0102030405
Kedu ihe kpatara mannitol ji ar? ?r? maka ?r?a urinary tract
2025-03-13
- Mannose (ma ? b? D-Mannose) b? shuga d? mfe, mana n'ad?gh? ka glucose, mannose ad?gh? am?k?r? ngwa ngwa n'ah? ah? mgbe ? ris?r? ya, na pasent 90 nke mannose na-esi na mmam?r? p?ta ozugbo ihe d? ka nkeji 30 ruo 60 mgbe ? were ya, yab? n'ad?gh? ka glucose, mannose ad?gh? emet?ta shuga ?bara, kama ? na-etinye uche na mmam?r?. Mannose nwere ike igbochi glucose metabolism, na-egbochi itinye ab?ba, na-ach?kwa ah?h?a eriri af? yana sonye na nhazi usoro mgbochi. Ngh?ta zuru oke nke usoro omume nke mannose na ?gw?gw? ?r?a nd? met?tara ya b? isi ihe na-eme ka ? gbasaa ngwa ?l? ?gw?.N'af? nd? na-ad?begh? anya, enweela ?t?t? ?m?m? banyere mannose. Taa, any? ga-at?le ma mannose nwere mmet?ta ? b?la na ?gw?gw? ?r?a urinary tract. ?r?a urinary tract b? ?r?a nke nje na-ebute nje na ak?k? ah? ? b?la d? n'okporo ?z? urinary, g?nyere ak?r?, ureter, eriri afo, urethra, wdg, mana ?r?a urinary na-ejikar? eriri afo na urethra. N'ihi ?d?iche an? ah? d? n'etiti nwoke na nwany?, ?m? nwany? nwere ohere d? elu nke ?r?a urinary tract kar?a ?m? nwoke. Nnyocha na-egosi na ?m? nwany? nwere ohere pasent 50 nke ibute ?r?a urinary tract n'oge nd? ha, na n'etiti otu ?z? n'?z? at? na ?kara nke nd? butere ?r?a ah? ga-ebute ?r?a n'ime otu af?.Kemgbe 1980s, nd? d?k?ta na-ar? ?r? na-eji mannose agw? ?r?a urinary tract. N'af? nd? na-ad?begh? anya, n'?t?t? ihe nyocha nke na-egosi ?gw?gw? na mgbochi nke mannose, ?r? mannose na-agw? ?r?a ?r?a urinary ejiriwo nway?? nway?? d?ta uche nke ?gw? nd? b? isi.
Kedu ka mannose si ar? ?r??Mgbe a na-ewep? ya site na ak?r?, eriri afo, na urethra, mannose ga-ekpuchi mkp?r? nd? an? ah? na-agafe agafe na nje bacteria na-anwa ?rapara na sel ah?, na-eme ka nje bacteria ghara ?rapara na eriri afo na sel urinary duct, na-egbochi ?z? nje nje, na nje bacteria na-enwegh? ike ?rapagidesi ike na urinary tract ga-eso mmam?r? si n'ah?. ?t?t? ?r?a urinary na-ebute site na uropathogenic Escherichia coli (UPEC). UPEC na-ejik?ta mannose n'elu sel epithelial eriri afo site na protein FimH na mmam?r? ad?gh? ewep? ya ngwa ngwa. Ha gbanwere mannose iji nweta mannoside (M4284). Njik? ya na protein FimH d? elu 100,000 ugboro kar?a nke mannose, mana ? nagh? adabere na elu nke eriri afo ma nwee ike wep? ya na E. coli na mmam?r?.N'ime nnyocha mba ?wa nke 2016, nd? ?r?a na-ewere mannose maka ?b?ch? 13 nwetara mbelata d? ukwuu na mgbaàmà na mm?ba d? ukwuu na nd? ha d? ka a na-enyocha site na aj?j? ?n?. Iji gbochie ?r?a urinary na-emeghachi ugboro ugboro, nd? nch?p?ta ah? kewara nd? ?r?a ah? ?z? ab??, nd? ?r? ntinye aka n?gidere na-ewere mannose, nd? na-ach?kwa enwegh? ihe ? b?la. Nsonaaz? nke otu mannose, naan? 4.5% nke nl?ghachite n'ime ?nwa isii, ma e jiri ya t?nyere 33.3% nke otu njikwa. Nd? nch?p?ta ah? kwubiri na mannose nwere ike inye aka n'?gw? ?r?a ?r?a urinary nnukwu ma nwee ike igbochi nl?ghachi nke ?r?a urinary.