Nke a b? nyocha na nso nso a, nke e bip?tara na akw?kw? ak?k? a ma ama Nutrients na February 2024, nke Ligia J. Dominguez na nd? ?z? sitere na Mahadum Palermo na Mahadum Enna d? na Italy. Ha nyochachara nke ?ma mmek?r?ta d? n'etiti magnesium na ihe na-egosi ?ka nká na ah? mmad?, wee ch?p?ta na ?nweta a na-ah?kar? nwere ike belata ?n? ?g?g? ?ka nká n'ezie, nke b? ihe ?t?nanya n'ezie!

?

Nd?m?d? nd? isi:

?

1. Magnesium b? nke an? kachas? ?nweta ?nweta n'ime ah? mmad? ma nwee njik? chiri anya na ?r? nke ihe kar?r? 600 enzymes, na-emet?ta usoro d? iche iche nke physiological.

?

2.Magnesium erughi eru b? ihe a na-ah?kar? na nd? agadi, nke met?tara ?t?t? ihe d? ka mkp?r? nd? ihe nketa, gburugburu ebe obibi na nd?. Enweghi oke magnesium n'ime ah? nwere ike ime ka usoro ?ka nká d?kwuo ngwa.

?

3. Nnyocha ach?p?tala na magnesium nwere ike imet?ta 12 isi ihe d? mkpa nke ?ka nká, g?nyere nkw?s? nke genomic, telomere shortening, na epigenetic mgbanwe. A na-at? anya na mgbakwunye magnesium ga-egbu oge ?ka nká ma melite at?manya ah?ike.

?

Nke a b? nch?k?ta zuru ezu nke edemede izizi:

?

Enwegh? Magnesium na-eme ka njirimara ?ka nká 12 d?kwuo elu

?

Enweghi ike nke genomic: Magnesium na-eme ka nhazi nke helix DNA kw?sie ike ma na-etinye aka na usoro nhazi DNA d? iche iche. Enwegh? Magnesium nwere ike ibute mkp?k?ta mmebi DNA, mm?ba mkp?r? nd? ihe nketa, yana ?ka nká ngwa ngwa.

?

Telomere d? mkp?mkp?: Telomeres b? usoro ugboro ugboro na ns?t? chromosomes na-echebe genome p?? na mmebi. Magnesium na-edozi njedebe.

?

Mgbanwe Epigenetic: Mgbanwe Epigenetic na mkp?r? nd? ihe nketa na-eme na-agbanwegh? usoro DNA. Magnesium na-ach?kwa usoro epigenetic d? ka DNA methylation na mgbanwe histone.

?

Protein homeostasis ahagh? nhata: protein njik? na mmebi n'ime cell na-erute nguzozi ike, nke a na-akp? protein homeostasis. Magnesium na-etinye aka n'?hazi proteasome na ?r? lysosome, na ?k? magnesium na-eduga n'?ch?k?ta protein na-ezigh? ezi.

?

?gbaghara nke ngh?ta nri: Insulin / IGF-1 na ?z? mgbaàmà nd? ?z? na-agh?ta ?n?d? nri cellular ma na-ach?kwa metabolism. Magnesium b? ihe na-akpata insulin na-anabata insulin na kinase nke ala, na ?k? magnesium na-akpata nguzogide insulin.

?

Mitochondrial dysfunction: Mitochondria b? ?l? ?r? ike cell, na DNA ha na agb? iku ume na-ad? mfe imebi. Magnesium b? cation nke ab?? kachas? na mitochondria, nke na-etinye aka na njik? ATP na antioxidant, na ?k? magnesium na-eme ka mmebi mitochondrial d?kwuo nj?.

?

Senescence nke sel: mkp?r? nd? senescent kw?s?r? ikewa, zoo ihe nd? na-akpasu iwe, na-emebi microenvironment an? ah?. Magnesium nwere ike igbochi okirikiri cell igbochi protein p53 na p21 ma na-egbu oge senescence cell.

?

Mbelata cell cell: Mkp?r? nd? stem na-ah? maka mm?ghar? na nr?zi an? ah?, ?n? ?g?g? ha na ?r? ha na-agbada ka af?. Magnesium na-emet?ta sel hematopoietic stem cell, na ?k? magnesium nwere ike mee ka mbelata sel sel d?kwuo ngwa.

?

