Citicolineejirila ya mee ihe n'?t?t? ebe na omume ?l? ?gw?, tumadi maka ?gw?gw? nke usoro akwara ozi nke mmer? ah? craniocerebral ma ? b? ihe mberede cerebrovascular kpatara, wee ch?p?ta ojiji ?h?r? na omume ?l? ?gw?. ?gw?gw? ya na ?bara ?gb?gba ?b?r?, ?r?a Parkinson, glaucoma, ?r?a mam?r? peripheral neuropathy na tinnitus na ?r?a nd? ?z? ad?tala nlebara anya na-abawanye ?ba. Ya mere, g?n? b? citicoline, kedu mmet?ta pharmacological, ihe ngosi ya (?gw?gw? kp?mkwem nke ?r?a), ?d? irè na nchekwa?

Citicoline b? otu nucleotide mejup?tara ribose, cytosine, pyrophosphate na choline. ? b? nucleotide endogenous nke ah? mmad?. ? na-etinye aka na ?t?t? ?z? metabolic d? mkpa na ah?. ? b? ihe mmalite sitere n'okike nke njik? phospholipid nke usoro akp?kp? an? neuron na ihe mmalite nke biosynthesis nke neurotransmitter acetylcholine.

Citicoline b? onye na-ah? maka neuroprotective nke nwere ike ichebe akwara nd? na-ad?gh? ike, si otú ah? belata ma ? b? gbochie ?ganihu ?r?a. Ugbu a, neuroprotective agents nd? a na-ejikar? eme ihe na ?l? ?gw? g?nyere calcium channel blockers, glutamate antagonists, free radical scavengers, na cell membrane stabilizers, n'ime nke citicoline b? nke cell membrane stabilizers.

Citicolinenwere mmet?ta ?gw? ?gw? d? iche iche, na usoro nd? a na-eme ka ? nwee ikike d? ukwuu na neuroprotection na nr?zi akwara. ? nwere mmet?ta neuroprotection nke igbochi ihe omume nke mmer? ah? na mmet?ta nr?zi akwara mgbe ihe kpatara mmer? ah?, nke na-eme ka windo oge ?gw?gw? nke citicoline gbasaa.

Dabere na ak?r?ngwa ?gw? ya, a na-eji citicoline eme ihe n'?t?t? ebe n'?gw? ?r?a strok, nkwar? ?g?g? isi, mmer? ah? ?b?r? traumatic, ?r?a Parkinson, glaucoma, neuropathy peripheral neuropathy na-ar?a ?r?a shuga, tinnitus na ?r?a nd? ?z?, na ar?m?r? ya na nchekwa egosip?tara n'?t?t? ?m?m? ?l? ?gw?, yana ihe akaebe ah?ike zuru oke. ?r?a strok: ?r?a strok b? ?d? mgbochi vask?la ?b?r? ma ? b? mgbawa, na-ebute mmebi ?b?r? nke otu ?d? ?r?a, g?nyere ischemic na hemorrhagic strok, nke ?r?a strok ischemic b? isi ?d? ?r?a strok, na-aza 75% ruo 90% nke ?r?a strok niile. Ihe ize nd? nd? nke ?r?a strok na nd? bi na any? b? 35%-40.9%, ?kwa mb? n'?wa, ? b?gh? naan? nke ah?, ?r?a strok b?kwa ihe mb? na-akpata ?nw? na nkwar? na nd? bi any?.

Ihe akaebe nyocha ?l? ?gw?:

1. Na 2002, American Journal Stroke bip?tara meta-analysis nke ?l? ?gw? ule na nd? ?r?a nwere nnukwu ischemic ?r?a strok, nke gosiri na onu citicoline m?bara ohere nke ?r?a strok agbake mgbe ?nwa 3 [1].

2. Na 2009, a na-eduzi nyocha nyocha ?gw? na South Korea maka nd? ?r?a 4191 nwere nnukwu ?r?a strok ischemic, na nsonaaz? ya gosip?tara na citicoline kwalitere akara NIHSS na akara BI nke nd? ?r?a nwere uru na mmalite na ?gw?gw? mbubreyo, na uru ngwa ngwa ogologo oge d? ukwuu, na mmet?ta ?gw?gw? na-ejik?ta ya na dose. ?ganihu ah? d? ?r?ba ama na otu nnukwu doses (≧2000mg / ?b?ch?), na ngwa ogologo oge ad?gh? mma ma na-anabata ya [2].

3. Nsonaaz? nke multicenter, randomized, okpukpu ab?? kpuru ìsì, placebo na-ach?kwa ?bara ?gb?gba na ?b?r? ?b?r? na-egosi na citicoline b? ?gw? d? mma maka ?gw?gw? ?bara ?gb?gba ?b?r? nwere mmet?ta ?gw?gw? d? mma [3].

4. Ihe omumu nke mepere emepe, nke a na-ahaziri ahazi, nke yiri nke a t?lere mmet?ta citicoline na mmer? ah? nke ?r?a strok post-stroke, na nsonaaz? gosiri na iji citicoline ogologo oge na-eme ka ? d?kwuo mma nh?sianya ?b?r? post-stroke [4].