Hauv kev tshawb nrhiav kev noj qab haus huv hauv plab, Polydextrose tau ntev tau muab cais ua cov dej-soluble noj fiber ntau. Txawm li cas los xij, ntau txoj kev tshawb fawb nyob rau xyoo tas los no tau pom tias cov khoom siv hluavtaws no randomly polymerized los ntawm cov piam thaj yog qhov "ntau yam neeg uas ua ntawv" uas rov ua dua lub plab hnyuv microecology los ntawm triple mechanism ntawm "dynamic viscosity regulation - precise feeding of microbiota - metabolite cascade reaction". Txoj kev tshawb fawb tshiab hauv Nature Gastroenterology hauv xyoo 2024 qhia tias kev noj txhua hnub ntawm 10-15g ntawm polyglucose tuaj yeem txhim kho kev ncaj ncees ntawm txoj hnyuv los ntawm 37% thiab txo qis qib ntawm IL-6 los ntawm 29%. Qhov kev tshawb pom no tsis tsuas yog cuam tshuam cov kev paub ib txwm muaj tab sis kuj tseem ua rau muaj kev cuam tshuam rau kev qhuab qhia kev siv nthwv dej xws li kev lag luam zaub mov mus rau cov tshuaj kho mob.

?

Youdaoplaceholder0 Tshooj 1 Kev Tshaj Tawm Txog Kev Tshawb Fawb: "Tag Nrho Cov Kev Txawj Ntse" ntawm cov molecule

Youdaoplaceholder0 1.1 Viscosity deformation: "cov lus teb ntse" los ntawm plab mus rau txoj hnyuv

Lub uniqueness ntawm polydextrose nyob rau hauv nws Ph-responsive viscosity hloov:

?

Youdaoplaceholder0 Lub plab (pH 1.5-3.0): Molecular chains yog cross-linked los ntawm hydrogen bonds los tsim ib tug peb-dimensional network qauv, viscosity soaps mus txog 1500 mPa·s, slows down gastric emptying tus nqi mus txog rau 45% (piv nrog rau cov khoom noj khoom haus zoo tib yam 20% satiety);

Youdaoplaceholder0 Cov hnyuv me (pH 6.0-7.4): Hydrogen bonds yog ib feem tawg, viscosity raug txo mus rau 400 mPa·s, thiab kua tsib acid adsorption txo cov roj cholesterol nqus los ntawm 18% yam tsis muaj kev cuam tshuam rau kev nqus cov as-ham;

Youdaoplaceholder0 Colon ?(pH 7.0-7.5): Microbial fermentation yog pib, viscosity disintegrates rau qis dua 50 mPa·s, short-chain fatty acids (SCFAs) raug tso tawm, nrog butyric acid concentration nce 3.2 zaug, ncaj qha activating plab hnyuv epithelial cell (1).

Youdaoplaceholder0 Technology Breakthrough : DSM's SmartVisc? thev naus laus zis tuaj yeem kho cov viscosity nkhaus rau cov ntu sib txawv los ntawm kev tswj cov qib ntawm polymerization (DP tus nqi), xws li G-hom mis tsim tshwj xeeb rau cov neeg mob gastroesophageal reflux, uas ua rau lub cev tiv thaiv zaj duab xis nrog lub plab viscosity txog li 20 mPa.

?

Youdaoplaceholder0 1.2 Txoj Cai Microbiota: Los ntawm "kev pub noj dav dav" mus rau "cov phiaj xwm nce"

Traditional prebiotics feem ntau indiscriminately txhawb tag nrho cov microbiota, thaum polydextrose qhia meej meej muaj peev xwm:

?

Youdaoplaceholder0 Upstream inhibition : Lub xeev siab viscosity tsim ib qho kev thaiv lub cev nyob rau hauv txoj hnyuv loj, inhibiting adhesion ntawm cov kab mob pathogenic (xws li Escherichia coli), txo cov kab mob colonization ntawm 52%;

Youdaoplaceholder0 Downstream proliferation : Oligosaccharide fragments tau nyiam siv los ntawm cov kab mob uas muaj txiaj ntsig zoo xws li Bifidobacterium thiab Roseella, thiab lawv cov kev nplua nuj tau nce li 68% tom qab 8 lub lis piam ntawm kev cuam tshuam (raws li metagenomic sequencing);

Youdaoplaceholder0 Metabolic synergy : Butyric acid tsim ua rau lub GPR109A receptor, induces kev tswj T cell sib txawv, thiab optimizes plab hnyuv siab npaum li cas Performance index rau 0.91 (kev noj qab haus huv pib> 0.85).