Mgbanwe na nkwur?ta okwu intercellular: cytokines, hormones, wdg na-emek?r?ta mgbanwe mgbaàmà intercellular. ?ka nká na-abawanye ihe nzuzo nke ihe nd? na-egbu egbu. Magnesium na-egbochi mbuf?t ma mee ka nkwur?ta okwu cell d?kwuo mma.

?

Autophagy na-ad?gh? mma: Autophagy b? ?z? d? mkpa maka mkp?r? nd? iji mebie protein na organelles mebiri emebi. Magnesium na-ejigide ?r? autophagy site n'?hazi ?r? nke mkp?r? nd? ihe nketa met?tara autophagy na kinase.

?

?r?a intestinal flora: flora eriri af? na-etinye aka na nri na-edozi ah? na nhazi nke usoro ah? ji al?so ?r?a ?g?, na ad?gh? mma microbial met?tara ?ka nká. Magnesium na-ach?kwa flora eriri af? ma na-eme ka ah?ike nd? ?b?a d?kwuo mma.

?

?r?a na-ad?gh? ala ala: ?ka nká na-esonyere ya na ?nya na-ad?gh? ala ala na-ad?gh? ala ala n'ime ah? dum, ya b?, "?ka nká". Enweghi ike Magnesium na-ebute oke ?gbalite ?z? mgbaàmà mkpali d? ka NF-κB ma na-eme ka nzaghachi mkpali d?kwuo nj?.

D? ka ?n? ?g?g? d? ukwuu nke ?r?a na-efe efe na nyocha nd? a na-ach?kwagh? ach?kwa, ?ba ?ba nke nri magnesium na-eri nri na ?kwado nkwadebe magnesium nwere ike ibelata af? mgbu na-ad?gh? ala ala, mgbochi insulin, ?r?a obi, wdg.

?

? b? ezie na magnesium d?t? mma, nd? nwere ?k? ak?r? kwes?r? ?kpachara anya, na nnukwu doses nke ?gw? ?n? nwere ike ?kpata af? ?s?sa. Nd? toro eto kwes?r? ibute ?z? inweta magnesium zuru oke site na nri ha, d? ka akw?kw? nri akw?kw? nd? akw?kw? nd?, mkp?r? osisi, mkp?r?, wdg. ? b?r? na ? d? mkpa, gbasoo nd?m?d? d?k?ta iji gbakwunye magnesium, ma na-enyocha ?bara magnesium mgbe niile.

?

Ihe akaebe nnwale zuru oke na data ?l? ?gw?:

?

Ihe akaebe nnwale nke magnesium na nkw?si ike genomic DNA b? mkp?r? nd? ihe nketa nke nd?, na nkw?si ike ya b? ihe ndabere maka ?r? ?r? nk?t? nke mkp?r? nd?. Nnyocha ah? ch?p?tara na e nwere ion magnesium n'etiti ihe d?ka 50% nke ?z? ab?? d? na DNA ab?? helix ?d?d?, nke na-ekere òkè n'ime ka nhazi ah? guzosie ike. N'ime ihe nlere anya d? ka Escherichia coli na yist, mpaghara magnesium d? ala na-ebute mm?ba d? ukwuu na ndezighar? DNA. Nnwale omenala fibroblast nke mmad? gosikwara na magnesium d? ala nwere ike ime ka mbelata telomere ngwa ngwa na nhazi usoro okwu nzaghachi mmebi DNA. Nnwale an?man? gosip?tara na usoro nchebe antioxidant mebiri na an? ah? imeju nke oke oke magnesium, na ?kwa nke 8-hydroxy-deoxyguanosine, akara nke DNA oxidative mebiri, m?bara. Nnyocha e mere na ?m? oke ch?p?tara na ??? mmiri nwere magnesium na-agbat? ogologo telomere ma belata mmebi DNA. Nsonaaz? nd? a na-egosi na magnesium d? mkpa maka ?n?gide na-enwe nkw?si ike genomic.

?

