Prostate cancer (PC), ib qho ntawm cov qog nqaij hlav ntau tshaj plaws hauv cov txiv neej, zoo li tus neeg tua neeg uas ntsiag to, nrog cov neeg mob feem ntau ntsib cov tsos mob qeeb qeeb ntawm tus kab mob uas tuaj yeem ua rau mob qog noj ntshav. Thaum lub sijhawm ntawd, mob qog noj ntshav prostate tuaj yeem dhau los ua qhov tsis txaus ntseeg uas txhua yam kev kho mob muaj tsis teb rau nws.

Raws li cov lus hais mus, kev kho mob nyob ntawm "peb lub ntsiab lus ntawm cov tshuaj, xya lub ntsiab lus ntawm kev saib xyuas", qhov "kev tu" feem ntau yog hais txog cov khoom noj tonic. Prostate cancer yog ib yam kab mob mus ntev. Yog tias tsim nyog txoj kev cuam tshuam, xws li kev ua neej tsim nyog thiab kev noj haus, tuaj yeem raug coj mus rau theem pib ntawm tus kab mob, nws tuaj yeem ncua kev mob qog noj ntshav prostate thiab txhim kho cov neeg mob.

Thaum Lub Kaum Hli 25, 2024, pab pawg ntawm xibfwb Lloyd Trotman ntawm Cold Spring Harbor Laboratory tau luam tawm nyob rau hauv cov ntawv xov xwm thoob ntiaj teb kev kawm Science txoj cai: Kev noj haus pro-oxidant kho los ntawm vitamin K precursor lub hom phiaj PI 3-kinase VPS34 muaj nuj nqi Kev tshawb fawb daim ntawv.

Cov kev tshawb fawb tau pom tias cov tshuaj tiv thaiv oxidant ntxiv, menadione (vitamin K3), tuaj yeem ua rau qeeb ntawm kev mob qog noj ntshav prostate. Menadione yog cov dej-soluble precursor ntawm vitamin K, uas feem ntau pom muaj nyob rau hauv ntsuab nplooj zaub, thiab nws physiological muaj nuj nqi yog tsuas yog txhawb cov ntshav txhaws thiab koom nyob rau hauv cov pob txha metabolism.

Cov kev tshawb fawb tshuab tau pom tias VPS34 yog lub hom phiaj tseem ceeb ntawm phosphatidylinositol 3-kinase (PI3K), menadione tuaj yeem cuam tshuam cov haujlwm ntawm VPS34, txo qis kev tsim tawm ntawm PI3P, thiab ua rau muaj kev ntxhov siab oxidative ua rau kev tuag ntawm prostate cancer hlwb. Hauv qhov sib piv, cov hlwb ib txwm loj hlob qeeb thiab yog li muaj lub zog txaus los tiv thaiv qhov kev puas tsuaj no. Tsis tas li ntawd, pab pawg tshawb fawb tau pom tias menadione kuj muaj kev kho mob hauv kev mob caj dab tuag hu ua X-linked myotubulin myopathy (XLMTM).

Cov kev tshawb pom no qhia txog txoj hauv kev yooj yim tab sis muaj txiaj ntsig zoo los cuam tshuam kev mob qog noj ntshav thiab muaj qhov cuam tshuam tshiab rau kev kho mob ntawm lwm cov kab mob caj ces los ntawm kev ua haujlwm tsis zoo ntawm kinase.

Pab neeg no kho RapidCaP nas qauv nrog cov tshuaj tiv thaiv oxidant, menadione sodium sulfite (MSB), ib qho chaw uas yog cov tsiaj txhu ua ntej rau cov vitamin K. Lawv pom tias ib hnub ntxiv ntawm MSB hauv dej haus tuaj yeem cuam tshuam kev mob qog noj ntshav prostate thiab tsim cov nyhuv inhibitory ntev.

Zuag qhia tag nrho, txoj kev tshawb fawb, luam tawm hauv Science, qhia tias ntxiv cov tshuaj tiv thaiv oxidant rau kev noj zaub mov kom ntxiv MSB tuaj yeem cuam tshuam cov kab mob ntawm kev mob qog noj ntshav prostate. Qhov no yog vim hais tias MSB tuaj yeem cuam tshuam cov kev ua ntawm PI3K kinase VPS34, txo qhov tsim ntawm PI3P, thiab nce oxidative kev nyuaj siab, uas ua rau kev tuag ntawm prostate cancer hlwb. Tsis tas li ntawd, hauv X-txuas myotubular myopathy (XLMTM), MSB tuaj yeem cuam tshuam kinase kev ua ntawm VPS34, rov ua kom PI3P rau qib uas tuaj yeem txhim kho cov leeg nqaij.