Cov kev tshawb fawb thaum ntxov tau pom tias vitamin C muaj ntau yam txiaj ntsig kev noj qab haus huv, suav nrog kev tiv thaiv kab mob, tshuaj tiv thaiv antioxidant, thiab kev noj qab haus huv ntawm lub plawv. Txawm hais tias vitamin C yog ib qho khoom noj tseem ceeb rau kev noj qab haus huv, ntau dhau lossis tsawg dhau tuaj yeem ua rau muaj kev phom sij rau kev noj qab haus huv.

Melanoma (MM) yog cov qog qog nqaij hlav uas tshwm sim hauv cov hlwb pigmented ntawm daim tawv nqaij thiab yog hom mob qog noj ntshav txaus ntshai tshaj plaws, txawm hais tias nws muaj qhov tshwm sim tsawg thiab muaj kev txhoj puab heev thiab metastatic. Qhov xwm txheej ntawm melanoma tau nce ntxiv nyob rau ob peb xyoos dhau los.

Tsis ntev los no, Cov kws tshawb fawb los ntawm University of South Florida hauv Tebchaws Meskas thiab University of Leicester hauv tebchaws United Kingdom tau luam tawm ib daim ntawv hu ua "Redox modulation of oxidatively-induced DNA damage by ascorbate enhances" nyob rau hauv phau ntawv journal Free Radical Biology and Medicine ob leeg hauv vitro thiab ex-vivo DNA puas tsim thiab cell tuag hauv melanoma hlwb ".

Cov kev tshawb fawb tau pom tias kev kho mob qog noj ntshav melanoma nrog cov vitamin C tuaj yeem ua rau oxidant-induced DNA puas tsuaj rau cov qog nqaij hlav cancer thiab txhawb cov qog nqaij hlav cancer tuag, thiab qhov kev puas tsuaj no yog proportional rau tus nqi melanin hauv cov hlwb. Thiab rau cov tawv nqaij ib txwm muaj, nws ua lub luag haujlwm tiv thaiv.

Hauv txoj kev tshawb no, cov kws tshawb fawb tau tsim ib pab pawg ntawm MM cell kab nrog cov pigmentation sib txawv, siv hydrogen peroxide ua tus qauv oxidant, thiab tshuaj xyuas vitamin C kom nce qhov tshwm sim ntawm melanoma cell tua los ntawm kev txhim kho oxidation-induced DNA puas.

Cov kws tshawb fawb tau sim qib ntawm vitamin C-vim DNA puas tsuaj hauv tsib kab ntawm tes thiab pom tias piv nrog cov tawv nqaij ib txwm muaj, keratinocytes (HaCaT), qib ntawm endogenous DNA puas feem ntau siab dua nyob rau hauv tag nrho cov MM hlwb, nyob rau hauv kev txiav txim ntawm kev puas tsuaj loj: SK23 hlwb nrog pigmentation siab, SK28 hlwb nrog nruab nrab pigmentation, A375MP hlwb tsis muaj pigmentation, A375MP thiab A375MP. degree ntawm DNA puas.

Tsis tas li ntawd, cov kws tshawb fawb tau soj ntsuam qhov rhiab heev ntawm tsib kab xov tooj ntawm tes rau kev puas tsuaj los ntawm oxidant (hydrogen peroxide) thiab pom tias qhov kev puas tsuaj rau hydrogen peroxide yog raws li cov saum toj no.

Kev soj ntsuam ntxiv ntawm cov kab mob oxidative intracellular pom tau tias MM hlwb nthuav tawm ntau cov kab mob endogenous ntawm cov kab mob oxidative ntau dua li HaCaT hlwb, thiab kev sib txuas ntawm tsib kab ntawm tes tau zoo ib yam nrog DNA puas, kev puas tsuaj rhiab heev, thiab cytopigmentation.

Tom ntej no, cov kws tshawb fawb tau kho cov hlwb nrog lossis tsis muaj vitamin C thiab tshuaj xyuas qhov muaj peev xwm tswj hwm cov vitamin C ntawm oxidation-induced DNA puas tsim thiab tua cell.

Cov txiaj ntsig tau pom tias rau txhua lub hlwb MM, qib ntawm endogenous DNA puas tsuaj los ntawm kev kho mob vitamin C tau nce ntxiv, thaum lub hlwb HaCaT tsis tseem ceeb, thiab kev puas tsuaj rau endogenous DNA tau ua raws li cov saum toj no.

Tsis tas li ntawd, qib ntawm vitamin C-induced nucleobase kev puas tsuaj yog siab tshaj nyob rau hauv cov pigmented SK23 hlwb (18.5%) thiab qis tshaj nyob rau hauv non-pigmented A375P hlwb (14.2%).

Raws li qhov tseeb tias vitamin C tuaj yeem txhim kho peroxide induced endogenous DNA puas thiab nucleobase puas nyob rau hauv MM hlwb, cov kws tshawb fawb kuj soj ntsuam cov nyhuv ntawm vitamin C ntawm DNA ob strand so thiab pom tias rau tag nrho cov MM hlwb, theem ntawm DNA ob strand so induced los ntawm kev kho vitamin C nce ho, tab sis tsis yog rau HaCaT hlwb. Qhov sib lawv liag ntawm tsib kab ntawm tes tseem ua raws li cov saum toj no.

Qhov tseem ceeb, cov kws tshawb fawb tau soj ntsuam seb cov vitamin C txhim kho peroxid-induced MM cell tuag, thiab pom tias vitamin C txhim kho peroxid-induced tua ntawm tag nrho cov MM hlwb, thaum ua si lub luag hauj lwm tiv thaiv nyob rau hauv HaCaT hlwb, thiab kev tua kab mob raws li cov saum toj no.

Thaum kawg, txoj kev tshawb fawb kuj pom tias vitamin C tuaj yeem txhim kho qhov ua tau zoo ntawm cov tshuaj melanoma uas twb muaj lawm Elesclomol, txhim kho DNA kev puas tsuaj ntawm cov qog nqaij hlav los ntawm Elesclomol.

Cov kws tshawb fawb tau hais tias kev siv cov vitamin C, uas tuaj yeem ua rau DNA puas tsuaj hauv cov qog nqaij hlav cancer thiab ua rau cov qog nqaij hlav cancer tuag, yuav yog ib txoj hauv kev zoo dua los kho melanoma, uas tseem xav tau kev tshawb fawb thiab kev sim ntau ntxiv los xyuas.

Muab hais tias cov vitamin C tau kawm tau zoo thiab paub tias muaj kev zam zoo, cov kws tshawb fawb ntseeg tias cov kws kho mob tuaj yeem siv cov vitamin C ntxiv los txhim kho cov kev kho mob uas twb muaj lawm.

Ua ke, qhov kev tshawb fawb hauv vitro qhia tau tiasvitamin Ctuaj yeem txhim kho oxidation-induced endogenous DNA puas tsuaj, txhawb kev mob qog noj ntshav cell tuag, thaum ua lub luag haujlwm tiv thaiv hauv cov tawv nqaij ib txwm muaj, thiab txhim kho cov txiaj ntsig ntawm cov tshuaj melanoma uas twb muaj lawm, uas tsim nyog rau kev kawm ntxiv.