N'ime ?m?m? nd? mmad?, a na-ejik?ta ?kwa serum ma ? b? erythrocyte magnesium n'?z? na-ad?gh? mma na ihe ngosi d? iche iche nke nkw?s? nke genomic, d? ka micronucleus ugboro, ?kwa nke ngwaah?a mmebi DNA 8-hydroxy-deoxyguanosine, na ogologo telomere. Nnyocha nke ak?k? nke ihe f?r? nke nta ka ? b?r? 200 nd? okenye nwere ah?ike ch?p?tara na nd? nwere ?bara ?bara ?bara ?bara kachas? d? ala magnesium nwere ogologo lymphocyte telomere nke d? n'ak?k? ?bara nke b?, na nkezi, 11.5% d? mkp?mkp? kar?a nd? nwere ?kwa magnesium kachas? elu. ?m?m? otu nd? ?z? nke 1800 nd? agadi na nd? agadi 45-74 af? sochiri maka af? 5 ch?p?tara na oriri magnesium na-eri nri na-ejik?ta nke ?ma na ogo nke mmebi DNA na lymphocytes ?bara d? n'ak?k?, na mm?ba ? b?la na oriri magnesium nke 100mg / ?b?ch? belata ogo DNA mebiri site na 5.5% mgbe af? 5 gas?r?. Nke a na-egosi na mgbakwunye magnesium na ?m? mmad? nwekwara ike inye aka ?n?gide na-enwe nkw?si ike nke genomic.

?

Nke ab??, mmek?r?ta d? n'etiti magnesium na telomerase ?r? na cell ?ka nká Telomeres b? ihe owuwu p?r? iche na njedebe nke chromosomes, nke mejup?tara TTAGGG na-emeghachi na protein na-ejik?ta telomere, nke na-echebe chromosomes site na mmebi n'oge nkewa sel. Ma n'ime mkp?r? nd? mmad?, ogologo telomere na-ebelata site na 50 ruo 100 isi ?z? ab?? n'otu nkewa, na mgbe mkpirisi ah? ruru uru d? oke mkpa, cell na-abanye n'?n?d? nke ?d? nro. Telomerase b? ribonucleoprotease nke na-agbat? usoro telomere, mana a na-egosip?takar? ya nke ?ma ma ? b? na-egosighi ya na sel nd? okenye.

?

N'ime fibroblast embrayo embrayo (MEF), obere magnesium na-ebelata ?r? telomerase kar?a 50% ma gosip?ta njirimara senescence nke cellular, d? ka mm?ba β-galactosidase ?r? na nkwuputa nhazi nke nd? na-emechi okirikiri cell p16 na p21. Enwere ike gbanwee phenotypes ?ka nká mgbe a gw?chara ya na magnesium ma ? b? telomerase activators. A h?r? nsonaaz? nd? yiri ya na mkp?r? nd? endothelial mmad? na fibroblasts. ?m?m? usoro mkp?r? nd? ach?p?tala na magnesium nwere ike ?hazi ogologo telomere site na imet?ta okwu na nhazi nke ?f?d? protein nd? d? na telomere complex, d? ka TRF1 na TRF2. T?kwas? na nke ah?, magnesium nwekwara ike ime ka ?z? mgbaàmà d? ka AKT na ERK r?? ?r?, ma na-egbochi nd? na-eme ihe na-eme ka ?kp?kp? d? ka p53 na Rb, si otú ah? na-egbu oge ?ka nká cell.

?

?m?m? ?l? ?gw? na-akwadokwa njik? d? n'etiti magnesium na senescence cellular. N'ime ihe kar?r? 100 nd? agadi ah? siri ike, ?kwa magnesium serum nwere njik? chiri anya na mm?ba T lymphocyte na-ejik?ta ya na ?kwa p16 plasma. ?m?m? ihe ?z? g?nyere nd? agadi 250 n? n'ime obodo, ma ch?p?ta na ?kwa nke serum magnesium d? n'usoro nwere njik? chiri anya na mgbanwe nd? na-egosi ?ka nká physiological d? ka ?n? ?z? nt?, ike ijide, na ?s? ije ije, na-at? aro na ?n?d? magnesium nwere ike imet?ta usoro ?ka nká n'ime ah?. Nnyocha otu ìgwè nke ihe kar?r? mmad? 2,000 kar?r? af? 70 t?nyere ?kwa d? iche iche nke magnesium d? iche iche na ihe ize nd? nke af? 10 nke ?nw? wee ch?p?ta na ìgwè nd? nwere ?kwa magnesium d? ala nwere okpukpu 2.2 nke ?nw? kar?a otu nd? nwere ?kwa kachas? elu. ? b? ezie na ?m?m? ihe nlele nd? a enwegh? ike igosi kp?mkwem ihe kpatara ya na mmet?ta, ha na-akwado njik? siri ike n'etiti magnesium na ?ka nká site n'echiche nd? mmad?.

?

