SAIB (sucrose isobutyrate acetate) b? ?kwa ?gw? na-ar? ?r? d? iche iche. ? b? mmiri mmiri viscous nke a kwadebere site na njikwa esterification nke sugar eke (sucrose) yana acetic acid na isobutyric anhydride. ? b? ngwak?ta na-emep?ta site na distillation na mmep?ta d? ?cha nke ukwuu. Enwere ike iji ya d? ka ihe nt?hap? na-ad?gide ad?gide, ihe mgbaze/ebu na ihe mgbochi iji ?gw? ?j?? eme ihe.

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Njirimara ngwaah?a SAIB

SAIB b? ezigbo ihe mgbaze/ebu maka API hydrophobic ma nwee ?r? nt?hap? nway?.

SAIB ad?gh? kristal ma na-an?gide na-ad?chagh? mma n'ime ?l? okpom?k?, nke na-akwalite mm?ba nke nnyefe ?gw? mgbe niile;

SAIB ab?gh? polymeric na ? nagh? agbak?ta ma ? b? kpalie mgbe ? na-akpak?r?ta na mmiri mmiri. SAIB b? soluble na ?t?t? organic solvents na dak?tara na ?t?t? ihe; Enwere ike ?gbasa SAIB na mmiri site n'enyemaka nke ihe mgbaze organic.

SAIB nwere ak?r?ngwa bioadhesive na enwere ike iji ya maka ngwa transdermal, sublingual na buccal patch.

Ngwa ngwaah?a

1. gbuo oge nt?hap?

Na ?n? ?g?g? d? n'elu, enwere ike ?h? na SAIB nwere uru HLB d? ihe d? ka 5, na-egosi na ? b? hydrophobic.

2. Ogbenye mmiri solubility API ngw?ta

Hydrophobic SAIB b? ezigbo ihe mgbaze / ebu maka API na mmiri solubility na-ad?gh? mma, na iji SAIB na-eme ka ike nke ?gw? nd? na-ad?gh? edozi ah?a.

3. Gbochie iji ?gw? eme ihe

Ojiji SAIB na-abawanye nha nke opioids n'oge a na-egweri ma na-egbochi mm?p?ta ?gw?.

(1) Polymers (polyoxyethylene na / ma ? b? hydroxypropyl methylcellulose) na tocopherol acetate b? granules nke sitere na ngw?ta mmanya nke SAIB. A na-ekewa nkwadebe ah? d? ka nke a na-ad?gh? agw? ?r?a / a na-ad?gh? agw?ta ma ? b? na-ekpo ?k? na-agw? / gw?? (gw?? 90oC maka nkeji 30).

(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene na / ma ? b? hydroxypropyl methylcellulose) na tocopherol acetate b? granules nke sitere na mmanya mmanya nke SAIB. A na-ekewa nkwadebe ah? d? ka nke a na-ad?gh? agw? ?r?a / a na-ad?gh? agw?ta ma ? b? na-ekpo ?k? na-agw? / gw?? (gw?? 90oC maka nkeji 30).

Nt?le mmet? imi na-egosi na ojiji SAIB na-abawanye nha nt? nt? n'oge a na-egweri, yana ihe ruru 47% nke nt? nt? nt? kariri 1mm.

E jiri ya t?nyere nd? na-ah? maka njikwa, ?n??g? mm?p?ta nke SAIB na mmiri, 0.1% N HCl na 0.1% N NaOH solvents belatara site na 41.3% -42.5%, 24.8% -26.1% na 37.4% -50.6%, n'otu n'otu. Ojiji nke ihe mgbaze organic maka mm?p?ta na-emep?ta ihe nd? na-egbu egbu nke siri ike ?gafe n'?z? d? iche iche nke nch?kwa (d?ka ?m?maat?, injection, ingestion, snorting, wdg), na-egbochi iji ?gw? eme ihe.

mmechi

Ojiji nke SAIB, na-enwegh? mkpuchi, nwere ike ?gwak?ta ya na API iji mee ka nt?hap? ?gw? d? ogologo ma nweta nt?hap? na-ad?gide ad?gide.

Hydrophobic SAIB, nke nwere ike gbasaa n'ime mmiri site n'enyemaka nke ihe nd? na-edozi ah?, nwere ike iji hydrophobic ma ? b? hydrophilic apis; SAIB nwere ike melite solubility nke API na mmiri solubility na-ad?gh? mma ma b?r? ezigbo ihe mgbaze na ihe na-ebu maka API na mmiri na-ad?gh? mma.

Iji SAIB na-egbochi iji ?gw? ?j?? eme ihe site n'?ba ?ba uru nke ?gw? ah? mgbe a na-agbanye ya, na-etinye aka na mm?p?ta ?gw?, na-eme ka ? sie ike ?nweta ?gw? ah? site na ?z? nch?kwa d? iche iche.

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