Vitamin B3, tseem hu ua niacin, yog ib qho dej-soluble vitamin uas ua tau ntau yam tseem ceeb ntawm lub cev muaj zog hauv lub cev. Cov kev tshawb fawb thaum ntxov tau pom tias vitamin B3 koom nrog hauv lub cev lub zog metabolism hauv cov txheej txheem, txhawb cov metabolism hauv cov tawv nqaij, thiab tseem muaj qee yam antioxidant.

Cov kab mob uas tsis yog-alcoholic fatty siab (NAFLD), yog qhov tshwm sim siab tshaj plaws ntawm cov kab mob siab ntev hauv Suav teb, muaj ntau dua 150 lab tus neeg mob hauv Suav teb, ntawm 10-20% yuav txuas ntxiv mus rau cov kab mob uas tsis yog-alcoholic steatohepatitis (NASH), feem ntau tshwm sim los ntawm o thiab daim siab cell puas, feem ntau nrog fibrosis. NASH vam meej sai thiab muaj kev pheej hmoo siab ntawm kev tsim cov kab mob siab loj xws li cirrhosis thiab mob qog noj ntshav siab.

Tsis ntev los no, Cov kws tshawb fawb los ntawm Lub Tsev Kawm Ntawv Kev Noj Qab Haus Huv ntawm Sun Yat-sen University tau luam tawm ib daim ntawv nyob rau hauv phau ntawv journal JAMA Network Open hu ua "Kev noj haus Niacin noj thiab kev tuag ntawm cov tib neeg uas tsis muaj cawv. Fatty Liver Disease" daim ntawv tshawb fawb.

Txoj kev tshawb no qhia tau hais tias ntxiv nrog cov vitamin B3, los yog txo qhov kev pheej hmoo ntawm tag nrho cov-ua rau tuag nyob rau hauv cov neeg mob uas tsis yog-coholic fatty daim siab kab mob, yog txuam nrog 30% txo qhov kev pheej hmoo ntawm tag nrho cov-ua rau tuag rau cov neeg koom nrog ntau tshaj (≥26.7mg / hnub) piv nrog cov neeg koom nrog qhov tsawg tshaj plaws noj (≤18.4mg / hnub).

Hauv txoj kev tshawb no, cov kws tshawb nrhiav tau txheeb xyuas qhov sib koom ntawm kev noj zaub mov vitamin B3 thiab qhov kev pheej hmoo ntawm txhua qhov ua rau tuag rau cov neeg mob uas tsis muaj ntshav qab zib hauv lub siab los ntawm kev sau cov vitamin B3 kom tsawg los ntawm National Health and Nutrition Examination Survey (NHANES) database ntawm 4,315 NAFLD cov neeg mob uas muaj hnub nyoog nruab nrab ntawm 53 xyoo.

Cov neeg koom nrog tau muab faib ua peb pawg raws li kev noj cov vitamin B3: pab pawg tsawg tsawg (≤18.4mg / hnub), pab pawg noj nruab nrab (18.5-26.6mg / hnub) thiab pab pawg kom tau txais siab (≥26.7mg / hnub).
Thaum lub sij hawm nruab nrab ntawm kev soj ntsuam ntawm 8.8 xyoo, tag nrho ntawm 566 tus neeg tuag tau sau tseg, 197 tus neeg raug ntaus nqi los ntawm cov kab mob plawv.

Kev tshuaj xyuas pom tau tias cov neeg koom nrog kev noj haus ntau tshaj plaws muaj 30 feem pua ????tsawg dua kev pheej hmoo ntawm kev tuag tag nrho piv rau cov neeg koom nrog kev noj tsawg tshaj plaws.

Tsis tas li ntawd, cov neeg koom nrog kev noj haus ntau tshaj plaws tau txo qis 35 feem pua ????ntawm cov kab mob plawv, tab sis qhov no tsis yog qhov tseem ceeb.

Kev soj ntsuam ntxiv pom muaj kev cuam tshuam tseem ceeb ntawm kev noj cov vitamin B3 thiab kev pheej hmoo ntawm ntshav qab zib thiab txhua yam ua rau tuag, nrog kev txo qis hauv kev tuag ntau dua hauv cov neeg mob uas tsis muaj ntshav qab zib piv rau cov neeg mob ntshav qab zib.

Raws li cov kws tshawb fawb, niacin yog ib qho ntawm cov precursors ntawm NAD synthesis thiab tau dhau los ua lub hom phiaj tseem ceeb rau kev tiv thaiv thiab kho kab mob siab. Cov kev tshawb fawb txog pej xeem kuj tau pom tias niacin tuaj yeem txhim kho daim siab rog thiab txo cov rog hauv siab. Hauv kev tshawb fawb preclinical, niacin tau pom tias inhibit thiab thim rov qab daim siab steatosis thiab o, thiab tiv thaiv fibrosis. Cov teebmeem no tau ua tiav los ntawm kev txo qis oxidative kev nyuaj siab, inhibiting diacylglyceryl acyltransferase 2 thiab NADPH oxidase kev ua, thiab lwm yam ua tau.

Nws tsim nyog hais tias thaum lub Cuaj Hlis 2023, Cov Kws Tshawb Fawb los ntawm Tsev Kawm Ntawv Kev Noj Qab Haus Huv ntawm Sun Yat-sen University tau luam tawm ib daim ntawv hauv phau ntawv xov xwm Nutrients hu ua "Kev Koom Tes ntawm Kev Noj Qab Haus Huv Niacin Intake thiab Nonalcoholic Fatty Liver Disease: NHANES 2003-2018" daim ntawv tshawb fawb.

Txoj kev tshawb no pom tau hais tias kev ntxiv cov vitamin B3 yog txuam nrog kev pheej hmoo ntawm cov kab mob uas tsis yog-coholic fatty siab, nrog rau cov neeg uas muaj niacin ntau tshaj plaws (≥29.2mg / hnub) muaj 31% qis dua kev pheej hmoo ntawm cov kab mob hauv siab tsis muaj cawv piv nrog cov neeg uas muaj niacin tsawg tshaj plaws (≤16.3mg / hnub).

Muab ua ke, cov txiaj ntsig tau qhia tias kev ntxiv cov vitamin B3 yog txuam nrog kev pheej hmoo ntawm cov kab mob uas tsis yog-coholic fatty siab thiab txo kev pheej hmoo ntawm tag nrho cov-ua rau tuag rau cov neeg mob uas muaj cov kab mob nonalcoholic fatty siab. Kev tshawb fawb ntxiv yog xav tau kom paub tseeb tias qhov kev pom zoo ntawm cov tshuaj vitamin B3 kom txo tau txoj kev pheej hmoo ntawm txhua qhov ua rau tuag rau cov neeg mob NAFLD.