?r? nke magnesium na ?z? mgbaàmà insulin Insulin b? isi homon? na-ach?kwa nke glucose homeostasis ?bara mmad?. Mgbe insulin jik?tara ya na onye na-anabata ya, ? na-ebute phosphorylation nke onye na-anabata ya, ma na-ar? ?r? ?t?t? protein kinase d? ka PI3K na AKT, na n'ikpeaz? na-ahazi okwu mkp?r? nd? ihe nketa met?tara glucose metabolism. ?t?t? nnwale egosila na magnesium na-ekere òkè d? mkpa n'ihe f?r? nke nta ka ? b?r? nz??kw? ? b?la nke mgbaàmà insulin. 1. N'ime mkp?r? nd? beta nke agwaetiti, magnesium na-etolite mgbagwoju anya MgATP na ATP iji sonye na usoro insulin dum, nhazi na nzuzo. N'ime ah?r? sel beta nke òké na oke, ?kara magnesium d? ala belatara insulin na-akpali glucose kar?a 70%. 2. N'ime mkp?r? nd? insulin lekwas?r? anya, ?r? tyrosine kinase nke nd? na-anabata insulin na-adabere na ion magnesium, na ?k? magnesium na-eduga na insulin phosphorylation receptor phosphorylation na mgbama mgbanaka mgbada ala, na-akpata nguzogide insulin. N'ime 3T3-L1 adipocytes na sel skeletal skeletal L6, ?kara magnesium d? ala belatara nnabata glucose na-akpali insulin site na 40% ruo 60%. 3. Magnesium na-ekerekwa òkè na nhazi nke mmet?ta insulin site na igbochi protein phosphatase, na-ach?kwa okwu integrin, na-emet?ta ?r? nd? na-ebu GLUT4 na usoro nd? ?z?. ?f?d? nnwale an?man? egosila na mgbakwunye nri na-agafegh? oke nke magnesium na-eme ka nguzogide insulin na oke oke na ?d? oke nwere ?r?a shuga 2.

?

?m?m? ihe gbasara ?r?a na-akwadokwa mmek?r?ta chiri anya d? n'etiti magnesium na glucose metabolism. ?m?m? ah?ike nd? n??s? US, nke g?nyere ihe f?r? nke nta ka ? b?r? ?m? nwany? 70,000 gafere af? 45 sochiri ihe kar?r? af? 20, ch?p?tara na nd? n? na quintil kacha elu nke oriri magnesium na-eri nri nwere ihe ize nd? d? ala nke 27% nke ?malite ?d? ?r?a shuga 2 kar?a nd? n? na quintil kacha ala. Nyocha meta nke ?m?m? otu 25 nke met?tara ihe f?r? nke nta ka ? b?r? nde mmad? 1 gosiri na mm?ba 100mg kwa ?b?ch? na oriri magnesium na-eri nri na-ejik?ta na mbelata 8% ruo 13% n'ihe ize nd? nke ?d? ?r?a shuga 2. N'ime nd? nwere ?r?a shuga d? ad?, mbelata ogo magnesium serum na-enwekwa njik? chiri anya na ?ganihu ?r?a na nsogbu. Nnyocha e mere ihe kar?r? nd? ?r?a 300 nwere ?d? ?r?a shuga nke ab?? ch?p?tara na ?kwa magnesium d? ala nke ukwuu na nd? nwere ?r?a obi na-ar?a ?r?a obi kar?a nd? nwere ?r?a shuga naan?. N'ikpeaz?, ?n? ?g?g? d? ukwuu nke ?m?m? egosiwo na mgbakwunye magnesium nwere ike igbu oge ?ka nká site na imeziwanye nkw?s? insulin.

?

