N'ime af? nd? na-ad?begh? anya, ibu ?n? agh?wo ?kacha mmas? ?h?r? nke nd? ?kà mm?ta sayens?, egosiwo na ibu ?n? na-ebelata ibu ma na-agbat? nd? ?m? an?man?, n'eziokwu, ?n? ?g?g? na-ar?wanye elu nke ?m?m? na-egosi na ibu ?n? nwere ?t?t? uru ah?ike, na-eme ka ah? ike metabolic d?kwuo mma, igbochi ma ? b? na-egbu oge ?r?a nd? na-ab?a na ?ka nká, na ?b?na na-ebelata uto nke etuto ah?.
E gosiputara ibu ?n? nwa oge, d? ka mmachi caloric, ?gbat? ogologo nd? yana ogologo nd? an? ah? d? mma d? ka yist, nematodes, ijiji mkp?r?, na oke. N'ime ?m? mmad?, ibu ?n? na-ad?te aka na ogologo oge, yana nkw?s? caloric na-aga n'ihu, nwere mmet?ta d? mma na ?t?t? ihe met?tara ah?ike nke nwere ike inwe usoro nhazi nk?t?, na e nwere ihe àmà siri ike na autophagy na-edozi mmet?ta nd? a.

T?kwas? na nke ah?, spermidine (SPD) ejik?tawo n'otu aka ah? na nkwalite autophagy, mgbochi ?ka nká, na mbelata ?r?a obi na ?r?a neurodegenerative n'ofe ?d?.

N'August 8, 2024, nd? nyocha sitere na Mahadum Graz d? na Austria, Sorbonne na Paris na Mahadum Crete d? na Gris bip?tara akw?kw? akp?r? "Spermidine d? mkpa maka ibu ?n? na-ebu ?n? na autophagy" na akw?kw? ak?k? Nature Cell Biology na ogologo nd? "akw?kw? nyocha.

Nnyocha e mere egosiwo na spermidine d? mkpa maka ngwa ngwa na-agba ?s? ngwa ngwa na ogologo nd?, nakwa na ?ganihu nke oge nd? na ah?ike site na-ebu ?n? na ?t?t? ?d? na-adabere na spermidine-based eIF5A-hypusination modification na ntinye nke autophagy na-esote.

N'ime an? mammals, mbelata nd? met?tara af? na autophagy flux na-akwalite mkpok?ta protein aggregates na organelles na-ad?gh? ar? ?r?, yana ?d?da nke mkpochap? nje na ?ba ?ba.

Mgbochi nke autophagy na ?kwa mkp?r? nd? ihe nketa mere ka usoro ?ka nká na ?m? oke d?kwuo elu. ?nw? nke mm?ghar? na-ar? ?r? na mkp?r? nd? ihe nketa na-ach?kwa ma ? b? na-eme autophagy b? ihe jik?r? ya na ?r?a obi, ?r?a na-efe efe, ?r?a neurodegenerative, na ?r?a metabolic, musculoskeletal, anya, na ng?g?, ?t?t? n'ime ha yiri ?ka nká. N'?z? d? iche, mkpali autophagy na ?kwa mkp?r? nd? ihe nketa na-akwalite ogologo nd? na ah?ike ogologo nd? na an?man? ihe at?, g?nyere ijiji na ?m? oke.

Na mgbakwunye na ihe oriri na-edozi ah?, iji polyamine spermidine eke eme ihe n'?d? an?man? nd? d? ka yist, nematodes, ijiji mkp?r? osisi, na ?m? oke b? at?mat? ?z? iji gbasaa ogologo nd? n'?z? dabere na autophagy. T?kwas? na nke ah?, spermidine nwere ike iweghachite flux autophagy na-ekesa lymphocytes na nd? agadi, b? nke kwek?r? na nleba anya na ?bara spermidine nri na-eri nri na-ejik?ta ?n? na ?n? ?g?g? nd? mmad? na-anw? anw?.

Spermidine b? ?d? polyamine sitere n'okike nke d? n'?t?t? ebe n'ime ihe nd? d? nd?. N'ime af? nd? na-ad?begh? anya, nch?p?ta na-ar?wanye elu egosiwo na spermidine nwere mmet?ta anwansi ma d? ike na-egbochi ?ka nká.

Ya mere, ibu ?n?, mmachi caloric, na spermidine na-agbat? nd? nke an?man? ihe at? ma mee ka ihe nchebe nke phylogenetic na-echekwa, autophagy dabere na ?ka nká. N'ime ?m?m? ihe ?h?r? a, nd? otu nyocha gara n'ihu nyochara ma mmet?ta nchebe geriatric nke ibu ?n? na-ad?te aka na-emet?ta ma ? b? dabere na spermidine.

Nnyocha ah? ch?p?tara na ?kwa spermidine m?bara na yist, ijiji mkp?r? osisi, ?m? oke na ?m? mmad? n'okpuru oke ?n? ma ? b? usoro mgbochi caloric d? iche iche. Mkp?r? nd? ihe nketa ma ? b? ?gw? na-egbochi njik? spermidine endogenous na-ebelata autophagy ngwa ngwa na yist, nematodes, na sel mmad?.

T?kwas? na nke ah?, itinye aka na ?z? polyamine d? n'ime ah? nwere ike iwep? mmet?ta ogologo oge nke ibu ?n? na ogologo nd? na nd? ah?ike, yana mmet?ta nchebe nke ibu ?n? na obi na mmet?ta mgbochi ?r?a ogbu na nkwonkwo.

Mechanical, spermidine na-edozi mmet?ta nd? a site n'?kwalite autophagy na hypusination nke mmalite mmalite nt?ghar? eukaryotic eIF5A. The polyamine-Hypusination axis b? phylogenetically chekwara usoro nhazi usoro metabolic na nkwalite autophagy na-agba ?s? ?s? ?s? yana nd?t? nd?.

N'ozuzu, ?m?m? ihe na-egosi na mmelite nke ibu ?n? na ogologo nd? na ogologo nd? ah?ike n'?t?t? ?d? na-adabere na spermidine na-adabere na eIF5A-hypusination mgbanwe na ntinye nke autophagy na-esote.