Nnyocha mb? egosila na vitamin C nwere uru ah?ike d? iche iche, g?nyere usoro ah? ji al?so ?r?a ?g?, mmet?ta antioxidant, na ah?ike obi. ? b? ezie na vitamin C b? ihe d? mkpa na-edozi ah? maka ?n?gide na-enwe ah? ike, oke ma ? b? nke d? ntak?r? nwere ike inwe mmet?ta ?j?? na ah? ike.

Melanoma (MM) b? akp? na-ad?gh? mma nke na-esite na mkp?r? nd? nwere pigmenti nke akp?kp? ah? ma b?r? ?d? ?r?a cancer akp?kp? an? kachas? d? ize nd?, n'agbanyegh? na ? nwere obere ?n?d? ma na-eme ihe ike na metastatic. Mmet?ta nke melanoma an?wo na-ar? elu n'ime iri af? ole na ole gara aga.

N'oge na-ad?begh? anya, nd? nch?p?ta sitere na Mahadum South Florida d? na United States na Mahadum Leicester d? na United Kingdom bip?tara akw?kw? nke isiokwu ya b? "Redox modulation of oxidatively-induced DNA damage by ascorbate enhances" na akw?kw? ak?k? Free Radical Biology and Medicine ma in vitro na ex-vivo DNA mmebi guzobe na cell ?nw? na melanoma cell ".

Nnyocha e mere egosiwo na ?gw? mkp?r? nd? cancer nke melanoma na vitamin C nwere ike ime ka DNA mebiri emebi oxidant na mkp?r? nd? kansa ma kwalite ?nw? mkp?r? nd? kansa, na mmebi a dabara na ?n??g? nke melanin d? na sel. Na maka mkp?r? nd? akp?kp? an? nk?t?, ? na-ar? ?r? nchebe.

N'ime ?m?m? ihe a, nd? nch?p?ta ah? guzobere otu ah?r? MM cell nwere agba d? iche iche, jiri hydrogen peroxide d? ka ihe at? oxidant, wee nyochaa vitamin C iji mee ka ohere nke igbu egbu melanoma d? site na ?kwalite mmebi DNA nke oxidation kpatara.

Nd? nch?p?ta ah? nwalere ?kwa nke vitamin C na-akpata DNA mebiri na ah?r? sel ise wee ch?p?ta na e jiri ya t?nyere sel an? ah? nk?t?, keratinocytes (HaCaT), ?kwa nke mmebi DNA nke endogenous na-ad?kar? elu na sel MM niile, iji mebie ?d? nj?: SK23 mkp?r? nd? nwere pigmentation d? elu, mkp?r? nd? SK28 nwere pigmentation na-agafegh? oke, A375M, na-enwegh? sel ha375. DNA mebiri.

T?kwas? na nke ah?, nd? nch?p?ta ah? nyochara uche nke ah?r? mkp?r? nd? ise iji mebie ihe oxidant (hydrogen peroxide) kpatara wee ch?p?ta na mmebi mmet?ta nke hydrogen peroxide kwek?r? na nke d? n'elu.

Nt?le ?z? nke ?d? oxidative intracellular gosip?tara na mkp?r? nd? MM gosip?tara ?kwa d? elu nke endogenous nke ?d? oxidative intracellular kar?a mkp?r? nd? HaCaT, na usoro nke ah?r? sel ise kwek?r? na mmebi DNA, mmebi mmet?ta, na cytopigmentation.

Na-esote, nd? nch?p?ta ah? mesoro mkp?r? nd? ah? ma ? b? na-enwegh? vitamin C wee nyochaa mmet?ta nch?kwa nke vitamin C nwere na mmebi DNA na-akpata oxidation na igbu mmad?.

Nsonaaz? gosiri na maka mkp?r? nd? MM niile, ?kwa nke mmebi DNA endogenous nke ?gw?gw? vitamin C kpatara na-abawanye nke ukwuu, ebe nke mkp?r? nd? HaCaT ab?gh? ihe d? mkpa, na mmebi DNA na-akpata na-adaba adaba na nke d? n'elu.

Na mgbakwunye, ?kwa nke vitamin C na-ebute nucleobase mebiri b? nke kachas? elu na sel SK23 nwere pigmenti nke ukwuu (18.5%) na nke kachas? ala na sel A375P na-ab?gh? pigmented (14.2%).

Dabere na eziokwu ah? b? na vitamin C nwere ike ?kwalite mmebi nke DNA endogenous peroxide na mmebi nucleobase na sel MM, nd? nyocha ah? nyochakwara mmet?ta vitamin C na DNA ab?? strand breaks wee ch?p?ta na maka sel MM niile, ?kwa nke DNA ab?? strand mebiri site na ?gw?gw? vitamin C m?bara nke ukwuu, mana ? b?gh? maka mkp?r? nd? HaCaT. Usoro nke ah?r? cell ise ka na-adaba na nke d? n'elu.

N'?z? d? mkpa, nd? nch?p?ta nyochara ma vitamin C kwalitere peroxid-induced MM cell ?nw?, wee ch?p?ta na vitamin C kwalitere igbu egbu peroxid nke sel MM niile, ebe ? na-ar? ?r? nchebe na mkp?r? nd? HaCaT, na usoro igbu egbu kwek?r? na nke d? n'elu.

N'ikpeaz?, ?m?m? ah? ch?p?takwara na vitamin C nwere ike ?kwalite nr?p?ta nke melanoma ?gw? Elesclomol d? ugbu a, na-eme ka mmebi DNA nke mkp?r? nd? cancer na-ebute site na Elesclomol.

Nd? ?r? nyocha ah? kwuru na iji vitamin C, nke nwere ike ?bawanye mmebi DNA na mkp?r? nd? kansa ma bute ?nw? mkp?r? nd? kansa, nwere ike b?r? ?z? d? irè isi gw?? melanoma, nke ka ch?r? nyocha ?l? ?gw? na nnwale iji ch?p?ta.

Nyere na a m??la vitamin C nke ?ma ma mara na ? na-anabata ya nke ?ma, nd? nch?p?ta ah? kwenyere na nd? d?k?ta nwere ike iji vitamin C d? ka mgbakwunye iji kwalite ?gw?gw? nd? d? ugbu a.

Ejik?tara ?n?, ihe ?m?m? in vitro a na-egosi nke ah?vitamin Cnwere ike ?kwalite mmebi DNA nke na-akpata oxidation, na-akwalite ?nw? mkp?r? nd? kansa, ka ? na-ar? ?r? nchebe na sel an? ah? nk?t?, ma kwalite nr?p?ta nke ?gw? melanoma d? ugbu a, nke kwes?r? ?m?kwu ihe.