4. ?kw? Magnesium na mitochondrial dysfunction Mitochondria b? isi sa?t? nke cellular ume metabolism na reactive oxygen ?d? (ROS). N'oge usoro ?ka nká, ar?m?r? nke mitochondrial eletr?n transport chain na-ebelata na mmep?ta ROS na-abawanye, na-eme ka mtDNA mtDNA, membrane lipid peroxidation na mmebi nd? ?z?, na-eme usoro ?j?? ma na-eme ka ?ka nká cell d?kwuo elu. Nnyocha ach?p?tala na otu ?z? n'?z? at? nke magnesium n'ime ah? na-echekwa na mitochondria, nke d? mkpa maka ?n?gide na-ar? ?r? na mitochondrial. Na mouse imeju mitochondria, itoolu n'ime 13 subunits nke adenosine triphosphatase ch?r? magnesium d? ka onye na-emek? ihe. Na òké myocardial mitochondria, obere magnesium nwere ike ibelata ?r? nke enzymes isi na okirikiri triarboxylic acid, d? ka isocitrate dehydrogenase na α-ketoglutarate dehydrogenase. N'ime mitochondria imeju oke, ?k? magnesium nwere ike ibelata ?n?ego njik? ATP kar?a 60%, belata ?n? ?g?g? nch?kwa iku ume, ma na-abawanye mmep?ta ROS, na-ebute mm?ba na mtDNA mmebi na mm?ghar?. Mgbakwunye magnesium nwere ike weghachi ?r? mitochondrial nd? a. N'ime mkp?r? nd? skeletal nke mmad? na cardiomyocytes, magnesium d? ala nwere ike imebi ikike nke mitochondrial, mee ka oghere nke mitochondrial permeability transition pore (mPTP), kpalite nt?hap? nke cytochrome C, ma mes?a mee ka apoptosis p?ta. N'ime mkp?r? nd? endothelial vein nke mmad?, magnesium d? ala na-ebute ?n? ?g?g? d? ukwuu nke mitochondrial ROS site na-ar? ?r? protein kinase C, na-eduga na nkw?s? nke endothelial. Nnyocha nke ihe kar?r? 100 nd? ?r?a nwere ?r?a metabolic ch?p?tara na ?kwa magnesium serum nwere njik? chiri anya na ?r? iku ume mitochondrial yana emet?tagh? ?kwa mitochondrial ROS. Na nch?k?ta, ihe akaebe d? n'elu na-egosi na magnesium b? ihe d? mkpa n'?kwado homeostasis mitochondrial, na mitochondrial dysfunction b? otu n'ime isi usoro nke ?ka nká.

?

Nke ise, ?r? nch?kwa nke magnesium na mbuf?t na-ad?gh? ala ala na ?ka nká na-ad?gh? ala ala mbuf?t b? ak?k? ?z? d? mkpa nke ?ka nká. Nnyocha ach?p?tala na ?kwa nke ihe nd? na-egbuke egbuke d? ka IL-6 na TNF-α na nd? agadi na-am?bawanye nke ?ma, ebe ?kwa nke cytokines na-egbochi mkpali d? ka IL-10 na-ebelata, na steeti nd? a na-ad?gh? ala ala nke mere ?ka nká b? nke a maara d? ka "?k? ?k?". ?ka nká na-egbuke egbuke nwere ike ime ka ?kp?kp? an? ah? na-emebi emebi na ad?gh? ike, nke b? ihe ndabere nke ?t?t? ?r?a na-ad?gh? ala ala. Nnyocha nnwale egosila na ?k? magnesium nwere ike ime ka mmeghachi omume mkpasu iwe na ar?r? ?r? mgbochi. Na omenala macrophage òké, magnesium d? ala nwere ike ?kwalite ?r? NF-κB ma kwalite nt?hap? nke ihe d? iche iche na-akpasu iwe. N'ime mkp?r? nd? epithelial bronchial nke oke, ihe nzuzo nke IL-6 na IL-8 nwere ike ?bawanye site na 2 ruo 3 ugboro site na mkpali LPS n'okpuru ebe magnesium d? ala. N'ime mkp?r? nd? endothelial mmad?, magnesium d? ala nwere ike mee ka ?z? akara p38 MAPK r?? ?r?, na-eme ka nkwup?ta nke mkp?r? nd? adhesion intercellular na-ach?kwa, ma na-eme ka mmeghachi omume na-egbuke egbuke d?kwuo nj?. N'ime oke oke magnesium, ?kwa nke TNF-α, CRP na interleukin na-ekesa na an? ah? na-abawanye nke ukwuu, ak?k? ah? na-al?so ?r?a ?g? b? atrophy, ?n? ?g?g? na ?r? nke lymphocytes T na B na-ebelata, na immunosuppression na-akawanye nj?. Mgbakwunye Magnesium nwere ike ibelata nsogbu mkpasu iwe na mgbochi ?r?a nd? a nke ?ma. Nnyocha ?l? ?gw? ach?p?takwala na magnesium d? ala nwere njik? chiri anya na mbuf?t na-ad?gh? ala ala. Nnyocha nke ak?k? nke ihe kar?r? nd? okenye 5,000 na United States ch?p?tara na ntinye uche nke magnesium na-ejik?ta nke ?ma na CRP na ?n? ?g?g? ?bara ?cha, na ?kwa CRP na IL-6 na ?kwa kachas? elu nke magnesium d? 60% na 40% d? elu kar?a nd? n? na quartile kacha elu. Mmek?r?ta ah? siri ike kar?a na nd? buru ibu. Nnyocha ?z? nke nd? mmad? 3,200 kar?r? af? 65 ch?p?tara na ?kwa magnesium serum na-ejik?ta ya na ogologo telomere cell cell ?bara ?cha na nke na-ad?gh? mma na ?kwa CRP na D-dimer. Nnyocha meta nke ule 25 a na-ach?kwa na-enwegh? usoro yana ng?k?ta nlele nke ihe kar?r? mmad? 2,000 gosip?tara na mgbakwunye magnesium ?n? na-ebelata ?kwa CRP serum site na nkezi nke 22%, TNF-α site na 15%, na IL-6 site na 18%. Ya mere, mgbakwunye magnesium nwere ike igbu oge ?ka nká site na mmet?ta mgbochi mkpali.

