Lycopene (LYC), carotenoid, b? agba na-agbaze ab?ba, nke a na-ah?kar? na tomato, any?, mkp?r? osisi grepu na mkp?r? osisi nd? ?z?, b? isi pigmenti na tomato chara acha. Lycopene nwere uru ah?ike d? iche iche, g?nyere ?ch?p? radicals efu, na-ebelata mbuf?t, na-ach?kwa glucose na metabolism lipid, yana mmet?ta neuroprotective.

N'oge na-ad?begh? anya, nd? nch?p?ta si Shanxi Medical University bip?tara akw?kw? n'akw?kw? ak?k? Redox Biology nke isiokwu ya b? "Lycopene na-ebelata ihe mgbagwoju anya nke af? site na-ar? ?r? imeju-?b?r?. Akw?kw? nyocha nke fibroblast growth factor-21 signing ".

Nnyocha e mere egosiwo na mgbakwunye na lycopene maka ?nwa 3 nwere ike igbu oge ?b?r? ?b?r? na ?m? oke ma belata mmebi nke uche met?tara af?, na lycopene na-eme ka mmebi nke neuronal, mitochondrial dysfunction, synaptic mmebi, na-akwalite synaptic vesicle fusion na ?ka nká ?m? oke.

Na mgbakwunye, lycopene na-ar? ?r? imeju-?b?r? axis FGF21 na-egosi na ?m? oke ?ka nká, si otú ah? na-akwalite nt?hap? nke neurotransmitters site n'?bawanye ?kwa ATP mitochondrial na ?kwalite synaptic vesicular fusion. Nke a na-egosi na FGF21 nwere ike ?b? ebumnuche ?gw?gw? na usoro ntinye aka n'ihe oriri na-edozi ah? iji gbuo oge ?ka nká na imeziwanye nsogbu ?g?g? isi met?tara af?.

Na ?ka nká, ?b?r? ?ka nká, nkw?s? nke mitochondrial b? otu n'ime ihe nd? kachas? mkpa, nd? nch?p?ta ch?p?tara na mgbakwunye lycopene nwere ike imeziwanye mmebi nke mitochondrial morphological, ma gbanwee ?kwa nke mitochondrial electron transport chain complex nke mere site na ?ka nká, na-akwalite mmep?ta nke ATP, na-egosi na lycopene nwere mmet?ta nchebe na ?r? mitochondrial.

N'ikpeaz?, nd? nch?p?ta ah? mekwara nnwale na vitro wee ch?p?ta na lycopene kwalitere ikike nke mkp?r? nd? imeju iji kwado neurons, g?nyere imezi ?ka nká cell, ?kwalite ?r? mitochondrial, na ?bawanye ogologo axon neuron.

N'?ch?k?ta ?n?, nsonaaz? ya na-at? aro na mgbakwunye lycopene nwere ike igbu oge ?b?r? ?ka nká ma gbochie mmer? ah? met?tara af? na ?m? oke, n'otu ak?k? n'ihi na lycopene na-ar? ?r? hepato-brain axis FGF21 na-egosi, na-at? aro na FGF21 nwere ike ?b? ihe nwere ike ?gw? ?r?a na ntinye aka na-edozi ah? iji mee ka ?r?a na-ad?gh? mma na-emet?ta ?b?r? na-ad?gh? mma.