loj dua 1 hli.

Piv nrog rau pawg tswj hwm, cov nyiaj rho tawm ntawm SAIB hauv dej, 0.1% N HCl thiab 0.1% N NaOH cov kuab tshuaj txo los ntawm 41.3% -42.5%, 24.8% -26.1% thiab 37.4% -50.6%, feem. Kev siv cov kuab tshuaj organic rau kev rho tawm ua rau cov nplaum nplaum uas nyuaj dhau los ntawm ntau txoj hauv kev ntawm kev tswj hwm (xws li, txhaj tshuaj, noj, snorting, thiab lwm yam), tiv thaiv kev siv yeeb tshuaj.

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Kev siv SAIB, tsis muaj txheej, tuaj yeem sib xyaw ncaj qha nrog API kom ncua kev tso tshuaj thiab ua tiav kev tso tawm.

Hydrophobic SAIB, uas tuaj yeem tawg hauv dej nrog kev pab ntawm cov kuab tshuaj organic, tuaj yeem siv nrog hydrophobic lossis hydrophilic apis; SAIB tuaj yeem txhim kho qhov solubility ntawm API nrog cov dej tsis zoo solubility thiab yog cov kuab tshuaj zoo heev thiab cov cab kuj rau API nrog cov dej tsis zoo.

Kev siv SAIB tiv thaiv kev siv yeeb tshuaj los ntawm kev ua kom qhov loj me ntawm cov tshuaj thaum nws nyob hauv av, cuam tshuam nrog kev tshem tawm cov tshuaj, thiab ua rau nws nyuaj rau cov tshuaj kom nqus tau los ntawm ntau txoj hauv kev ntawm kev tswj hwm.

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