?

Mmek?r?ta nch?kwa d? n'etiti magnesium na autophagy Autophagy b? usoro d? mkpa maka mmebi cell na mwep? nke protein na organelles mebiri emebi, ma d? oké mkpa maka ?n?gide na-enwe homeostasis nke gburugburu cellular. Nnyocha e mere egosiwo na ?r? autophagy na-eji nway?? nway?? na-ada mbà n'oge ?ka nká, na nt?p? na autophagy nwere ike ime ka nch?k?ta protein, mitochondrial dysfunction, wdg, ma mee ka ?ka nká cell d?kwuo elu. Magnesium, d? ka onye ozi nke ab??, na-etinye aka na nhazi mmalite na usoro nke autophagy. Na yist, ?k? magnesium na-egbochi nkwup?ta nke mkp?r? nd? ihe met?tara autophagy Atg1 na Atg13 site na ?gbalite ?z? akara TORC1. N'ime mkp?r? nd? mammalian, mpaghara magnesium d? ala nwere ike igbochi ?r? ULK1, Beclin1 na autophagy nd? ?z? na-ebute protein, ma gbochie mmep?ta nke autophagosomes. N'ime mkp?r? nd? ak?r? embrayo nke mmad?, onye na-ah? maka chelating magnesium ion EDTA nwere ike igbochi eruba autophagy. Nnwale in vitro egosila na mkpok?ta physiological nke ion magnesium nwere ike jik?ta ma r?? ?r? Atg4, enzyme proteolytic d? mkpa maka uto autophagosome. ?m?m? an?man? ach?p?tala na mgbakwunye nri na-agafegh? oke nke magnesium nwere ike ibelata ?r?a autophagy na neurons na cardiomyocytes, kwalite ?r? ?g?g? isi na ?r? systolic obi. ? b? ezie na enweghi ihe akaebe ?l? ?gw? kp?mkwem, ?f?d? nnyocha nyocha na-egosi njik? d? n'etiti magnesium na autophagy. A na-ejik?ta ?kwa Magnesium nke ?ma na nkwup?ta autophagy markers Atg5 na Beclin1 na ?b?r? ?b?r? na mkp?r? nd? mononuclear ?bara nke nd? ?r?a nwere ?r?a Alzheimer. N'ime nd? ?r?a nwere ?r?a shuga 2d? nke ab??, ntinye uche nke magnesium serum nwere njik? chiri anya na ?kwa ngosip?ta nke mkp?r? nd? ihe nketa autophagy LC3 na p62. N'ikpeaz?, magnesium nwere ike ?r? ?r? d? mkpa n'iguzogide ?ka nká site na ?hazi autophagy. Mana ? d? mkpa ka a m?? usoro ya kp?mkwem.

?

