??? ??????????? ??????? ??????, ????? ??????? ??????? ???? ??? ?????, ??? ?? ???? ?????? ??? ?????? ??????, ?????? ???????? ??? ?????? ???? ??? ?? ????? ??????? ???????? ?? ?????? ?????? ?? ???? ??. ??? ?? ????? ???? ?? ????, ?? ?????? ????? ?? ??? ?????? ?? ????? ?? ???? ?? ??????? ????.

?

????? ?? ???? ?? (CVD) ?? ???? ????? ?? ??? ??? ??????? ?? ????? ??????, ??????? ???? ???? ????? ??? ??? 50, ?? ?????? ?????, ????? ???? ???? ???????? ????? ??????. CVD ???? ????????? ???? ???, ????? ?????????, ????? ???? ?????? ???????????? ????? ????? ??????. ???, ?????? ????? ?????? ?? CVD ??? ????? ???? ????? ???? ??????? ??????? ?????.

?

??????? ????????, ?????? ???? ?????? ?? ?????? ??????? ?????? ?????? ?????? ?-CVD. ?????? ?????? ?? ????? ????? ?? ?????? ?????? ?? ????? ??? ?? ???????? ?????????, ???????? ????? ????? ???? ?????. ?????? ???? ?? ??????? ?????? ?? ????? ????? ???? ?-CVD ??????: ????? ????????, ????? ????? ???? ???, ????? ??? ?????? ?????? ??????, ????? ????????? ????? ?? ???? ??? ???? ??????? ?? ????? ???????/??????? (I/R).

?

?????? ?????? ???????? ?????? ????

?

???????? ??????

?

????????????? ??????? ??????? ?? ????????, ????? ????? ?????? ?????????, ??? ????? ??????? ?? ????? ?????? ???????? ??????. ????? ???????? ???? ?????? ?????? ?????? ???. ??? ?????? ?? rapamycin (mTOR), ????? ????? ????/??????, ??? ????? ???? ?? ?????????? ?????? ???????. ????? ?? mTOR ????? ????????, ???? ?-AMPK-activated protein kinase (AMPK) ???? ?????? ????? ?? ????????, ????? ?? ??? ????? ??????? mTOR.

?

???????? ??? ???????? ???? ????? ??????? ?????? ????, ???? ??????, ???????, ???????? ??????. ?? ?? ????? ??????? ????????? ???????????, ????? ?????? ???? ???????, ?????? ?????, ???? ????'??? ??????? ????? ?? ?? ???? ???????? ??????. ?????? ???? ?? ???????? ???? ???? ???????? ?? ??? ????? AMPK ??? ????? ???????. ?????, ???????? ???? ????? ???????? ???? ?? ??? ????? ????? ???????? mTOR complex 2(mTORC2).

?

??????? ???? ????????, ??? ????? ??????? ?? ???? ???? ???? ??? ?? ????? ?????? ????????, ???? ???? ???????, ?????? ????? ?????? ????????. ?????? AMPK, ?????? ???? ????? ???????? ?? ??? ????? AMPK ????? ?? ???? ???????? ?? ??? ????? mTOR.

?

???????? ??? ????? ?????? ?????? ??'???'? ????? ????? ?????? ?????. ???????? ???? ????? ???????? ?? ??? ????? ????? ?????? PI3K-AKT-mTOR, ????? ??? ?? ?????? ?????? ?? AKT ?-mTOR, ????? ???? ?? LC3-II, ????? ?????? ?? BECN1, ????? ??????????? ??? BECN1 ?- BCL-2, ?????? ????????? ?? FoxO1.

?

???? ??? ?????? ????? ??????

?

??? ?????? ????? ?????? ?? ???????? ??????????? ???????? ???????? ?????????????? ?? CVD. ???? ????? ????? ???? ??????? ?????? ???? ????? ?-CVD. ????? ????? ?? ???? ???? ????? ?? ???? ?? ??????? ???????? ?? CVD.

?

????? ??? ??????? ????? ???? ????? ????? ??????? ??????? ??? ?? ????? ???????? ????????, ???? ???????? ?????? ????? ????? ???????. Sesamine ???? ????? ?? ?????? ?? PPARγ, LXRα ?-ABCG1, ????? ?? ????? ????????? ??????????, ????? ??????? ??????? ???????? ?????? ?? ??? LDL ??????, ???? ????? ???????? ?? ??? ??? ??????????.

?

?????? ??? ????????? ?????? ?????? ????? ???? ???????????? ???????????? ?? ?????, ??? ?? ?????????? ?? ????????? ??????? ???? ???????? ?????. ?????? ????????????? ??????? ?? ?? ?????? ??????? ????? ???? ????? ???? ?????? ?-CVD. ?????? ????? ????? ?? ???? ?????? (ROS), ????? ????? ????????? ?? ????????? ???-??????? ????????????, ???? ????? ??? ???? ??? ?????? ?????????. ?????? ???? ???? ?????? ??????? ?? ??? ????? ????? NF-κB, ???? ???? ?? ?????? ?? ????? ??????? ?????????? ?? ??? ????? ????? ?????? Nrf2/ARE.

?

