Nke mb?, ah?ike agadi na mgbochi ?ka nká

D? ka isi metabolite nke leucine, HMB-Ca egosila uru p?r? iche na mgbochi na ?gw?gw? nke senile muscle decay syndrome (sarcopenia). Data ?l? ?gw? na-egosi na nd? agadi kar?r? af? 65 na-agbakwunye gram 3 nke HMB-Ca kwa ?b?ch?, yana ?z?z? nkw?si ike na-agafegh? oke, mgbe izu iri na ab?? gas?r?, nkezi ah? ike nke ak?k? ah? m?bara site na 1.2kg, ike njide m?bara site na 14%, na ?kwa nkwalite ?s? ?s? ruru 23%?34. Usoro ?r? ya g?nyere:

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?kwalite ?z? mTOR: mm?ba protein njik? protein muscle na-ar? ?r? site na 38%

Egbochiri sistemu protease ubiquitin: belatara ngosip?ta nke akara nr?ba akwara (d? ka MuRF1) site na 41%

Na-edozi nguzozi mbuf?t: na-ebelata ?kwa nke pro-inflammatory IL-6 site na 29% ma na-eme ka ?nya na-ad?gh? ala ala.

N'ihe gbasara mgbochi ?ka nká, usoro ntinye aka nke HMB-Ca jik?tara ya na vitamin D3 na-ebelata ?n? ?g?g? nke ?nw? telomere site na 17% ma belata ihe nr?bama secretory phenotype (SASP) met?tara cell site na 34% ?. National Longevity Medical Research Center d? na Japan na-eme nnwale ?l? ?gw? nke ab?? nke HMB-Ca iji belata ?ganihu nke ?r?a Alzheimer, na data mbido na-egosi mm?ba 19% na akara ?r? ?g?g? isi.

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2.Construction nke ?l? ?gw? na-edozi usoro nkwado

HMB-Ca na-ap?ta d? ka isi ihe na-edozi ah? n'?gw? ?r?a nd? d? oke egwu na nke na-ad?gh? ala ala:

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Nlek?ta cachexia cancer: Mgbakwunye gram 3 nke HMB-Ca mgbe ar?chara ?r? na omega-3 fatty acids na nd? ?r?a nwere ?r?a cancer colorectal nwere ike belata ?nw? an? ah? site na 62% ma mee ka nnabata chemotherapy d? elu site na 38%

Nkwado nr?zi ?k?: 30% nke nd? ?r?a na-ere ?k? na-eji nri nri na-edozi ah? nwere HMB-Ca, oge ?gw?gw? ?nya na-ebelata site na ?b?ch? 5-7, na protein catabolic ?n?ego belatara 41%

Ngwa mmeghari iku ume: Ejik?tara ?n? HMB-Ca na branchchain amino acid na nd? ?r?a COPD, ?nwa isii ka e mes?r?, njem nkeji 6 m?bara site na mita 82, ike nke akwara iku ume m?bara site na 21% ?

US FDA akwadola HMB-Ca d? ka "?gw? mgbei" maka ?gw?gw? nke Duchenne muscular dystrophy, na nkeji III data ?l? ?gw? gosiri na elu ?r? akara aka elu site na 28% na usoro myocardial fibrosis na-egbu oge site na 19% ?

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3. ?ganihu na njikwa ?r?a metabolic

Usoro ?h?r? nke HMB-Ca na nhazi nke metabolism glycolipid ekpughere:

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Mmet?ta insulin: N'ime nd? ?r?a nwere ?d? ?r?a shuga 2 nke agbakwunyere na HMB-Ca maka izu iri na ab??, HOMA-IR index belatara site na 23% yana oriri glucose na akwara skeletal m?bara site na 37%

Mgbanwe nke metabolism ab?ba: Site na ?gbalite ?z? AMPK, ?d?naya triglyceride imeju belatara site na 29% yana ?kwa adiponectin m?bara site na 18%.

Gut microbiota regulation: mmep?ta acid fatty acid d? mkp?mkp? m?bara site na 42% yana akara ?r? mgbochi eriri af? na-abawanye site na 31% site na mgbanwe nke firmicutes/Bacteroides ratio ?

Na ?gw?gw? ?r?a imeju ab?ba na-ad?gh? egbu egbu, usoro ntinye aka nke HMB-Ca jik?tara ya na silymarin belatara akara fibrosis imeju site na 1.2 ma mee ka ?n??g? ALT d? elu ruo 68%?57. Nnyocha ?m?m? RCT na ?n? ?g?g? nd? nwere ?r?a metabolic gosip?tara mbelata 19% na akara ihe ize nd? nke obi (ASCVD) mgbe izu 24 nke ntinye aka gas?r?.

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4.Food ?h?r? maka ?gw?gw? p?r? iche

Usoro ?gw?gw? p?r? iche dabere na HMB-Ca na-edeghar? mpaghara nri ?l? ?gw?:

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Ndozighar? tupu ?wa ah? : N'ime nd? ?r?a nwere ngbanwe nkwonkwo, ?gbakwunye 6 grams nke HMB-Ca / ?b?ch? 3 ?b?ch? tupu ?wa ah? nwere ike imeziwanye ?s? nke ike mgbake ah? site na ugboro 2.3 ma belata ogologo oge ?n? n'?l? ?gw? site na ?b?ch? 2.5 ?

