N'okike, mannose d? na ?n?d? efu na ?f?d? mkp?r? osisi, d? ka cranberries, apples, oranges, wdg. N'ime ah? mmad?, mannose na-ekesa n'an? ah? na ?bara niile, g?nyere akp?kp? ah?, ak?k? ah? na irighiri akwara. N'ime an? ah? nd? a, mannose na-etinye aka na njik? nke glycoproteins nke na-ach?kwa ?r? nke sistemu autoimmune. Nnyocha ?l? ?gw? gara aga egosila na mannose nwere ike ?gw? ma gbochie ?r?a urinary tract, ya mere a na-eji ?f?d? ngwaah?a ah?ike mba ?z? nwere mannose d? ka isi ihe na-eme ka ah? ike na usoro mmam?r?.

? d?la anya a mara na etuto ah? nwere ?ch?ch? d? elu maka glucose kar?a an? ah? nk?t?. Mkp?r? nd? Tumor nwere ike were glucose ihe ruru okpukpu 10 kar?a sel nk?t? ma dabere kar?a na glycolysis maka ume iji kwado uto ha ngwa ngwa. Otú ? d?, ?b?r? "sugar d? ka nd?", na ihu mannose, ma ?n?d? d? iche mere. N'af? 2018, akw?kw? ak?k? Nature bip?tara nch?p?ta mgbochi nke Cancer Research UK na mannose nwere ike igbochi etuto ah?. Nd? nch?p?ta ah? ch?p?tara na mgbe mannose banyere n’ime mkp?r? nd? tumo, ? na-agbak?ba n’ime mkp?r? nd? n’?d? mannose 6-phosphate, na-egbochi isi iyi ike nke etuto ah? site n’itinye aka na glucose metabolism, si otú ah? na-egbochi uto mkp?r? nd? tumor. Iji kwado nkwubi okwu a, nd? nch?p?ta mere nyocha ?z? na ?d? akp? òké, ha gbakwunyere mannose na mmiri ????? nke ?m? oke "cancer" nd? a, ma nyochaa mmet?ta nke mannose ?n? na ?gw?gw? ?d? ?r?a cancer d? iche iche d? ka ?r?a cancer pancreatic na ?r?a cancer akpa ume na ?m? oke. Nsonaaz? gosiri na nch?kwa ?n? nke mannose site n'??? mmiri na-egbu oge uto tumor na ?m? oke. Mgbe ha kwup?tachara mmet?ta ?gw?gw? nke mannose na ?d? ?b?r? òké, nd? nch?p?ta ah? t?lere inye mannose na ?m? oke na mgbakwunye na chemotherapy maka ?gw?gw? adjuvant, ? t?r? ha n'anya ?h? na mannose na-eme ka ?gw?gw? ?gw?gw? chemotherapy d?kwuo mma, ? b?gh? nan? na-ebelata ?da tumor na ?m? oke, kamakwa na-agbat? ogologo oge nd? "cs". N'af? a, nd? otu nyocha Mahadum Fudan ch?tara ?z? ?h?r? nke mannose anti-cancer - na-ach?kwa molecule checkpoint PD-L1. Kedu ihe b? ebe a na-enyocha mgbochi ?r?a tumor? Any? maara na mgbe ah? nd? mba ?z? d? ka nje bacteria na nje nd? d? n'èzí wakporo ma ? b? mkp?r? nd? nd? d? n'ime ah? nw?r? ma ? b? gh?? ?r?a cancer, ?r? ah? na-al?so ?r?a ?g? ga-ar? ?r?, usoro ah? ji al?so ?r?a ?g? ga-ekerekwa òkè mgbe emechara ya wep? "mkp?r? nd? nd? ?b?a" nd? a. N'otu oge ah?, iji zere imebiga ihe ókè nke usoro ah? ji al?so ?r?a ?g? na "igbu nd? na-enwegh? isi" nke mkp?r? nd? an? ah? nk?t? d? n'ime ah?, e nwere usoro nke "mkp?r? nd? ihe na-enyocha ihe mgbochi" n'ime ah? any?. PD-L1 b? ihe d? mkpa na-enyocha ihe mgbochi na ah? any?, nke nwere ike jik?ta na PD-1 molecule n'elu sel nd? na-al?so ?r?a ?g? ma ziga mgbaàmà "breek" na sel nd? na-al?so ?r?a ?g? iji zere igbu mkp?r? nd? nk?t? site na sel nd? na-al?so ?r?a ?g? (Nyocha 2). Otú ? d?, usoro breeki a d? n'ah? any? na-erigbu site na mkp?r? nd? tumor agh?gh?, na mkp?r? nd? T na microenvironment tumor na-ah? maka igbu etuto ah?, mkp?r? nd? tumor ga-ahap?kwa "brake" akara na mkp?r? nd? T site na ngosip?ta d? elu nke mkp?r? nd? PD-L1, na-egbochi ?r? nke mkp?r? nd? T, iji zere igbu usoro ah? ji al?so ?r?a ?g?.

PD-L1 molecule b? protein bara ?ba na mgbanwe glycosylation. Otu nyocha nke Mahadum Fudan ch?p?tara na mannose nwere ike ibibi nkw?si ike nke protein PD-L1 site n'?ch?kwa glycosylation nke mkp?r? nd? PD-L1, si otú ah? na-akwalite mmebi nke mkp?r? nd? PD-L1. Yab?, mgbe molekul PD-L1 egosip?tara nke ukwuu na mkp?r? nd? etuto na-emebi site na mannose, mkp?r? nd? etuto ah? enwegh? ike ?manye mkp?r? nd? T ka ha “bree”? Nd? nch?p?ta ah? kwadoro echiche ah?: mkp?r? nd? tumor e ji mannose agw? ?r?a nwere ike igbu mkp?r? nd? T; N'ihe at? nke etuto òké, mannose ?n? nwere ike ?kwalite mbuso agha na igbu mkp?r? nd? T na etuto ah? ma gbochie uto nke etuto ah?, yana ngwak?ta nke mannose na ?gw? mgbochi mgbochi mgbochi na-akwalite mbuso agha na igbu mkp?r? nd? T na etuto ah?, ma gbasaa ogologo nd? nke ?m? oke "cancer".

D?ka any? kwuru na mb?, a na-ah? mannose na mkp?r? osisi ?f?d?, ?kachas? kranber? nwere ?d?naya mannose kachas? elu (Njirimara 3). ?t?t? nd? mmad? nwere ike ?n? na-eche, iri cranberries nwere ike igbochi ma ? b? gw?? ?r?a kansa? N'ezie, ntinye nke mannose nyere ?m? oke "cancer" na nyocha ab?? a d? elu ruru 20%, nke p?tara na 100ml ? b?la nke mmiri ????? nwere 20g nke mannose, nke b? nnukwu ntinye na dose. Ya mere, any? na-eri cranberries na nd? ?z? na mkp?r? osisi na-am?ba oriri nke mannose, ruo n'ókè ?f?d?, nwere ike na-akwalite ?g?, conducive na ah? ike, ma ch?r? iji nweta mmet?ta mgbochi cancer cranberries naan? b? nn?? ezuru.