Youdaoplaceholder0 Tshooj 2 Daim ntawv thov cua daj cua dub: Kev xyaum hla ciam teb los ntawm lub rooj mus rau lub txaj pw hauv tsev kho mob

Youdaoplaceholder0 2.1 Kev Lag Luam Khoom Noj: Lub "tsis pom lub cav" nrog cov haujlwm hloov kho

Youdaoplaceholder0 Baking Revolution ?: Lub Meiji Group ntawm Nyiv Pooj tau tsim cov ncuav qab zib xoom-sucrose los ntawm kev ua kom zoo dua ntawm cov dej tuav (8.3g dej / g) thiab thermal stability (siab ntev rau 220 ° C) ntawm polyglucose, txo cov ntshav qabzib tom qab hloov pauv los ntawm 41%.

Youdaoplaceholder0 Beverage Innovation ? : Nongfu Spring's Intestinal Sparkling Water, uas siv cov colonic fermentation gas-produced property of polyglucose to relieve constipation without irritation, muag tshaj 8 lab fwj hauv thawj lub hlis ntawm kev ua lag luam;

Youdaoplaceholder0 Kev hloov pauv zaub mov: Soylent hauv Teb Chaws Asmeskas siv cov qauv viscosity-gradient los txuas lub zog qeeb-tso ncua mus txog 6 teev thiab txhim kho qhov kev ua siab ntev ntawm cov neeg sib tw marathon los ntawm 23%.

Youdaoplaceholder0 2.2 Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv: "Cov kab mob hauv plab hnyuv" rau cov neeg mob ICU

Txoj kev tshawb RCT ntawm Sir Run Run Shaw Tsev Kho Mob, Tsev Kawm Ntawv Tshuaj, Zhejiang University (n=204) qhia tias:

?

Youdaoplaceholder0 Kev Tiv Thaiv Kab Mob : Hauv ICU cov neeg mob ntxiv nrog 15g ntawm polydextrose txhua hnub, qhov tshwm sim ntawm enterogenous sepsis txo los ntawm 44%;

Youdaoplaceholder0 Mucosal kho : Plasma ligonin (ib qho cim ntawm plab hnyuv permeability) qib txo qis los ntawm 31% thiab goblet cell ceev nce 39%;

Youdaoplaceholder0 Immunomodulatory ?: Serum IgA concentration nce 28%, thiab CD4 + / CD8 + T cell ratio rov qab mus rau qhov qub.

Youdaoplaceholder0 Tshooj 3 Txoj Kev Hloov Kho Tshuab: Los Ntawm Kev Tsim Qauv Molecular rau AI-Enabled Precision Nutrition

Youdaoplaceholder0 3.1 Kev hloov kho qauv: Xauv Customization ntawm kev thov

Youdaoplaceholder0 Targeted viscosity ?: Los ntawm kev qhia txog sorbitol sab chains, txoj hnyuv tshwj xeeb disintegrating polyglucose (hom C) tau tsim, uas nws cov viscosity poob qis mus rau 10 mPa·s ntawm pH 7.0, tshwj xeeb tshaj yog rau cov neeg cem quav;

Youdaoplaceholder0 Txhim kho kab lis kev cai : Roguet, Fabkis, tsim Probiocoat ? microcapsule thev naus laus zis uas encapsulates probiotics hauv polyglucose matrix, nce gastric acid ciaj sia ntawm 15% mus rau 92%.

Youdaoplaceholder0 3.2 Artificial INTELLIGENCE: Cracking the Code of Personalized intervention

Lub "Digital Twin of the Intestine" system tsim los ntawm NutriAI, lub tuam txhab Israeli, koom ua ke 200,000 tus neeg mob cov ntaub ntawv hauv plab hnyuv thiab cov kua dej dynamics, uas tuaj yeem kwv yees tus neeg teb cov lus teb rau polydextrose:

?

Youdaoplaceholder0 Dose optimization : Lub 8-12g / hnub + fructooligosaccharide ua ke kev tswj hwm pom zoo rau cov neeg mob IBS txo qhov tshwm sim ntawm plab hnyuv los ntawm 67%;

Youdaoplaceholder0 Scene haum : Ib qho kev tawm dag zog siab ua kom haum rau cov neeg ncaws pob, uas ua rau cov colonic fermentation nce mus txog 40% thiab zam kev tsis xis nyob hauv plab thaum kawm.

