Ike nke mannose na mpaghara ?gw? na-etinyekar? aka n'?t?t? ?z? ak?wap?tara, ?f?d? n'ime ha etinyelar? ?l? ?gw? (d? ka mgbochi ?r?a urinary tract), ebe nd? ?z? n? na nyocha b? isi ma ? b? usoro nyocha ?l? ?gw? mb?. At?manya kwes?r? ??a nt? na ya, mana a ch?kwuru ihe akaebe iji kwado ha. K?waa ikike ya na mpaghara nd? a:

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1, Agh?tara/Tozuru okè Ngwa Ubi

Na-egbochi ?r?a urinary na-emekar? (rUTI) ?

Usoro: nch?kwa ?n? nke mannose na-ebute mm?ba d? elu na mmam?r?, na-as?mpi na-egbochi njik? nke FimH pilin adhesins site na nje nd? d? ka Escherichia coli na eriri afo epithelial cell, na-egbochi nje bacteria ?ch?k?ta na mmam?r? na-asachap? ya.

Ihe akaebe:

?t?t? ?m?m? ?l? ?gw?, d? ka at?nyere ?gw? nje furantoin, egosila na 1.5-2g nke mannose kwa ?b?ch? na-ar? ?r? d? ka ?gw? nje na-ad?gh? ala na-egbochi rUTI nke Escherichia coli kpatara n'ime ?m? nwany?, ma nwee obere ihe ize nd? nke nkw?s?.

Ntuziaka European Association of Urology (EAU) dep?tara ya d? ka ihe ?z? na mgbochi RUTI (?kwa nke akaebe: B).

Uru: Nchekwa d? elu (mmet?ta d? nro nke eriri af?), enwegh? ihe ize nd? nke nguzogide ?gw? nje sara mbara.

Oke: Naan? ?dabara maka mgbochi na enwegh? ike dochie ?gw? nje na ?gw?gw? nke nnukwu ?r?a; Mmet?ta na-ab?gh? Escherichia coli UTI nwere oke.

2. Mpaghara na nyocha ogbo mana nwere ike doro anya

?gw?gw? nke ?r?a Glycation Congenital (CDG)

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Mechanism: ?f?d? ?d? CDG, d? ka MPI-CDG (?d? CDG-Ib), enwegh? phosphomannose isomerase (PMI), nke na-egbochi mgbanwe nke mannose-6-phosphate na fructose-6-phosphate, na-eduga n'?t?t? ak?k? ah?.

?gw?gw?: nch?kwa ?n? nke mannose nwere ike gafere nt?p? PMI ma nye manose-6-phosphate ozugbo, na-eweghachi njik? glycoprotein.

?n?d? d? ugbu a:

FDA akwadola iji mannose maka MPI-CDG, nke b? otu n'ime ?d? CDG ole na ole enwere ike ?gw?ta.

?ganihu d? ?r?ba ama na ?r?a imeju, ar?r? ?r? coagulation, na mgbaàmà eriri af?, mana a ch?r? ?gw? ogologo nd?.

Enwere ike: Ch?ghar?a uru ?gw?gw? adjuvant maka ?d? ?d? CDG nd? ?z?, d? ka ALG-CDG.

Usoro mgbochi mgbochi ?r?a mgbochi na nnyefe ?gw?

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Usoro:

Microenvironment tumor ezubere iche: Tumor jik?tara macrophages (TAMs) nke ukwuu na-anabata mannose receptors (MRC1), na ?gw? emezighar? mannose nwere ike ibunye etuto ah? n'?z? ezubere iche.

Na-ach?kwa mgbochi mgbochi ?r?a: Mannose na-as? mpi na-egbochi nd? na-anabata mannose n'elu TAMs, na-egbochi nnabata ha nke antigens mannose glycated n'elu mkp?r? nd? tumo, nke nwere ike gbanwee nkw?s? ah?.

Ime ka chemotherapy d?kwuo mma: N'?m?m? an?man?, nchikota mannose na chemotherapy (d? ka doxorubicin) nwere ike igbochi uto tumor (ikekwe site na itinye aka na glucose metabolism).

Ihe ?ma aka: Ach?r? nyocha ?z? maka ?d? irè mmad?, usoro ?gw?gw? kacha mma, na usoro nnyefe.

Antifungal/antiparasitic ?r?a adjuvants ??

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Mechanism: ?r?a nd? d? ka Candida albicans na Plasmodium na-adabere na nd? na-anabata mannose nd? ?b?a ka ha wakpo sel. Mannose nwere ike igbochi nrapanye ya.