Nchedo radieshon megide ?r?a kansa: Mgbakwunye oriri na-edozi ah? nke nwere HMB-Ca n'isi na olu radiotherapy nd? ?r?a belatara ?n? ?g?g? nke mucositis site na 41% yana mm?ba uto uto site na 57%

Nkwado oriri na-edozi ah? nke nwa am?r? ?h?r?: Mgbakwunye HMB-Ca (50mg/kg/d) n'ime usoro nwa ?h?r? m?bara ibu ah? site na 24% yana akara neurodevelopmental site na 19%

K?m?sh?na ah?ike mba nke China etinyela HMB-Ca n'ime katal?g? nke Raw Materials of Formula Food for Special Medical Use, ma kwado ngwa ya n'?d? ngwaah?a 6, g?nyere etuto nri mkpok?ta nri na ?r?a shuga kp?mkwem usoro nri nri 8. Tekn?z? microsphere na-ewep?ta HMB-Ca nke emep?tara na Japan nwere ike ?bawanye ?n?ego mm?nye eriri af? ruo 91% wee belata ngbanwe nke mkpok?ta ?gw? ?bara na ± 7%?

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5.Extension nke egwuregwu mmeghari ?gw?

N'ofe ubi nri egwuregwu ?d?nala, itinye HMB-Ca na ?gw? ndozi na-aga n'ihu na-agbasa:

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Ngw?ta mmer? ah? nke akwara: N'ime nd? ?r?a nwere mmer? ah?, njik?ta nke HMB-Ca na mkpali eletrik na-ar? ?r? na-abawanye mpaghara ak?k? nke ak?k? ah? nke f?d?r? site na 17% na akara ADL site na 23% mgbe ?nwa 6 gas?r?.

mgbake ?wa ah? nke orthopedic: mgbe nwughari ligament nke ihu, gbakwunye HMB-Ca, ogo quadriceps atrophy belatara site na 58%, nloghachi mmega ah? 3-4 izu tupu mgbe ah? ?

Ngwa ?gw? Aerospace: Nd? na-enyocha mbara igwe na International Space Station gbakwunyere na gram 3 nke HMB-Ca kwa ?b?ch? na-ebelata mfu an? ah? na microgravity site na 72% yana ?n?ego njup?ta ?kp?kp? site na 39%?

N'ihe gbasara nchebe mmer? egwuregwu, usoro nhazi nke HMB-Ca belatara ?n? ?g?g? creatine kinase kacha elu site na 44% na ogologo oge mgbu ah? na-egbu oge site na 51% mgbe mmega ah? centrifugal gas?r?. òtù Na-ah? Maka Egwuregwu Egwuregwu nke Britain na-at? aro na ?malite mmemme mgbakwunye HMB-Ca 2 izu tupu ihe omume d? elu nwere ike ibelata ihe ize nd? nke nnukwu mmer? ah? site na 37% ?

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6.Future frontier: Biotechnology integration na ?h?r?

Ngwa interdisciplinary nke HMB-Ca na-ewep?ta usoro tekn?z? ?h?r?:

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Usoro nnyefe Nano: Nkwadebe ezubere iche nke HMB-Ca nke etinyere na liposome na-abawanye mkpok?ta an? ah? site na ugboro 3.7 na oge d? irè na-agbat? ruo awa 72.

Nkwadebe bayoloji s?ntetik: Ego HMB-Ca belatara site na 62%, ?d? ?cha nke HMB-CA ruru 99.9% ?k?l?t? ?kwa ?gw?.

Ntinye aka na nri dijital?: ngwa?r? wearable jik?tara HMB-Ca smart supported-release patch, na-agbanwe usoro nt?hap? d? ka EMG n'ezie.

?ganihu na-edezi mkp?r? nd? na-enyere aka ?hazi usoro ?z? metabolic HMB, yana mgbasawanye nke CRISPR-Cas9 nke HMB synthase butere mm?ba eke 29% na oke akwara na ?d? òké. Nkwadebe prodrug HMB-Ca nke mb? n'?wa abanyela n'?kwa ngwa ?l? ?gw?, yana bioavailability ya d? elu ugboro 2.8 kar?a nke ?d? usoro ?gw?gw? ?d?nala.

Nchekwa na ngwa nk?wa

Agbanyegh? na HMB-Ca na-egosi at?manya ngwa sara mbara, ? ka d? mkpa iburu n'obi:

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Usoro nch?kwa dose: a na-at? aro iji ogologo oge mee ihe ka ? ghara ?gafe 5 g / ?b?ch?, oke nwere ike ime ka ah? erugh? ala eriri af?.

Nkwalite oge: A na-at? aro ka ? were ya na nri ugboro 2-3, yana itinye uche ?bara kacha elu dabara na oge mmega ah?.

contraindications: Iji ?gw? antioxidants d? elu mee ihe nwere ike imebi ?z? mTOR.

Usoro nke International Society of Sports Nutrition (ISSN) t?r? aro na-egosi na mgbakwunye HMB-Ca maka izu 2-3 na-enye nsonaaz? kacha mma, yana enwere ike ?hazighar? usoro mmezi ka ? b?r? 1-2 g / ?b?ch?. Site na mkpok?ta ihe akaebe ngwa ?l? ?gw?, HMB-Ca na-etolite site na mgbakwunye nri na-ar? ?r? nke ?t?t? ?z?z?, yana oke uru ya ka na-agbasa.