Youdaoplaceholder0\n\n Tshooj Plaub: Kev Lag Luam Kev Lag Luam: Lub Tshuab Kev Sib Tw Hauv Kev Lag Luam Trillion-dollar

Youdaoplaceholder0 4.1 Kev Sib Tw Muaj Peev Xwm: Cov tuam txhab suav suav hla ntawm qhov nkhaus

Youdaoplaceholder0 Baolingbao Bio ??: Peev 800 lab yuan los tsim lub ntiaj teb qhov loj tshaj plaws polyglucose ntau lawm puag, enzymatic synthesis technology kom tiav 99.9% purity;

Youdaoplaceholder0 Hualixi Biotech ?: Tsim cov nano-fibrotic polyglucose, viscosity regulation rhiab heev los ntawm 4 npaug, tau txais NMPA Tshwj Xeeb Kev Kho Mob zaub mov pom zoo;

Youdaoplaceholder0 Transnational layout ?: DuPont tab tom koom tes nrog Mayo Clinic txhawm rau nce qib III kev soj ntsuam kuaj ntawm polydextrose hauv kev tiv thaiv kab mob qog noj ntshav.

Youdaoplaceholder0 4.2 Kev Paub Txog Kev Nyuaj Siab: Qhov sib txawv ntawm lub Lab mus rau Kev Lag Luam Loj

Txawm hais tias muaj pov thawj scientific txaus, kev tshawb fawb ntawm cov neeg siv khoom pom tau tias:

?

Youdaoplaceholder0 Kev Paub Qhov Muag Qhov Muag : Tsuas yog 31% ntawm cov pej xeem nkag siab txog kev ua haujlwm sib txawv ntawm polydextrose thiab cov fibers ntau;

Youdaoplaceholder0 Dose misconceptions : 45% ntawm cov neeg siv khoom yuam kev ntseeg tias "ntau dua yog qhov zoo dua", uas yuav ua rau tsis xis nyob xws li tsam plab;

Youdaoplaceholder0 Kev Lag Luam Teb : Lub Koom Haum Noj Qab Haus Huv Suav tau tshaj tawm Daim Ntawv Dawb ntawm Daim Ntawv Thov Polydextrose, teeb tsa kev nyab xeeb ntawm 15g ib hnub.

Youdaoplaceholder0 Tshooj 5 Lub Zeem Muag Yav Tom Ntej: Rov txhais Fibre's 'Smart Boundary'

Youdaoplaceholder0 5.1 Brain-Gut Axis Breakthrough: Ib Tug Choj Molecular ntawm lub plab mus rau Kev Xav

Cov kev sim tsiaj tshiab kawg ntawm California Institute of Technology tau pom:

?

Youdaoplaceholder0 Kev ntxhov siab ntxhov siab : Cov nas nyob rau hauv pawg pab pawg cuam tshuam polyglucose tau nce lawv lub sijhawm tshawb nrhiav hauv qhov kev sim maze los ntawm 53%;

Youdaoplaceholder0 Mechanism tracing : Butyric acid activates BDNF qhia nyob rau hauv hippocampus los ntawm cov ntshav-hlwb barrier, nce synaptic ceev los ntawm 29%.

Youdaoplaceholder0 5.2 Synthetic Biology: 'Ultimate Form' ntawm programmed fibers

Lub tuam txhab Ginkgo Bioworks hauv Tebchaws Meskas tau hloov kho cov kab mob poov xab siv CRISPR-Cas9 thev naus laus zis los tso ncaj qha "gene-encoded polydextrose" nrog cov haujlwm ua haujlwm:

?

Youdaoplaceholder0 Lub hom phiaj meej : Nws tuaj yeem txhawb kev loj hlob ntawm Achaemenia, thiab nws qhov kev nplua nuj tau nce los ntawm 80% hauv cov qauv rog;

Youdaoplaceholder0 Cov lus teb ntse : Built-in pH sensor, viscosity hloov qhov tseeb tau txhim kho mus rau ± 5 mPa·s, xav tias yuav nkag mus rau kev sim tshuaj hauv 2026.

Youdaoplaceholder0 Xaus: Thaum molecular Intelligence ntsib Gut Ecology

Txoj kev taug kev ntawm polydextrose yog keeb kwm ntawm kev rov qab los ntawm "kev lag luam los ntawm cov khoom" mus rau "tus kws kho mob plab hnyuv". Nws qhia peb tias qhov tseeb ntawm kev noj qab haus huv feem ntau tshwm sim los ntawm kev sib sib zog nqus deconstruction thiab hla ciam teb reorganization ntawm lub ntsiab ntawm cov teeb meem. Ib yam li Nobel laureate Jennifer Doudna tau hais tias, "Synthetic biology qhia peb tias molecules tuaj yeem muaj txiaj ntsig nrog 'lub peev xwm xav'." Hauv qhov kev hloov kho thev naus laus zis no ntawm kev noj qab haus huv ntawm plab hnyuv, polydextrose yuav tsuas yog qhov pib - thaum ntau "ntse molecules" koom nrog kev sib ntaus sib tua, tib neeg yuav ua tiav qhov tseeb tiv thaiv kab mob.