7. Mmek?r?ta d? n'etiti Magnesium na intestinal flora Intestinal flora b? "ihe" d? mkpa n'ime ah? mmad?, nke na-ar? ?r? na-enwegh? ike dochie ya na metabolism nutritional, usoro mgbochi, neuroendocrine na ak?k? nd? ?z?. Nnyocha e mere n'oge na-ad?begh? anya ach?p?tala na mgbanwe na nhazi na ?r? nke microbiota gut nwere njik? chiri anya na ?ka nká. D?ka ?m?maat?, ?n? ?g?g? nke firmicutes na Bacteroides d? na eriri af? nd? agadi na-ebelata nke ukwuu, ebe oke nke ?r?a nje d? ka enterococcus na Staphylococcus m?bara. Enwegh? ahagh? nhata nke ah?h?a nd? nwere ike imebi ihe mgbochi eriri af?, kwalite nt?hap? nke ihe nd? na-akpasu iwe, na ime ka ?z?za na-ad?gh? ala ala na ah? dum ka nj?.

?

D? ka ihe d? mkpa na-edozi ah? na eriri af?, magnesium nwere ike imet?ta nhazi nke osisi site na usoro d? iche iche. N'ime ?m? oke na-enwegh? nje, mmiri ????? bara ?ba na magnesium nwere ike ?bawanye ?n? ?g?g? nje bacteria bara uru d? ka bifidobacterium na Bacteroides, ma belata uru pH intestinal. N'?d? òké nke colitis, mgbakwunye magnesium na-ebelata ?gba aghara osisi intestinal ma gbochie NF-κB n'ime ?z? mgbaàmà mkpali. N'ime nnwale mmad? nwere ah?ike, ?n??g? bifidobacteria na ns? m?bara ka izu asat? nke mgbakwunye magnesium gas?r?, ?kwa lipopolysaccharide, D-lactic acid na metabolites nje nd? ?z? belatara. ?f?d? ?m?m? nyocha ach?p?tala na ?k? magnesium nwere ike ?kpaghas? njik? nke eriri af?, m?baa permeability, ma mep?ta ?n?d? maka nt?ghar? nke endotoxins enterogenic.

?

Magnesium nwekwara ike imet?ta usoro ?ka nká nke onye ?b?a site na ?hazi metabolism nke nje bacteria. D?ka ?m?maat?, magnesium na-akpali mmep?ta nke acid fatty d? mkp?mkp? d? ka Bifidobacterium, nke na-eme ka G-protein jik?tara ya na GPR43, nke na-egbochi mbuf?t met?tara oke ibu na nkw?s? insulin. Na mgbakwunye, magnesium nwekwara ike imet?ta bile acid na tryptophan metabolism, na nsogbu nke ?z? ab?? a nwere njik? chiri anya na ?ka nká na ?r?a neurodegenerative. N'ikpeaz?, a na-at? anya na magnesium ga-ab? at?mat? ?h?r? maka igbu oge ?ka nká site n'?hazighar? osisi intestinal na ?hazi axis bacteria-gut-brain axis, mana ? d? mkpa ka a ch?p?ta mmet?ta ya ogologo oge site na nch?p?ta nd? na-at? anya ya.

?

Na nch?k?ta, ?n? ?g?g? d? ukwuu nke nnwale na ?r?a na-efe efe na-egosi na magnesium b? ihe oriri d? mkpa iji guzogide ?ka nká ma kwalite ah?ike na ogologo nd?. ? na-etinye aka na nhazi nke ?ka nká site na usoro nd? a:

?

? b? ezie na mmet?ta nke mgbakwunye magnesium na nd? mmad? ugbu a ad?gh? agw? agw?, ihe àmà na-ap?tagh? ìhè na-egosi na magnesium nwere ike inye aka igbu oge ?t?t? phenotypes ?ka nká ma melite at?manya ah?ike. N'?d?nihu, a na-ach? ?m?m? ihe nd? a na-at? anya ya na nyocha nd? a na-ach?kwagh? ach?kwa iji dokwuo anya mmet?ta mgbochi ?ka nká nke magnesium na mmek?r?ta ya na dose-mmet?ta ya, iji nye ihe akaebe na-egosi maka ?mep?ta at?mat? mgbakwunye magnesium. Na mgbakwunye, ?n?d? nri magnesium na ?ch?ch? nke nd? mmad? d? iche iche ab?gh? otu, ya mere nhazi nke mmemme mgbakwunye magnesium n'otu n'otu b?kwa nsogbu d? ngwa a ga-edozi. A kwenyere na site na mmepe nke ?gw? ?ka nká na ihe oriri na-edozi ah?, any? ga-emecha kpughee ihe omimi nile nke ihe omimi a nke magnesium, ma jiri ya l?so ?ka nká ?g? ma gh?ta nr? nke ogologo nd? ah?ike.

?