Prostate cancer (PC), otu n'ime ?r?a cancer na-ah?kar? na ?m? nwoke, d? ka onye na-egbu ?n?, na ?t?t? nd? ?r?a na-enwe mgbaàmà na-eto ngwa ngwa nke ?r?a nke nwere ike imecha gh?? ?r?a cancer na-eyi nd? egwu. N'oge ah?, ?r?a cancer prostate nwere ike ?gh? nke na-ad?gh? agw? agw? nke na nh?r? ?gw?gw? niile d?n? anagh? anabata ya.

D? ka a na-ekwu, ?gw?gw? na-adabere na "isi at? nke ?gw?, isi ihe asaa nke nlek?ta", nke a "na-edozi" ?t?t? oge na-ezo aka na tonic nri. ?r?a prostate b? ?r?a na-aga n'ihu na-ad?te aka. ? b?r? na enwere ike ?nakwere ?z? ntinye aka kwes?r? ekwes?, d? ka ibi nd? ezi uche d? na ya na nri, na mmalite nke ?r?a ah?, ? nwere ike igbu oge ?ganihu nke ?r?a cancer prostate n'?z? d? irè ma melite prognosis nke nd? ?r?a.

Na ?ktoba 25, 2024, otu Pr?fes? Lloyd Trotman nke Cold Spring Harbor Laboratory bip?tara na akw?kw? ak?k? ag?makw?kw? mba ?wa kachas? elu nke Sayens? akp?r?: Dietary pro-oxidant therapy site na precursor vitamin K na-ach? akw?kw? nyocha ?r? PI 3-kinase VPS34.

Nnyocha ach?p?tala na mgbakwunye pro-oxidant, menadione (vitamin K3), nwere ike belata ?ganihu nke ?r?a kansa prostate. Menadione b? precursor nke mmiri soluble nke vitamin K, nke a na-ah?kar? na akw?kw? nri akw?kw? nd? akw?kw? nd?, yana ?r? physiological ya b? nke kachas? ?kwalite mkp?k? ?bara na isonye na metabolism ?kp?kp?.

?m?m? usoro egosila na VPS34 b? isi ihe mgbaru ?s? nke phosphatidylinositol 3-kinase (PI3K), menadione nwere ike igbochi ?r? VPS34, belata mmep?ta nke PI3P, ma mee ka nr?gide oxidative na-eduga na ?nw? nke mkp?r? nd? cancer prostate. N'?z? d? iche, mkp?r? nd? nk?t? na-eto nway?? nway??, ya mere ha nwere ikike zuru oke iji nagide mmebi a. Na mgbakwunye, otu nyocha ah? gosip?tara na menadione nwekwara mmet?ta ?gw?gw? na ?r?a mkp?r? nd? na-egbu egbu nke a na-akp? X-linked myotubulin myopathy (XLMTM).

Nch?p?ta nd? a na-ekpughe ?z? d? mfe ma d? irè isi tinye aka na ?r?a cancer ma nwee mmet?ta ?h?r? maka ?gw?gw? ?r?a mkp?r? nd? ihe nketa nd? ?z? kpatara dysregulation nke kinase ?r?.

Nd? otu ah? mesoro ?d? mouse RapidCaP na mgbakwunye pro-oxidant, menadione sodium sulfite (MSB), ogige nke b? ihe na-ebute mammalian na vitamin K. Ha ch?p?tara na mgbakwunye MSB kwa ?b?ch? na mmiri ????? nwere ike igbochi ?ganihu nke ?r?a cancer prostate ma mep?ta mmet?ta mgbochi na-ad?gide ad?gide.

N'ozuzu, ?m?m? ah?, nke e bip?tara na Sayens?, na-at? aro na ?gbakwunye pro-oxidant supplements na nri iji gbakwunye MSB nwere ike igbu oge ?r?a ?r?a cancer prostate n'?z? d? irè. Nke a b? n'ihi na MSB nwere ike igbochi ?r? PI3K kinase VPS34, belata mmep?ta nke PI3P, na ?bawanye nr?gide oxidative, nke na-eduga na ?nw? nke mkp?r? nd? cancer prostate. T?kwas? na nke ah?, na X-linked myotubular myopathy (XLMTM), MSB nwere ike igbochi ?r? kinase nke VPS34, na-eweghachi PI3P na ?kwa nd? nwere ike imeziwanye mmepe ah?.