Nyocha:

In vitro na ?d? an?man? egosila na mannose nwere ike igbochi Candida adhesion na sel epithelial.

Ejik?ta ya na ?gw? mgbochi ?ba nwere ike ibelata ?n??g? nje nje ?ba (nnwale an?man?).

Enwere ike: D? ka adjuvant iji kwalite nr?p?ta ?gw? mgbochi nje d? ad? yana ibelata nguzogide ?gw?.

3, nt?z?aka nyocha na-ap?ta (nwere ike ikwenye)

?r?a af? na-efe efe (IBD) na nr?zi mgbochi eriri af? ??

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Nt?le:

Mannose nwere ike na-ach?kwa eriri af? microbiota (na-akwalite nje bacteria bara uru) ma gbochie nrapagide nke nje bacteria.

Mee ka ?r? nke protein mgbochi eriri af? mucosal d? elu site na mgbanwe glycosylation.

?n?d? d? ugbu a: ?d? an?man? (colitis) na-egosi ?f?d? mmet?ta nchebe, ma nch?p?ta mmad? ad?gh?.

Usoro nke ?r?a autoimmune ??

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Ozizi: Glycosylation na-ad?gh? mma na-etinye aka na pathogenesis nke ?r?a ogbu na nkwonkwo rheumatoid, lupus, na ?r?a nd? ?z?. Mgbakwunye mannose nwere ike mezie nt?p? glycosylation.

?ganihu: A na-ah? ya naan? n'?d? cell ma ? b? ?n? ?g?g? d? nta nke ikpe, na-enwegh? nnwale ?l? ?gw? siri ike.

Mgbochi nsogbu nke ?r?a shuga ??

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Echiche: ?bara d? elu na-eduga n'?ba ?ba nke protein na-ab?gh? enzymatic glycation (AGEs), na-akpata nsogbu. Metabolism Mannose anagh? adabere na insulin ma ? d?gh? emet?ta glucose ?bara, ma ? b? ? nwere ike ibelata nguzobe nke AGE.

Ihe akaebe: Nnwale an?man? na-egosi na ?ganihu nke ?r?a shuga nephropathy na-ebelata, nyocha mmad? enwegh?kwa ohere.

4. Ihe ?ma aka na oke

Isi ihe ?ma aka na ubi

Mgbochi UTI ad?gh? ar? ?r? megide nje nd? na-ab?gh? Escherichia coli; Data nchekwa ogologo oge ezughi oke (kar?s?a mmet?ta ?r? gbasara ak?r?)

?gw?gw? CDG d? irè naan? maka ?d? subtypes ak?wap?tara; Ach?r? nch?p?ta mmalite na ?gw? ogologo nd?

A magh? ?d? irè nke ?gw?gw? tumor na ah? mmad?; Nnukwu doses nwere ike ?kpata af? ?s?sa; ? d? mkpa ka enyocha ihe ize nd? nsi nke ijik?ta chemotherapy

ezugh? oke nke otu ojiji nke ihe mgbochi ?r?a adjuvant; Mkpa ka ebuli ?gw?gw? Nchikota na ?gw? nd? d? ad?

Nnyocha na-ad?gh? ike na usoro na mpaghara nd? ?z? na-ap?ta; Enwegh? ule ?l? ?gw? d? elu; ?t?t? n'ime ha na-an?gide na ?d? an?man? ogbo

5, Future development direction

Mmepe usoro nnyefe nkenke: Chep?ta mannose gbanwet?r? nanocarriers iji kwalite ebumnuche etuto/?nya na-efe efe.

Nkwalite ?gw?gw? ngwak?ta: iji ?gw? nje na-enyocha mmet?ta synergistic nke mannose, nd? na-egbochi mgbochi mgbochi na ?gw? mgbochi.

Mgbasawanye ?r?a na-ad?gh? ah?kebe: Nleba anya maka ?d? CDG nd? ?z? yana nsogbu nchekwa lysosomal nke enwere ike iji mannose gw?? ya.

Usoro nt?hap? na-eme ogologo oge: na-edozi nsogbu nke ?gw? na-emekar? (d?ka iji ya kwa ?b?ch? maka mgbochi UTI).

At?mat? ?n? ?g?g? mmad?: ?gw? ziri ezi dabere na ?d? nje pathogen (UTI) ma ? b? mkp?r? nd? ihe nketa (CDG)