D-mannose na L-mannose b? enantiomers na-egosip?ta ibe ha, na ?d?iche ha d? mkpa na-adabere na nhazi stereoconfigurations ha d? iche iche, na-ebute ?r? na ?r? d? iche iche nke ndu. Nd? na-eson? b? isi ihe ach?p?tara:

?

1. Esemokwu d? mkpa na nhazi kem?kal?

Isi ihe nd? a na-ah?kar?:

Usoro molek?la b? C ? H ?? O?, nke b? C-2 isomer nke glucose (ya b?, hydroxyl (- OH) direction na carbon nke ab?? na-emegide glucose).

Isi nd?iche:

Usoro ntinye aha D/L dabere na usoro nt?nye glyceraldehyde:

D-Mannose: Ntuzi hydroxyl (- OH) nke carbon chiral kacha elu (C5) na molecule dabara na D-glyceraldehyde (nke d? n'ak?k? aka nri na am?ma Fischer).

L-mannose: Ntuziaka hydroxyl nke C5 kwek?r? na nke L-glyceraldehyde (nke d? n'ak?k? aka ekpe na am?ma Fischer).

Ha ab?? b? ihe oyiyi enyo nke ibe ha na enwegh? ike ?gbak?. ;

?

Nt?le ntule Fischer: nt?nyere nhazi n'etiti D-mannose (aka ekpe) na L-mannose (n'aka nri)

?

2. ?r? ndu na ?d?iche metabolic

Njirimara D-mannose L-mannose

?d? ad? n'okike ? Na-ad? n'okike (na mkp?r? osisi, osisi, glycoproteins)

Ihe omume ndu ? nwere ?r? ndu d? egwu

Metabolic ?z? nwere ike ?b? phosphorylated site mannose kinase (MK) na-ap?gh? ?mata site mmad? metabolic enzymes (enzymes nwere chiral kp?mkwem)

?r? an? ah? g?nyere njik? glycoprotein, mgbochi UTI, ?gw?gw? CDG, wdg

? f?r? nke nta ka ? b?r? enwegh? mmet?ta na shuga ?bara (n'ihi na etinyegh? ya / metabolized)

Kedu ihe kpatara D-?d? b? naan? ?d? na-ar? ?r? nd?? ;

Enzymes na nd? na-ebughar? n'ime ihe nd? d? nd? nwere nk?wa chiral siri ike (stereoselectivity):

?

Nch?p?ta enzyme metabolic:

Mannose kinase (MK) na imeju mmad? na-amata na phosphorylates D-mannose na enwegh? ike ime ihe na L-isomer.

Nk?wa nd? njem:

Nd? na-ebughar? glucose intestinal (d? ka GLUT5) na-ebufe D-mannose ?kachamma (n'agbanyegh? na ? d? obere ar?m?r?), ebe L-mannose enwegh? ike itinye uche nke ?ma.

Njide nnabata:

Ebumnuche d? ka onye na-anabata mannose (MRC1) na nje FimH adhesins na-ejik?ta kp?mkwem na D-mannose ma ? b? usoro ya (d? ka D-mannoside).

4. Enwere ike iji L-mannose mee ihe

N'agbanyegh? enwegh? ?r? ndu, L-mannose nwere uru ak?wap?tara na nyocha sayens? na ?l? ?r?

?

Nnyocha biochemical:

D? ka ihe nt?aka maka D-mannose, a na-eji ya m?? usoro njirimara chiral nke enzymes.

Ngwak?ta kem?kal? etiti:

A na-eji ya maka imep?ta shuga d? ?k? ma ? b? ?m? irighiri ?gw? chiral.

Nhazi mgbochi:

Nwere ike r?? ?r? d? ka ihe mgbochi as?mpi maka ?f?d? enzymes (ch?r? nkwado ezubere iche).

Ngwa p?r? iche:

Ejiri ya maka ?kwado polymers chiral ma ? b? nanomaterials (d? ka sens? chiral).

Nch?k?ta igodo

Nt?nyere ak?k? D-mannose L-mannose

Ihe d? mkpa kem?kal? nke isomers aka nri nke d? na okike, nd? isomers aka ekpe ejiri aka ekpe mebere.

Metabolism nke nd? ? Enwere ike metabolized site na enzymes mmad? ? Enzyme mmad? enwegh? ike ?mata ya.

?r? physiological glycosylation, mgbochi ?r?a, ?gw?gw? nke ?r?a na-ad?gh? ah?kebe ? d?gh?

?gw? bara uru etinyere (Mgbochi UTI, ?gw?gw? CDG), ihe mgbakwunye nyocha ihe oriri na-edozi ah?, etiti njik? kem?kal?

?gw? d? elu nwere ike ibute af? ?s?sa (mana n'ozuzu ya ad?gh? mma), anagh? egbu egbu ma ? b?gh? ihe d? nd?

Ebe nchekwa d? mfe:

?

D-type = "?d? ar? ?r? nd?": ? d? na okike, enwere ike ?meghar? ya ma nwee ngwa bara uru.

?d? L-?d? = "?d? njikwa enyo": ar?p?tara n'?z? artificially, na-enwegh? ?r? ndu, na-eji naan? maka nyocha sayens? ma ? b? injin?a kem?kal?.

Okwu 'mannose' nke a kp?t?r? aha na ngalaba ?gw? na nri na-edozi ah? na-ezo aka na D-mannose. L-mannose enwegh? uru ngwa ?l? ?gw?, mana d?ka ngwa kem?kal?, o nwere ?f?d? ikike nyocha sayens?.