Sucralose b? ihe nn?chi shuga. ? b? ihe ?t? artificial na-ejikar? eme ihe. Nd? mmad? na-enwekar? mmas? na ihe nd? na-edozi shuga n'ihi na ha na-enye ?t? mana ha enwegh? ?d?naya kalori d? na shuga teb?l. A na-ejikar? Sucralose eme ihe d? ka ihe mgbakwunye na nri na ihe ?????, a na-erekar? ya d? ka "enwegh? shuga" ma ? b? "mbelata ibu" iji belata oriri calorie n'ozuzu ya.

Kedu ihe b? sucralose?

Sucralose b? ihe a na-ejikar? eme ihe na-ad?gh? edozi ah?, ihe ?t? na-at? ?t? na-enwegh? kalori. A na-emep?ta Sucralose n'?z? artificially site na shuga teb?l (sugar teb?l) site na usoro ?t?t? usoro nke na-ah?r? at? nke hydroxyl n'ime molekul shuga na at? chlorine at?. N'ikpeaz?, a sachara ya ihe d?ka 98%. Mgbanwe kem?kal? nd? a na-ach?p?ta na sucralose d? ihe d? ka ugboro 600 ?t? kar?a shuga teb?l. Ngwaah?a ikpeaz? b? ihe na-acha ?cha, kristal, ihe ?t? artificial na-ar? ?r? nke ?ma nke na-agbaze na mmiri. Nnukwu solubility nke Sucralose na mmiri na-eme ka ? d? mma maka itinye n'ime ?d? nri a na-esi nri d? iche iche: ngwaah?a esiri esi, ihe ?????, ch?ng?m, gelatin, na desserts mmiri ara ehi oyi kp?nw?r?. Nd? mmad? n'otu n'otu na-ach? ihe ?t? ?z? na-ah?r?kar? sucralose kar?a ihe ?t? nd? ?z? d? ka aspartame na saccharin. D? ka ihe na-esi na teb?l shuga, sucralose na-ejigide ?t?t? ?t? "sugar-d? ka" ? maara nke ?ma, ebe ? na-enwegh? isi ?t? na-at? ?t? nke nd? ?z? dochie shuga. ?t? d? ike nke sucralose na-enye ohere ka obere ego na-aga ogologo oge, na-eme ka ? b?r? nh?r? na-ewu ewu maka nri obere kalori. Mm?ba nke sucralose n'ime eriri af? d? ntak?r?, na ?z? mgbap? b? isi sucralose na-agbanwegh? na stool. Ya mere, ? d?gh? usoro catabolic (ndabi), na-akwado na sucralose ab?gh? isi iyi nke ume na / ma ? b? calorie. ?n?d? nkwado na ?kp?r? sucralose b? nke mb? kwadoro maka ojiji na Canada na 1991, sochiri Australia na 1993 na New Zealand na 1996. Na 1998, US Food and Drug Administration (FDA) kwadoro sucralose maka ojiji na 15 nri na ihe ????? edemede, na gbasaa ya iji d? ka a n'ozuzu-nzube na sweet19. mgbakwunye na European Union na 2004. FDA na-ach?kwa sucralose d? ka ihe mgbakwunye nri. N'okpuru Iwu nri, ?gw? na ?ch? mma g??menti etiti, ihe ?t? ga-ad? mma maka iri nri. Mkpebi nchekwa nchekwa FDA gbadoro ?kw? na nyocha an?man? buru ibu na nnwale ?l? ?gw? nke na-enyocha toxicology, teratogenicity (ikike ?kpata mmebi nke nwa ebu n'af? n'oge ime ime), na carcinogenicity. Dabere na nd?m?d? FDA, ?kwa nke sucralose a na-anabata kwa ?b?ch? (ADI) ka edobere na 5 mg / kg ar? ah? kwa ?b?ch? (mg / kg / ?b?ch?). Uru nwere ike iji sucralose maka njikwa ibu na-enwegh? kalori

N'ad?gh? ka shuga teb?l, sucralose anagh? agbaze ma ? b? gbajie ya na eriri af? ma ? nagh? ar? ?r? d? ka mman? caloric na ah? any?. Ya mere, Sucralose b? nh?r? a ma ama maka nd? na-ach? iji dochie shuga shuga (1 teaspoon ma ? b? ihe d? ka gram 4.2 nke teb?l shuga nwere calorie 16) ma belata mkpok?ta kalori oriri. Site na itinye sucralose na nri ha, nd? mmad? nwere ike gboo mkpa ha d? ?t? na-enwegh? ichegbu onwe ha maka calorie nd? ?z?, nke d? mkpa maka njikwa ibu.

Kwes?r? ekwes? maka njikwa ?r?a shuga

Sucralose ad?gh? metabolized site na ah? any? maka ume yana ? nagh? ebute mm?ba nke ?kwa shuga ?bara (6). Dabere na nyocha ?l? ?gw? nke sucralose na nd? nwere ?r?a shuga, FDA ekpebiela na sucralose anagh? emet?ta njikwa shuga ?bara d? mkp?mkp? na nd? nwere ?d? ?r?a shuga 2. Na mgbakwunye, usoro ?m?m? ?l? ?gw? egosila na sucralose anagh? emet?ta glucose homeostasis ogologo oge (d? ka elele HbA1c glycosylation) na nd? ?r?a nwere ?d? ?r?a shuga 2. Ya mere, sucralose b? nh?r? na-at? ?t? maka nd? ?r?a mam?r? na-ejigide nri nwere obere carb. Agbanyegh?, d? ka ? d? na nh?r? nri ? b?la, nd? nwere ?r?a shuga kwes?r? ?kp?t?r? onye na-ah? maka njik?ta ma ? b? na-ar? ?r? maka usoro nri ahaziri iche ka ha na-elele ihe egwu hypoglycemia sitere na oriri sucralose. Nsogbu ah?ike nwere ike ime na mmet?ta d? n'ak?k? ? b? ezie na enyochala sucralose maka nchekwa site n'aka nd? na-ach?kwa, nchekwa nke sucralose na mmet?ta ah?ike ya nwere ike ?r? ?ka. Kar?s?a, ?m?m? ihe na-egbu egbu na-enyocha mmet?ta nke nch?kwa glucose, neurotoxicity, na carcinogenicity na ?m? an?man? na-ebutekar? ?k? nk?.

