1.1 ?????? ???? ??? ??? ??????? ??? ??? ???????

???? ?????????? ????? ??????? ?? ??? ???? Takeda Pharmaceuticals ???? ???? 1956, ???? ??????? ?????????? ?????? ?? ??? ???????? ?? ????? ?????????:

• ???? ?-80:???? ?? ????? ?????? ???? ??? ???? ??? ????

• ???? ?-2010:???? ?? ??? ???? ?????? ?? ????? ??? ???? (PET-CT ???? ????? ?? 23% ?????? ??? ????? ????)

• ???? 2024,?-NIH ?? ????? ????? ??? ???? ????? ???????? ????? ?"????? ????????????"

1.2 ????? ????? ?? ???? ??????

??? ????? Evaluate Pharma:

??????? ????????? ????? ?-4.7 ??????? ???? ???? 2024 (CAGR 12.3%)

?????? ??????? ???? ????? ?????? ???? ??? ?-400% ????? ????

??????????? ?????? ?:

?????? ???????? (???? MMSE ????? ?-2.1 ??????)

????? ????? ???????? (???? ?????????? ?? GOS ??? ?-1.5 ?????)

??? ???: ????? ????? ????? ?? ?????? ??????

?

2.1 ?????? ????? ???????

??? ????? ????? ?????: ?????? ?????????????? ????? ?? ????? ??????? ??????. ????? I: ????? ?????????? ?????? ?? ????? ????????????????. ????? IIA: ????? ?????? ?????? ????? ???? ?? ????? ??????-????????? (????? ?? 18% ?????). ????? IIB.

?

2.2 ????? ???? ???? ??????

???? ???? 2024 ?? ??? ?????? ?????? ?????? ?? ?????????? ??? ???-?? ????:

????? ??? ?????? ?? 1000 ?"? ??? 6 ???? ???? ???? ???? ????? ????? ?? 7.2 ?"? ??? ?? ??????? ???????.3

?? ???, ?? ???? ???? ????? ???????? ???? ??? ?????? ??? ?? 72 ???? (p=0.34).

??? ?????: ??????? ???????

?

3.1 ????? ???? ????

?????? NICE ????????: ?????? ??? ??????? ??????? ???? ??????? ??? ????? ?????? ?????? ?????? (??? ????-????? 45,000 ???"?/QALY)

Lancet Neurology **???-?????? 2025: ??? ???? ??????? ?????? ?????? ?????? ?????????? ??? (p=0.21)

3.2 ???? ?????? ?????

????? ?????? ?????? ??????? ??????? ???? 2024:

???? ??? ????? ?????? ??????????? (????? "????? ???'?????" ?"????? ??????")

?????? ????????? ???? ???????? ?????? ????? ?? ?????? ????? ?? 32% ????????? ?????? ??? ??? ??? ???? ?-70% ?????? ???????.

??? ?????: ?????? ?????? ???? ???????????

?

4.1 ????? ???? ?????? ??????

????????? ????? ????? ????? ???? ????? ??-??? (???? ?? ???? ?????????? ?????, CN202410123456.7)

?????-????? ????? ????? ????? ????? ????? (??????? ????? ???? ??????????? ??????? ?? ????? ????? ?????? ????? ????? ?? ????? ??????? ?????????)

?

4.2 ??? ?????? ??????? ?????? ?????

????? ?????? ?? Bgi ??? ??:

????? ??????? ?? ????????? ??????????? ?? ?? CDP-????? ?????? (?????? 31% ?????????? ????) ???? ?-47%

??? ??? - ?????? ??????? ?? ???????

?

5.1 ???? ??????

????? ???? ????? ??????? ??????'???: ???? ????? ?????, ?????? ????? ??? ?????? ??????? ?? ????? ?? 62 ?? ???? ???? ??????? ?-32% ?-89%.

5.2 ????? ????? ?? ??? ?????

"???? ????? ?????? ???? ??? ??? ???????, ?????? ??????? ?? 300 ???? ???? ?? ??? ????? ????" - ????? ????? ?? ??' ??, ?????? ?????'???.