Lub peev xwm ntawm mannose hauv kev lag luam tshuaj feem ntau yog tsom rau ntau cov lus qhia tshwj xeeb, qee qhov twb tau siv tshuaj kho mob (xws li kev tiv thaiv kab mob urinary), thaum lwm tus yog nyob rau hauv kev tshawb fawb hauv paus lossis kev sim tshuaj thaum ntxov. Cov kev cia siab no tsim nyog tau txais kev saib xyuas, tab sis xav tau ntau cov pov thawj los txhawb lawv. Piav txog nws lub peev xwm hauv thaj chaw hauv qab no:

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1 、 Kev lees paub / Mature Application Fields

Tiv thaiv kab mob urinary tract (rUTI) ?

Mechanism: Kev tswj hwm qhov ncauj ntawm mannose ua rau muaj kev tawm dag zog ntau hauv cov zis, sib tw thaiv kev khi ntawm FimH pilin adhesins los ntawm cov kab mob xws li Escherichia coli mus rau lub zais zis epithelial hlwb, tiv thaiv kab mob los ntawm colonizing thiab ntxuav tawm los ntawm cov zis.

Cov pov thawj:

Ntau qhov kev tshawb fawb soj ntsuam, xws li kev sib piv nrog cov tshuaj tua kab mob furantoin, tau pom tias 1.5-2g ntawm mannose ib hnub twg zoo li cov tshuaj tua kab mob qis hauv kev tiv thaiv rUTI los ntawm Escherichia coli hauv cov poj niam, thiab muaj kev pheej hmoo tsawg dua.

Lub koom haum European ntawm Urology (EAU) cov lus qhia sau nws ua lwm txoj hauv kev tiv thaiv rUTI (Qib Cov Ntawv Pov Thawj: B).

Qhov zoo: Kev nyab xeeb siab (mob plab hnyuv loj), tsis muaj kev pheej hmoo ntawm broad-spectrum tshuaj tiv thaiv.

Kev txwv: Tsuas yog siv tau rau kev tiv thaiv thiab tsis tuaj yeem hloov cov tshuaj tua kab mob hauv kev kho tus kab mob hnyav; Cov nyhuv ntawm cov tsis Escherichia coli UTI yog txwv.

2 、 Cov cheeb tsam hauv kev tshawb fawb theem tab sis muaj peev xwm meej

Kev Kho Mob Congenital Glycation Disorder (CDG)

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Mechanism: Qee cov CDG subtypes, xws li MPI-CDG (CDG-Ib hom), tsis muaj phosphomannose isomerase (PMI), uas tiv thaiv kev hloov pauv ntawm mannose-6-phosphate rau fructose-6-phosphate, ua rau ntau lub cev tsis ua haujlwm.

Kev Kho Mob: Kev tswj hwm qhov ncauj ntawm mannose tuaj yeem hla PMI qhov tsis xws luag thiab ncaj qha muab mannose-6-phosphate, rov kho glycoprotein synthesis.

Qhov xwm txheej tam sim no:

FDA tau pom zoo siv mannose rau MPI-CDG, uas yog ib qho ntawm ob peb hom kev kho mob ntawm CDG.

Kev txhim kho tseem ceeb hauv daim siab kab mob, coagulation dysfunction, thiab cov tsos mob ntawm plab hnyuv, tab sis yuav tsum tau noj tshuaj tas mus li.

Muaj peev xwm: Tshawb xyuas tus nqi kho mob rau lwm yam CDG subtypes, xws li ALG-CDG.

Antitumor kev tiv thaiv kab mob thiab kev xa tshuaj ???? (Active preclinical research)

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Mechanism:

Targeted qog microenvironment: Cov qog txuam nrog macrophages (TAMs) qhia cov mannose receptors (MRC1), thiab mannose hloov cov tshuaj tuaj yeem xa mus rau cov qog nqaij hlav hauv lub hom phiaj.

Kev tswj lub cev tiv thaiv kab mob: Mannose sib tw inhibits mannose receptors nyob rau saum npoo ntawm TAMs, thaiv lawv qhov kev lees paub ntawm mannose glycated antigens ntawm cov qog hlwb, uas tuaj yeem thim rov qab tiv thaiv kab mob.

Txhim khu kev kho mob rhiab heev: Hauv kev tshawb fawb tsiaj, kev sib xyaw ntawm mannose thiab kws khomob (xws li doxorubicin) tuaj yeem cuam tshuam cov qog loj hlob (tejzaum nws cuam tshuam nrog cov piam thaj metabolism).

Kev Sib Tw: Kev tshawb fawb ntxiv yog xav tau ntawm tib neeg kev ua tau zoo, kev siv tshuaj zoo, thiab kev xa khoom.

Antifungal/antiparasitic infection adjuvants ??

