?r?a imeju na-egbu egbu (ALD), nke b? ?r?a imeju nke ???biga mmanya ókè na-ebute ogologo oge, b? otu n'ime ?r?a imeju na-emekar? na China, g?nyere imeju na-egbu egbu, ?ba ?cha n'anya, ?r?a imeju na-egbu egbu na ?r?a cirrhosis na-egbu egbu. N'af? nd? na-ad?begh? anya, ?n? ?g?g? nke ?r?a imeju na-egbu egbu egosiwo na-ar?wanye elu na-emekar? na China.

Na Jula? 2, 2024, Liu Zhihua nke Mahadum Tsinghua, Wang Hua nke Mahadum Ah?ike Anhui, Yin Shi nke Mahadum Sayens? na Tekn?z? nke China na nd? nch?p?ta nd? ?z? bip?tara otu isiokwu isiokwu ya b? "Fiber erimeri na-ebelata mmer? ah? imeju mmanya na-egbu egbu site na" na akw?kw? ak?k? Cell Host & Microbe "Bacteroides acidifaciens na ammonia deditoxification".

Ach?p?tara nri bara ?ba na eriri nri soluble iji mee ka ?bara nke B. accidifaciens belata ma belata mmer? ah? nke mmanya na-akpata na ?m? oke.

Na usoro, B.accifaciens na-ach?kwa bile acid metabolism site na bile saline hydrolysis enzyme (BSH). Mm?ba nke bile acid na-ejik?tagh? ?n? na-eme ka ?z? FXR-FGF15 d? na eriri af?, na-echebe ?r? mgbochi eriri af?, na-akwalite nkwup?ta nke ornithine aminotransferase (OAT) na hepatocytes, ma si otú a na-akwalite metabolism nke akwak?ba ornithine na imeju ka glutamate. Nye ak?r?ngwa maka imeju detoxification ma belata mmebi mkp?r? nd? imeju.

?m?m? ihe a, nd? nch?p?ta bu ?z? bute ?r?a imeju mmanya na-egbu egbu n'?d? òké wee nyochaa mmet?ta nke eriri nri na ?r?a imeju na-egbu egbu na ?m? oke site n'?gbakwunye ma eriri soluble na nke na-ad?gh? ike.

Nsonaaz? ach?p?tara na mgbakwunye eriri nri soluble mere ka ?r?a imeju na-egbu egbu ka mma na ?m? oke, g?nyere ibelata steatosis imeju na ibelata pasent na ?n??g? neutrophils imeju, ebe eriri nri na-enwegh? ike ime enwegh? mmet?ta d? ukwuu.

N'ihi na eriri nri nwere ike imet?ta eriri af? microbiota nke ukwuu, nd? nyocha ah? nyochara ma mm?ba nke ?r?a imeju mmanya na-aba n'anya sitere na eriri af? microbiota site na usoro nt?ghar? microbiota.

Mgbe transplant, a ch?p?tara na transplanting microflora nke ?m? oke nri soluble nri fiber belatara serum alanine aminotransferase (ALT) na aspartate aminotransferase (AST), na-ebelata imeju steatosis na mbuf?t etoju, na-at? aro na soluble nri eriri nwere ike imet?ta mmepe nke ALD site reshaking mejup?tara nke eriri af? microflora.

The ?m?m? gosiri na soluble dietary eriri mma imeju cell necrosis, imeju steatosis na mbuf?t na òké nlereanya nke mmanya imeju ?r?a, na-ebelata ?bara amonia lar?? na oxidative nchegbu, p?ta ìhè ?r? d? mkpa nke soluble dietary eriri na mgbochi na ?gw?gw? nke a??r?ma ?r?a imeju.

? d? mkpa iburu n'obi na a na-at? aro nd? okenye ka ha rie gram 25-30 ma ? b? kar?a nke eriri nri kwa ?b?ch?, mana ?t?t? nd? anagh? emezu nd?m?d? nri. Mkp?r? ?ka, mkp?r? osisi na akw?kw? nri b? isi mmalite nke eriri nri ma nwee ike inye micronutrients nd? ?z? d? mkpa.

Na nch?k?ta, nsonaaz? ya na-at? aro na nri bara ?ba na eriri nri soluble nwere ike imezi mmer? imeju mmanya na-akpata na ?d? òké ma na-echebe iguzosi ike n'ezi ihe nke mgbochi eriri af?. ?m?m? ihe a nwere ?f?d? uru ?l? ?gw? na mkpa ?haneze.

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