Nnyocha egosiwo na ihe ?t? artificial, g?nyere sucralose, na-akpali mmep?ta insulin site na nd? na-anabata ya d? ?t? gosip?tara na mkp?r? nd? beta na pancreas, ?kachas? na enwegh? glucose. E gosiputara Sucralose na-ebute ihe nzuzo nke GLP-1. GLP-1 d? mkpa maka glucose homeostasis na n'ozuzu na-eme ka insulin na-eme ka glucose d? n'?bara. Ka oge na-aga, mm?ba insulin n'?bara mgbe ekpughere ya na sucralose nwere ike mechaa bute nguzogide insulin n'ihi mbelata ?r? nnabata. Mmebi glucose homeostasis (nhazi ?kwa shuga d? n'?bara) yana mbelata mmet?ta insulin b? njirimara nd? b? isi jik?tara ya na nsogbu metabolic. Enwegh? ike ? nwetaghachi glucose n'?z? d? irè na-akpaghas? usoro shuga ?bara ma na-eduga na mmepe nke ?r?a metabolic na-esote d?ka ?r?a shuga 2, oke ibu, na dyslipidemia. Na mgbakwunye, ihe ize nd? nke ?malite ?r?a obi na-abawanye nke ukwuu. A na-ah?ta mmet?ta na ah?ike eriri af? na microbiome Sucralose d? ka "inert metabolically" n'ihi na ? nagh? etinye ya n'ah? mana ? na-ewep? ya na stool. Nke a na-eme ka o yikar?gh? ka ? b?r? mkp?r? maka microbiome gut. Agbanyegh?, enwere ihe akaebe na mkpughe sucralose nwere ike gbanwee microbiota gut any? n'?z? na-edogh? anya site na njikwa shuga ?bara na-ad?gh? mma ma ? b? nzaghachi nwere ike ?gbagha. ?t?t? ?m?m? an?man? egosila na oriri nke ihe ?t? na-ad?gh? edozi ah? (NNS) nwere ike ?kpata ?r?a microbiome nsia; Na-egosi mm?ba nke nje bacteria na-akpata ?r?a na mbelata nke ukwuu nke nje bacteria bara uru. Otú ? d?, a ga-eji nlezianya mee nke ?ma iwep?ta data an?man? na ?m? mmad?, n'ihi na ?dabara ha na ah?ike mmad? na ?r?a nwere ike ?d? oke. Nnwale ?l? ?gw? emebere iji nyochaa nsonaaz? nke obere oge (at? anya ak?r? ?b?ch? iri na an?) oriri sucralose na metabolism glucose nyochakwara nsonaaz? nke ?ri NNS ugboro ugboro kwa ?b?ch? na microbiota gut. ?m?m? ihe ah? kwubiri na sucralose emegh? mgbanwe d? ukwuu na ?bara microbiota ma ? b? ?nyà. N'aka nke ?z?, nnwale ?z? a na-ach?kwa nke oge d? mkpirikpi gosip?tara na mgbakwunye nri na NNS nwere ike imet?ta ikike ?r? nke microbiome mmad?, yana sucralose nwere mmet?ta kachas?. Otú ? d?, ? d? mkpa iburu n'obi na ma ule ?l? ?gw? nyochara mmet?ta nke obere oge NNS supplementation (g?nyere sucralose), na ogologo oge ikpughe d? mkpa iji gh?ta nke ?ma mmet?ta ah?ike nke NNS supplementation na ?m? mmad? gut microbiome. Mmet?ta ogologo oge nke sucralose na NNS nd? ?z? na microbiome gut mmad? b? mpaghara nyocha na-aga n'ihu.

Ak?k? akwara ozi na usoro ag?? n'agbanyegh? na a na-ewere sucralose enwegh? kalori, ? na-akpali nd? na-anabata uto ?t?, na-akpali insulin secretion na pancreas, wee malite cascade nke metabolic nke na-e?omi ?n?d? iri nri. ? b?r? na enwegh? glucose, insulin na-agbap?ta mgbe niile na-emeghar? nguzozi metabolic na kem?ka ?b?r? any?. A na-agh?gbu ihe ?t? any? n'obi iche na any? na-eri ezigbo shuga. N'ime nnwale crossover enwegh? usoro, ?m? nwany? sonyere na oke ibu gosip?tara mm?ba na mpaghara ?b?r? met?tara nzaghachi nri nri na nhazi ?gw? ?r?, na-eduga n'?ba ?ba caloric oriri na-eso nri sucralose. ?m?m? ihe a na-enye ihe akaebe gbara ?kp?r?kp? na-ejik?ta oriri nke sucralose na ihe ?t? nd? ?z? na-eme ka ag?? na-ag?si ike, iribiga ihe ókè na oke ibu na-esote.