1.1 Site na nr?zi akp?kp? ah? cell ruo n'usoro Cerebrovascular

Ebe ? b? Takeda Pharmaceutical nke Japan mebere Citicoline na 1956, enwere ike were ak?k? ihe mere eme ngwa ya d? ka ak?k? ihe mere eme nke nkwalite ?g?g? isi:

• Af? 1980:A na-eji naan? ya d? ka onye na-ar?zi akp?kp? ah? cell mgbe ?r?a strok gas?r?

• Af? 2010:Ach?p?tara ya na ? nwere ike ?ba ?ba ?bara cerebral (PET-CT gosip?tara mm?ba 23% na mgbawa ?bara nwa oge)

• N'af? 2024,NIH nke United States dep?tara ya d? ka isi ihe na-ach?kwa maka "njik? akwara ozi"

1.2 uto mgbawa nke ah?a zuru ?wa ?n?

Dabere na data nke Evaluate Pharma:

Ire ah?a zuru ?wa ?n? ruru ijeri US $ 4.7 na 2024 (CAGR 12.3%)

Ojiji ?gw? na ?l? ?gw? ihe at? na China abawanyela site na 400% n'ime af? at?

Agbasawanye ihe ngosi na:

?r?a akwara akwara (akara MMSE emelitere site na isi 2.1)

Ah?h? ?b?r? na-akpata ?gba aghara (?n? ?g?g? prognostic GOS m?bara site na 1.5 akara ule)

Isi nke Ab??: Igbe Ojii nke Usoro ?r?

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2.1 ?z? omume at?

Ngosip?ta mmet?ta ebumnuche ebumnuche: Njik? Phosphatidylcholine na-ar?zi iguzosi ike n'ezi ihe nke akp?kp? ah? klaas? I: Acetylcholine precursors na-eme ka nnyefe neurotransmitter Klas IIA: Nitric oxide synthase Regulation na-eme ka microvascular dilation (dayameta na-abawanye site na 18%) Klas IIB

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2.2 Ogologo oge windo ?la edo

Nnyocha 2024 sitere na ?l? ?gw? Njik? Mb? nke Mahadum Sun Yat-sen na-egosi:

?gba ogwu nke 1000mg n'ime 6 awa mgbe ?r?a ?b?r? cerebral nwere ike ?chekwa mpaghara penumbra ischemic site na 7.2cm.3

Agbanyegh?, enwegh? ?d?iche d? ?r?ba ama mgbe nch?kwa ah? gafere awa 72 (p=0.34).

Isi nke At?: Ihe mgbagha nke esemokwu

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3.1 Obi ab?? gbasara ?d? irè

Ntuziaka UK NICE: A na-ewere na ihe akaebe d? ad? ezughi oke iji kwado mkpuchi mkpuchi ah?ike (oke ?n? ah?a ￡ 45,000 / QALY)

Lancet Neurology ** 2025 Meta-Analysis: ? nwegh? nnukwu ?d?iche d? na placebo na otu nh?sianya d? nro (p=0.21)

3.2 ?gbaghara na nkwalite az?mah?a

Ozi 2024 nke National Medical Product Administration:

?l? ?r? iri na ab?? kwusara ihe ngosi ah? (na-akwalite "?gw?gw? adjuvant" d? ka "na-at?ghar? dementia").

Nnwale n'otu ikpo okwu e-az?mah?a na-egosi na ?d?naya nke 32% nke nkwadebe ?n? erugh? 70% nke ego akp?r?.

Isi nke an?: ?ganihu nke tekn?z? tekn?z?

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4.1 Sistem? nnyefe ?gw? ?h?r?

Ihe mgbochi ?b?r? ?b?r? na-abanye peptide gbanwet?r? liposomes (Patent of Peking University Team, CN202410123456.7)

Microneedles na-anabata nkwado (Nnwale an?man? na Seoul National University na South Korea na-egosi mm?ba okpukpu at? na bioavailability)

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4.2 ?gw?gw? nke onwe

Nnyocha nkwonkwo Bgi ach?p?tala na:

Mmet?ta ?gw? nke CDP-cholinesterase gene polymorphic bi (na-ag?ta 31% nke nd? Eshia) abawanyela site na 47%

Isi nke ise Ezi-?wa Data nke nd? ?r?a

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5.1 Okwu nd? ga-erite uru

Ihe ndek? sitere na ?l? ?gw? d? na Hangzhou: Mgbe ?gw?gw? jik?tara ?n?, ikike nchekwa ?bara nke ?b?r? nke onye d? af? 62 nwere ?r?a ?b?r? gbakere na 32% ruo 89%

5.2 Nkwup?ta onwe onye nke otu na-ad?gh? mma

"N'?nara ya ruo ?kara otu af? na-aga n'ihu, ego a na-akw? kwa ?nwa nke yuan 300 kpatara ah? erugh? ala" - ndek? aj?j? ?n? nke Ms. Li, onye ?r?a si Beijing