????, ?????? ?? ??????, ??? ???? ????? ???? ????? ??????? ?????? ?? ??? ????. ??? ???? ?????? ?????, ???? ???? ?? ??????? ???-??????, ??????-?????? ???-??????. ?????? ??? ???-???? ????? ????? ????, ???? ???? ?????? ?????? ???? ??? ???? ??????. ????? ??? ?? ?????????, ?????? ?? ?????? (???? 1).

???? ??? ???? ???? ?????? ???? ??????? ????. ???????? ?????, ??????? ??? ?-D-mannose ???? ????, ????, ???? ?? ????? ????? ?? ?????????? ???? - D-mannose.

?-1976, ???????? ????? ???? ?????? ??????? ?? ???????, ?? ???? ????? ?????? ???? ?????? ????? ??????, ???????, ?????? ?????? ??? ????? ????? ????????, ?????? ????????? ??? ?? ?? ????, ??? ?? ????, ????? ?????? ????? ???????.

???? 1:

????? ?-4-????-4-????????-2-?????? (??????? ???????) ????? ??????, ??? ????, ????? ????? ?? NaOBr ????? ?????? ????????, ????? ??? ????? ?????? ??????????...

???? ?????? ?-HMB Ca ??? ???? ?? ????? ???????, ???? ?? ???????, ?????? ?? ???? ????????? ????????????? ??????? ????? (LDL) ???? ??? ?????? ?? ???????? ?? ????? ?? ?????? ?????? ?? ???? ??.

?????? ?????? ?? ??????? ?????? E ??? ?????? E, ????? ???? ?? ?????? ???? ?????. ???????? ?????? E ?? ???? ??? ?? ??????? ????????? ?? ????? ??????, ????? ?????? ?????? ????????.

???????? ?????? ???????:

???? HMB ??? ??????? ????? ????? ?? ?????? ????? ??????? ???? ????, ??? ???? ????? ???? ??????? ????? ????? ?????, ???? ????? ??? ???? ?????? ????? ????.

????????? ?????? ?? ?????? ????????? ?????, ????????, ??????? ????? ??? ???????? ???????. ???????? ??? ????? ???? ????? ????? ??????? ?????? ???? ?????, ????, ???? ???? ????? ??? ????. ?????? ?????? ??? ??? C ? H ?? O ?, ????? ???????? ???? ????? ?????, ?? ?????? ?? ?-90% ??????, ????? ?-2.4 ??"? ?? ?????? ????. ????? ???, ???? (???? ??????) ??? ?? ???? ?????? ??????? ????????, ????? ?-4 ??"? ?? ?????? ????. ?????? ????? ????? ?????? ????? ????? ????? ???.

???? ???????, ??? ?????? ????? ?????? ????? ??????? ?????? E.

?????? E, ????? ?? ??? ?????? E ?? ????????, ??? ??? ???? ?????? ?????????? ????? ????? ???? ??????, ??????, ??? ??, ?????? ???? ?????.

??? ??????? ??????? E?

?????, ??????? ????? ??? ?????? C ???? ???? ??????? ????? ??? ???? ?-70. ??? ????? ??????? ??? "????? ?????? C ?????" ?"????? ????? ????? ?????? C", ???? ?????? ??????? ????? ?????, ?????? ?? ????? ?????????, ???? ????? ?? ?? ??.