Vitamin B3, nke a makwaara d? ka niacin, b? vitamin na-agbaze mmiri nke na-ar? ?r? d?gas? iche iche d? mkpa n'ime ah?. ?m?m? ihe mb? egosila na vitamin B3 na-ekere òkè na usoro metabolism ike nke an? ah?, na-akwalite metabolism nke mkp?r? nd? akp?kp? ah?, ma nweekwa mmet?ta antioxidant.

?r?a imeju na-ad?gh? egbu egbu (NAFLD), b? ?r?a kachas? elu nke ?d? ?r?a imeju na-ad?gh? ala ala na China, e nwere ihe kar?r? nde nd? ?r?a 150 na China, nke 10-20% ga-enwekwu ?ganihu n'ime steatohepatitis na-ad?gh? egbu egbu (NASH), nke na-egosip?takar? site na mbuf?t na mmebi imeju imeju, na-esonyere fibrosis. NASH na-aga n'ihu ngwa ngwa ma nwee nnukwu ihe ize nd? nke ?malite ?r?a imeju d? nj? d? ka cirrhosis na ?r?a imeju.

N'oge na-ad?begh? anya, nd? na-eme nch?p?ta sitere na ?l? Akw?kw? nke Ah?ike ?ha na Mahadum Sun Yat-sen bip?tara akw?kw? na akw?kw? ak?k? JAMA Network Open nke isiokwu ya b? "Dietary Niacin Intake and Mortality among Individuals With Nonalcoholic. Fatty Liver Disease "akw?kw? nyocha.

?m?m? ihe ah? gosiri na mgbakwunye na vitamin B3, ma ? b? mbelata ihe ize nd? nke ihe niile na-akpata ?nw? na nd? ?r?a nwere ?r?a imeju ab?ba na-ad?gh? a??r?ma, jik?tara ya na mbelata 30% n'ihe ize nd? nke ?nw? na-akpata ?nw? na nd? sonyere na nri kachas? elu (≥26.7mg / ?b?ch?) ma e jiri ya t?nyere nd? na-eso ya nwere obere oriri (≤18.4mg / ?b?ch?).

N'ime ?m?m? ihe a, nd? nch?p?ta nyochara njik? d? n'etiti nri vitamin B3 na-eri nri na ihe ize nd? nke ihe niile na-akpata ?nw? na nd? ?r?a nwere ?r?a imeju na-ad?gh? egbu egbu site n'?ch?k?ta vitamin B3 oriri na-eri nri site na National Health and Nutrition Examination Survey (NHANES) nchekwa data nke nd? ?r?a 4,315 NAFLD na nkezi af? 53.

E kewara nd? sonyere n'ìgwè at? dabere na vitamin B3 oriri: obere oriri (≤18.4mg / ?b?ch?), ?kara oriri otu (18.5-26.6mg / ?b?ch?) na nnukwu oriri otu (≥26.7mg / ?b?ch?).
N'ime oge nleba anya nke af? 8.8, ng?k?ta nke ?nw? 566 ka edere, 197 n'ime ha b? ?r?a obi.

Nnyocha ah? ch?p?tara na nd? na-eso ya nwere ihe oriri kachas? elu nwere ihe ize nd? d? ala nke pasent 30 nke ihe kpatara ?nw? ma e jiri ya t?nyere nd? na-eri nri kacha ala.

T?kwas? na nke ah?, nd? na-eso ya nwere ihe oriri kachas? elu nwere mbelata pasent 35 n'ihe ize nd? ?nw? nke obi, ma nke a ab?gh? ihe ndek? ?n? ?g?g?.

Nnyocha nd? ?z? ch?p?tara mmek?r?ta d? ?r?ba ama n'etiti vitamin B3 oriri na ihe ize nd? nke ?r?a shuga na ihe niile na-akpata ?nw?, na mbelata ka ukwuu nke ?nw? na nd? ?r?a na-ab?gh? nd? ?r?a mam?r? ma e jiri ya t?nyere nd? nwere ?r?a shuga.

D? ka nd? nch?p?ta si kwuo, niacin b? otu n'ime ihe mmalite nke njik? NAD ma b?r?kwa ihe d? mkpa maka igbochi na ?gw?gw? ?r?a imeju. ?m?m? ihe gbasara enyemaka nd? mmad? egosikwala na niacin nwere ike melite imeju nwere ab?ba ma belata ?d?naya imeju. N'ime ?m?m? ihe izizi, a ch?p?tala niacin na-egbochi ma na-at?ghar? steatosis imeju na mbuf?t, ma gbochie fibrosis. A na-enweta mmet?ta nd? a site na ibelata nr?gide oxidative, igbochi diacylglyceryl acyltransferase 2 na NADPH oxidase ?r?, na usoro nd? ?z? nwere ike ime.

? bara uru ?k?wa na na Septemba 2023, nd? nyocha sitere na ofl? Akw?kw? nke Ah?ike ?ha na Mahadum Sun Yat-sen bip?tara akw?kw? n'akw?kw? ak?k? Nutrients nke isiokwu ya b? "Mmek?r?ta n'etiti Dietary Niacin Intake na ?r?a imeju na-ad?gh? egbu egbu: NHANES 2003-2018 "akw?kw? nyocha.

?m?m? ihe ah? gosiri na mgbakwunye vitamin B3 jik?tara ya na obere ihe ize nd? nke ?r?a imeju ab?ba na-ad?gh? egbu egbu, yana nd? nwere niacin kachas? elu (≥29.2mg / ?b?ch?) nwere ihe ize nd? d? ala 31% nke ?r?a imeju ab?ba na-ad?gh? egbu egbu ma e jiri ya t?nyere nd? nwere niacin kacha nta (≤16.3mg / ?b?ch?).

N'?ch?k?ta ?n?, nsonaaz? ya na-egosi na mgbakwunye vitamin B3 na-ejik?ta ya na obere ihe ize nd? nke ?r?a imeju na-ad?gh? egbu egbu na mbelata ihe ize nd? nke ihe niile na-akpata ?nw? na nd? ?r?a nwere ?r?a imeju na-ad?gh? egbu egbu. A ch?r? nyocha ?z? iji kwado vitamin B3 kacha mma iji belata ihe ize nd? nke ?nw? na-akpata ?nw? na nd? ?r?a nwere NAFLD.