?ka nká b? usoro mgbagwoju anya, ?t?t? ?kwa, usoro nway?? nway?? na-eme na nd?. Ka oge na-aga, ak?k? ah? na m?z?l? nke ah? mmad? ga-eji nway?? nway?? na-aka nká, ?r?a ?f?d? ga-enwekwa n'oge uto nke af?, g?nyere ?r?a kansa, ?r?a shuga, ?r?a obi na ihe nd? ?z?.

Nnyocha nd? ?z? egosila na phytochemicals, g?nyere polyphenols, flavonoids, terpenoids, wdg, nwere ike ?gbat? nd? ah?ike site na mgbochi oxidation, ?gbalite autophagy mitochondrial na usoro nd? ?z?, ma nwee ihe mgbochi ?ka nká.

Na mb?, nd? na-eme nch?p?ta ch?p?tara na sage wep? nwere ike igbu oge ?ka nká na vitro nnwale, na na òké na mmad? in vitro ?d?, sage wep? budata belata ?n? ?g?g? nke nti af?-met?tara beta-galactose sidase cell, na-egosi mgbochi ?ka nká Njirimara.

N'oge na-ad?begh? anya, nd? na-eme nch?p?ta na Mahadum Padova d? na ?tali bip?tara akw?kw? na akw?kw? ak?k? Nature Aging isiokwu ya b? "?t?le senescence na-akpali site na af? ma ? b? chemotherapy na polyphenol-?garanya. eke wep? mma ogologo nd? na ah?ike na ?m? oke."

Nnyocha e mere egosiwo na ??? ihe ????? sage kwa ?b?ch? nwere ike ?gbat? nd? nd? na ah?ike nke ?m? oke, na-egbochi mbuf?t nke af?, fibrosis na akara ?ka nká na ?d? an? ah? d? iche iche, ma melite phenotypes ?ka nká.

N'ime ?m?m? ihe a, nd? nch?p?ta nyochara ikike ?ka nká nke sage wep? (HK) na vivo site na ?d? òké, site n'?gbakwunye obere doses nke HK na mmiri ????? kwa ?b?ch?, na nyochaa nch?k?ta mkp?r? nd? senescent na ?d? òké, yana ?t?t? ihe met?tara af?, g?nyere ogologo nd?, ah?ike an? ah?, fibrosis, ?kp?kp? ?kp?kp?, na mbuf?t.

Nd? nch?p?ta ah? nyere ?m? oke d? ?nwa 20 mmiri ????? nwere HK ruo mgbe ha nw?r?.

Nsonaaz? gosiri na nkezi nd? ?m? oke na otu ?gw?gw? HK b? ?nwa 32.25, ebe nkezi nd? ?m? oke na otu njikwa b? naan? ?nwa 28. ?gw?gw? HK gbat?r? ogologo nd? site na ?nwa 4.25, ma ogologo nd? nke ?m? oke nwoke na nwany? gbat?kwara nke ukwuu.

Nyocha ak?k? ihe mere eme nke akp?kp? an?, imeju, ak?r?, na ng?g? nke ?m? oke ch?p?tara na ?gw?gw? HK emegh? ka mgbanwe d? na mkp?r? nd? hematopoietic ma ? b? ns? an? ah?, na-egosi na ?gw?gw? HK ad?gh? mma.

Na mgbakwunye, ?gw?gw? HK kwalitere phenotypes ?ka nká na ?m? oke ma e jiri ya t?nyere njikwa, g?nyere ak?k? nke hunchback, mmepe tumor, na ?n?d? aj? an?.

Nsonaaz? nd? a na-egosi na ?gw?gw? HK nwere ike ?gbat? ogologo nd? ah?ike na ogologo nd? ?m? oke, ? nwegh?kwa nsi na-ah?.

Nnyocha ?z? ch?p?tara na ?gw?gw? HK kwalitere phenotypes ?ka nká n'?d? an? ah? d? iche iche, g?nyere mma ntutu isi, ?kp?kp?, ah? ike, na ?r? ak?r?.

Nyocha usoro na-egosi na ?gw?gw? HK na-ach?kwa nke ?ma n'usoro mkp?r? nd? ?ka nká set?p?r? SAUL_SEN_MAYO, ebe usoro ?ka nká na-ejik?ta ya na nr?anr?a nke mbuf?t, ?gbalite ihe mgbochi, na ?z? nd? met?tara af?, na-at? aro na ?gw?gw? HK gbanwere njirimara transcriptome met?tara mbuf?t na ?ka nká. T?kwas? na nke ah?, nyocha nke uru ah?, akp?kp? ah?, ak?r?, na ng?g? ch?p?tara na ?gw?gw? HK na-ebelata ?kwa nke akara ?ka nká na an? ah? d? iche iche.

Na mgbakwunye na ?ka nká eke, nd? nch?p?ta ah? ch?p?takwara na ?gw?gw? HK nwekwara ike igbochi ?ka nká na cardiotoxicity nke ?gw? chemotherapy doxorubicin kpatara, na-ejigide mmet?ta ?gw?gw? ya.

N'ikpeaz?, n'ihi na HK b? ihe nch?k?ta nwere ihe d? iche iche nke ihe ?k?k?, nd? nch?p?ta nyochara ihe nd? a kap?r? ?n? nke na-ar? ?r? mgbochi ?ka nká, na nsonaaz? ya gosiri na ak?k? flavonoid, luteolin (Lut), b? ihe na-ar? ?r? nke HK mgbochi ?ka nká, nke na-eme ka ?ka nká d?kwuo mma site n'?gbanwe mmek?r?ta d? n'etiti p16 na CDK6.

N'?ch?k?ta ?n?, ?m?m? ihe ah? ch?tara ihe sitere n'okike nwere mmet?ta mgbochi ?ka nká nke na-eme ka cell na ?ka nká d?kwuo mma, ihe mgbaàmà nd? met?tara af? d? ka aj? an?, humpback, nch?k?ta nke ihe nr?bama nke ?ka nká na DNA mebiri n'ime an? ah?, na ogologo nd? an?man? d? ogologo.