?'???'? ??? ??? ??-????? ????? ???? Zingiberaceae. ??'???'? ?????? ??????? ?????? ROS, ???? ?????????. ?? ???????? ??????? ??'???'?, ??? ????????, ?'???'??? ??'???'???, ???? ?????? ????? ?????. [6]- ?'???'??? ???? ?????? ?? ?????? ??????????? ???????? (SOD) ?? ??? ????? ????? ?????? PI3K/AKT ??????? ?? ????? ROS ?????? ??????????? ?????????????? ?? ????? ??????. ?????, ?????? ?'???'? ?????? ?-6-???????? ?????? ?????? ?????? ?????? ????? ?? ??? ????? Nrf2. ?? ????? ?? ?????? ????? ?? ??? ??? ?? ?'???'? ??????? ??????? ????? ????????, ???? ????? ??? ?????? ?????, ????? ?????? ?????? ????? (NO), ????? ????? ??? ???? ??? ???? ??? ?????? ????????.

?

????? ?? ????? ???? ???

?

??????? ?????? ???????? ????? ??????? ???, ???? ????? ??????? ????? ?? ???? ???, ?? ?????? ?????? ?? CVD. ????? ????? ???? ??? ??????? ???????? ??????????? ??????????? ???????? ??????????? ?? ?????????????, ???????? ????? ???? ???, ???????? ????? ?? ??? ??????? ?????? ?? ???? ???, ????? ?????? ??? ?????? ?? ??? ?? ????? ??. ?????????? II ????? ?????????? ?? ????????????? ?????? ????? ??????????? ?????? ????? ?????? ???-???. AMPK ???? ????? ???? ???????? ?? CVD, ????? AMPK ????? ?????????? ?? ??? ????? ?? ??? ????? ???? ??? ????? ??.

?

???? ?????? β1 (TGF-β1) ?????? ????????? ???? ????? ????? ?????? ??????????? ?????? ??????? ???????????? ??????. FoxO1 ??? ???? ????? ?????? ??????????, ??? ??????? ????????? ????. TGF-β1 ????? ?? ????? FoxO1, ????????????? ??????, TGF-β1 ????? ?? ????? FoxO1, ????? ????????? ??????? ?? FoxO1, ????? ?? ???? ?????? FoxO1 ????? ???????? ?? ??????????? ?????? ???????????? ??????.

?

Baicalin ??? ?????? ????? ?????? ???????? ?????? ?? scutellaria baicalensis. Baicalin ???? ???????? ???? ?????? ?? ??? ???? ??? ?? ??? ????? ?????? ????? AMPK/TGF-β/Smads. ??????? ???????? ?? baicalin ?????? ????? ?? ???????? ???? in vivo ?-in vitro ?? ??? ????? ????? ?????? AMPK/TGF-β/Smads. Baicalin ?? ???? ?? Smad3 ??? ??????????? ???????? ?? Smad3 ?? ???? ????? ???? p300, ???? ???? ??????? ?? ???????? ???? ?????? ?????????? II.

?

Epicatechin ??? ????????? ????-?????? ?????? ??? ???? ???? ???? ????? ?? ?????. Epicatechin ????? ?????????? II ??????????? ????? ?????? ???? ???. Epicatechin ???? ?? ?????? ?? ?????? c-Fos ?-c-Jun ??????? ?? ??? ?????????? II, ???? ???? ?? ?????? AP-1. ?????, epicatechin ???? ???? ?? ?????? NF-κB ?? ??? ????? ?????? ????? ????? ROS p38 ?-JNK, ??????? ?? ????? AP-1 ??? ????? ?? ????? ?? epicatechin ??????? ?? ?????????? ????? ?? ??? ????? ???????????? ?? EGFR ???????? ????? ???? ??? ERK/PI3K/00/mTOR inhibition ?? natrial/mTOR ????? ?? ???. ????? ????? ???? B ????? ???? ?? ??????? ????? ???? ?????? ??????? ?????????? ?????. Epicatechin ?? ???? ????? ROS ?????? ?? ??? ?????????? II ?????? NADPH ????????, ???? ???? ?????????? ????? ?????? ??.

?

????? ?? ????? ?? ????????? ?? ?????? ?????? ?????? ?????? ?????? ?? ???? ??. ??? ??????????? ??????? ??????, ????? ?? ???? ?? ??????? ???????? ?????? ????? ?????? ?? ?????? ??????. ?????? ?????? ?????? ?????? ???? ?????? ?????? ?????? ????? ??? ??????? ????????? ???????? ??????.

?

?????? ???? ?? ?????? ?????? ?????? ???? ????????, ??????, ????????, ??????, ?'???'?, ????????, ????????, ????? ?????, ????????, ?????, ??????? IIA ????????? E ?? ??????? ????? ?????? ?????? ????????, ????? ??? ?????? ????? ????? ?????? ??????, ?????? ????? ???????/??????? ?????. ?????? ?????? ??? ?????? ????? ???? ?? ??? ???? ??? ?? ??? ????? ?? ????? ?????? ?????, ???? mTOR, AMPK, NF-kB, Nrf2 ???'.

?

?????, ????? ????? ??????, ??? ????? ????? ????? ??????, ????? ????? ?? ?? ???? ????, ?????? ????? ?????? ?????? ?????? ?? ???? ??. ?????? ????????????? ?????? ???????? ??????? ?????? ???? ??. ??????, ??????? ?????? ??? ???'???? ??? ????, ?????? ???????? ??'???'??? ??'???'? ???? ?????? ???? ????????? ?? ??? ???? ???.

?

?? ???, ????? ???????? ?????? ?? ????? ????? ????? ?? ????? ????? ?? ???? ??, ?? ????? ??? ?????? ???????. ??????, ??????? ????????? ?? ??? ???????? ??????? ?????, ?????? ?????? ???? ???? ??????, ??? ???? ??? ???? ?? ??????? ???????. ?????, ????? ??????????? ??? ?????? ?????? ?????, ??? ???????????? ?? ?????? ???? ?????? ????? ???? ????.