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Mechanism: Cov kab mob xws li Candida albicans thiab Plasmodium tso siab rau tus tswv tsev mannose receptors los cuam tshuam cov hlwb. Mannose tuaj yeem thaiv nws qhov adhesion.

Kev tshawb fawb:

Hauv vitro thiab tsiaj qauv tau pom tias mannose tuaj yeem inhibit Candida adhesion rau cov hlwb epithelial.

Kev siv ua ke nrog cov tshuaj tiv thaiv kab mob tuaj yeem txo qhov kis tus kab mob malaria parasites (kev sim tsiaj txhu).

Muaj Peev Xwm: Ua ib qho kev txhawb nqa los txhim kho kev ua tau zoo ntawm cov tshuaj tiv thaiv kab mob uas twb muaj lawm thiab txo cov tshuaj tiv thaiv.

3 、 Cov lus qhia kev tshawb nrhiav tshiab (muaj peev xwm txheeb xyuas tau)

Inflammatory bowel disease (IBD) thiab kho lub plab zom mov ??

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Kev xav:

Mannose tuaj yeem tswj cov plab hnyuv microbiota (txhawb cov kab mob uas muaj txiaj ntsig) thiab tiv thaiv kab mob kab mob adhesion.

Txhim khu kev ua haujlwm ntawm plab hnyuv mucosal barrier proteins los ntawm kev hloov kho glycosylation.

Cov xwm txheej tam sim no: Tsiaj qauv (colitis) qhia qee yam kev tiv thaiv, tab sis tib neeg kev tshawb fawb tsis muaj.

Kev tswj cov kab mob autoimmune ??

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Txoj kev xav: Qhov txawv txav glycosylation yog koom nrog hauv cov kab mob rheumatoid mob caj dab, lupus, thiab lwm yam kab mob. Mannose supplementation tuaj yeem kho glycosylation tsis xws luag.

Kev nce qib: Tsuas yog pom hauv cov qauv ntawm tes lossis cov neeg mob tsawg heev, tsis muaj kev sim tshuaj nruj heev.

Kev tiv thaiv cov teeb meem ntawm ntshav qab zib ??

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Logic: Cov ntshav qab zib siab ua rau ntau dhau uas tsis yog enzymatic glycation (AGEs) ntawm cov protein, ua rau muaj teeb meem. Mannose metabolism tsis yog nyob ntawm insulin thiab tsis cuam tshuam rau cov ntshav qabzib, lossis nws tuaj yeem txo qis kev tsim ntawm AGEs.

Cov ntaub ntawv pov thawj: Tsiaj thwmsim qhia tias kev nce qib ntawm ntshav qab zib nephropathy tau qeeb, thiab tib neeg kev tshawb fawb tsis muaj dab tsi.

4 、 Kev sib tw thiab kev txwv

Cov kev sib tw tseem ceeb hauv thaj chaw

Kev tiv thaiv UTI tsis zoo tiv thaiv cov kab mob uas tsis yog Escherichia coli; Cov ntaub ntawv kev nyab xeeb mus sij hawm ntev tsis txaus (tshwj xeeb tshaj yog lub raum ua haujlwm cuam tshuam)

Kev kho CDG tsuas yog siv tau rau cov subtypes tshwj xeeb; Yuav tsum tau kuaj xyuas ntxov thiab tshuaj noj mus ntev

Qhov ua tau zoo ntawm kev kho mob qog hauv tib neeg lub cev tsis paub; Cov koob tshuaj ntau yuav ua rau raws plab; Qhov kev pheej hmoo toxicity ntawm combining chemotherapy yuav tsum tau soj ntsuam

Kev siv tsis txaus ntawm kev siv ib leeg los tiv thaiv kab mob adjuvants; Yuav tsum tau ua kom zoo rau kev kho ua ke nrog cov tshuaj uas twb muaj lawm

Kev tshawb fawb tsis muaj zog ntawm cov txheej txheem hauv lwm qhov chaw tshiab; Tsis muaj kev sim tshuaj ntsuam xyuas zoo; Lawv feem ntau tseem nyob hauv cov tsiaj qauv theem

5 、 Txoj kev txhim kho yav tom ntej

Precision delivery system development: Tsim mannose modified nanocarriers los txhim kho qog / kis kab mob hom phiaj.

Combination therapy optimization: tshawb xyuas cov teebmeem ntawm mannose nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob tiv thaiv kab mob, thiab tshuaj tua kab mob.

Tsis tshua muaj kab mob nthuav dav: Kev tshuaj xyuas ntau dua CDG subtypes thiab lysosomal cia mob uas tuaj yeem kho nrog mannose.

Kev ua yeeb yam ntev-tso tawm qauv: daws teeb meem ntawm cov tshuaj nquag (xws li kev siv txhua hnub rau kev tiv thaiv UTI).

Population stratification lub tswv yim: precision tshuaj raws li hom kab mob (UTI) lossis noob hloov pauv (CDG)